Phagocytic Clearance And Immune Activation In Malaria
Funder
National Health and Medical Research Council
Funding Amount
$564,644.00
Summary
Macrophage white blood cells clear malaria infected cells by eating them, by three routes- by recognising ANTIBODIES or COMPLEMENT on the cell surface, or by the cell BINDING directly to the macrophage. Each has different results, such as amounts of cytokines produced. Cytokines clear malaria; in excess they can cause fatal immune pathology. We will investigate how variations in amount of antibody and complement and route of uptake of malaria infected cells might determine malaria outcome.
A specialised set of T lymphocytes called Mucosal Associated Invariant T (MAIT) cells react against bacteria and yeast, and reside at mucosal sites where the body's immune defences are most easily breached, e.g. respiratory tract and intestinal mucosa. This study investigates the role of MAIT cells in both protection and pathology in bacterial infections. Controlling MAIT cells could help in treating these conditions.
A Novel Lipid Sensitive Kinase And Its Role In Obesity-induced Inflammation And Insulin Resistance.
Funder
National Health and Medical Research Council
Funding Amount
$560,045.00
Summary
It is now apparent that obesity leads to chronic low grade inflammation which results in insulin resistance or pre-diabetes. The mechanisms that link obesity-induced inflammation to insulin resistance are not well understood, but involve lipid oversupply. We have preliminary data identifying that a protein, not known to previously play a role in metabolic diseases, is a critical mediator of lipid-induced inflammation. We will investigate the clinical potential of blocking this protein.
Targeting Adenosine Mediated Immunosuppression To Enhance CAR T Cell Activity
Funder
National Health and Medical Research Council
Funding Amount
$633,447.00
Summary
The use of white blood cells genetically engineered to eradicate cancer cells specifically has been a major breakthrough in cancer treatment. These cells (CAR T cells) are very effective in blood cancers, but do not currently work well in other cancers. This is due to the immune suppressing nature of the cancer environment. I propose to use strategies to overcome this by genetically reprogramming the CAR T cells to be resistant to suppression by the cancer and therefore be more effective.
The Mezzanine T Cell Response: Intervening At The Coal Face
Funder
National Health and Medical Research Council
Funding Amount
$765,585.00
Summary
In an initial immune response, specialised cells in lymph nodes tell T cells to multiply; the stimulated T cells depart and enter target tissue (e.g. lung in the case of flu). We describe a new response whereby the target tissue itself can tell T cells to multiply further. This response in target tissues reveals a new way of altering immune responses. This is especially important as in many diseases, the primary lymph node response has already occurred, so cannot be therapeutically intervened.
Why is (re)development hot?: Measuring cumulative heat in Australian cities. Incremental (re)development of Australia’s residential areas occurs piecemeal, with varied planning oversight, and results in potentially harmful cumulative warming. This project aims to causally identify the warming effect of residential (re)development and investigate the impact of planning policies that control changes in the built form associated with increased heat exposure. Using large geospatial datasets and a qu ....Why is (re)development hot?: Measuring cumulative heat in Australian cities. Incremental (re)development of Australia’s residential areas occurs piecemeal, with varied planning oversight, and results in potentially harmful cumulative warming. This project aims to causally identify the warming effect of residential (re)development and investigate the impact of planning policies that control changes in the built form associated with increased heat exposure. Using large geospatial datasets and a quasi-experimental research design, warming in Australia’s suburbs over the past decade at the micro (street canyon)- and neighbourhood-scales, will be attributed to (re)development types and ‘fissures’ in policy to inform climate resilient planning. Read moreRead less
Tropical convection and its contribution to climate variability. This research will provide the necessary data to test and improve the representation of tropical convective clouds in weather forecast and climate simulation models. This will lead to more robust estimates of future climate change, and improved prediction of precipitation in the Australian tropics. This project will also provide training to undergraduate and postgraduate students in using modern computer models; such models will be ....Tropical convection and its contribution to climate variability. This research will provide the necessary data to test and improve the representation of tropical convective clouds in weather forecast and climate simulation models. This will lead to more robust estimates of future climate change, and improved prediction of precipitation in the Australian tropics. This project will also provide training to undergraduate and postgraduate students in using modern computer models; such models will be a key component of weather forecasting in the future.Read moreRead less
Rainfall over the Maritime Continent and Northern Australia. Australia's proximity to the tropics results in major influences, both direct and indirect, of tropical weather and climate on society as a whole. Tropical convection is key to all those influences. The prediction of the many natural hazards related to convection as well as a projection of the influence and strength of these hazards under climate change is a matter of high national priority. Through an improved understanding of convect ....Rainfall over the Maritime Continent and Northern Australia. Australia's proximity to the tropics results in major influences, both direct and indirect, of tropical weather and climate on society as a whole. Tropical convection is key to all those influences. The prediction of the many natural hazards related to convection as well as a projection of the influence and strength of these hazards under climate change is a matter of high national priority. Through an improved understanding of convection over tropical Australia and in its vicinity, the proposed research will improve our predictive tools and capabilities, thereby making a major contribution to decision-making in an environmentally sustainable Australia.Read moreRead less
Understanding and modelling of interannual hydroclimatic variability in the context of historic streamflow. Recent persistently dry conditions in Australia have triggered water restrictions in major cities and re-emphasised the importance of water to this country. This project represents an integrated package of research that will enhance our understanding of interannual hydroclimatic variability, and its implications for land and water resources systems. The methodologies and model developed he ....Understanding and modelling of interannual hydroclimatic variability in the context of historic streamflow. Recent persistently dry conditions in Australia have triggered water restrictions in major cities and re-emphasised the importance of water to this country. This project represents an integrated package of research that will enhance our understanding of interannual hydroclimatic variability, and its implications for land and water resources systems. The methodologies and model developed here will directly lead to more informed decision making for sustainable use and management of Australia's increasingly scarce natural resources to cope with changing climate over a range of time scales. This is particularly important for Australia because of its higher interannual hydroclimate variability compared to elsewhere in the world.Read moreRead less
Climate Change And Human Health In Asia: Current Impacts, Future Risks, And Health Benefits Of Mitigation Policies
Funder
National Health and Medical Research Council
Funding Amount
$655,308.00
Summary
This project will comprehensively examine the burden of diseases attributed to ambient temperature in the context of climate change in Asia Pacific region, where has 60% of the world's population and nearly two-thirds of the world's poor. Knowledge arising from the project will provide vital evidence for governmental policy on implementation of the mitigation and adaptation policies to address the health challenges associated with climate change.