Investigating The Link Between Oxidative Stress And Biomechanical Integrin Activation In Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$653,742.00
Summary
Diabetes represents a serious healthcare problem globally. A large proportion of deaths associated with diabetes can be attributed to the development of blood clots in the circulation of the heart and brain (heart attack/stroke). The blood clotting mechanism is ‘hyperactive’ in diabetes, although the reason for this is not well defined. In this proposal we will investigate a new mechanism promoting blood clots, and will investigate innovative approaches to reduce this clotting mechanism.
Optimal Source Control in Urban Water Cycle Management. Major opportunities exist to improve the management of the urban water cycle by better use of source control technology such as the use of rainwater tanks and water-sensitive design. This program will optimise the use of this technology at three scales, allotment, subdivision and regional, using genetic algorithms, parallel computing and shadow pricing. The aim is to minimise community lifecycle costs subject to sustainable use of ecosystem ....Optimal Source Control in Urban Water Cycle Management. Major opportunities exist to improve the management of the urban water cycle by better use of source control technology such as the use of rainwater tanks and water-sensitive design. This program will optimise the use of this technology at three scales, allotment, subdivision and regional, using genetic algorithms, parallel computing and shadow pricing. The aim is to minimise community lifecycle costs subject to sustainable use of ecosystems and maintenance of public health standards. The benefits include national savings of the order of $2 billion and significantly reduced demand on water supply and stormwater infrastructure and its supporting ecosystems.Read moreRead less
Modelling long-term hydrological persistence using hidden state Markov models. Long-term climatic persistence has a pronounced effect on engineering risk assessment of drought and flood severity. Accurate risk assessment is essential for economic design of water resource and flood defence infrastructure. A new, physically realistic, framework for stochastic modelling of persistence is developed, in which the probability distributions of hydrological variables depend on underlying climatic states ....Modelling long-term hydrological persistence using hidden state Markov models. Long-term climatic persistence has a pronounced effect on engineering risk assessment of drought and flood severity. Accurate risk assessment is essential for economic design of water resource and flood defence infrastructure. A new, physically realistic, framework for stochastic modelling of persistence is developed, in which the probability distributions of hydrological variables depend on underlying climatic states. These states are not directly observable, and occasionally change in a random manner. The research program, involving three PhD projects, will develop: estimation techniques and software using climate indices and multi-site data; a new approach to flood risk regionalisation; and seasonal rainfall forecasting methods.Read moreRead less
Australasian climate reconstruction for the past two millennia. The results generated during this Fellowship will provide a greater understanding of the sensitivity of the Australasian region to the natural range of climatic variability (far beyond that recorded by historical datasets). Focussing on the past two millennia, the applicant will help investigate the timing, rate and magnitude of change, allowing a robust test of whether past changes were in phase with the Northern Hemisphere. The ....Australasian climate reconstruction for the past two millennia. The results generated during this Fellowship will provide a greater understanding of the sensitivity of the Australasian region to the natural range of climatic variability (far beyond that recorded by historical datasets). Focussing on the past two millennia, the applicant will help investigate the timing, rate and magnitude of change, allowing a robust test of whether past changes were in phase with the Northern Hemisphere. The results will provide a considerably improved context for understanding present and future climate change in the Australasian region. Read moreRead less
Alcoholic Chronic Pancreatitis: Induction, Progression And Reversal
Funder
National Health and Medical Research Council
Funding Amount
$632,211.00
Summary
Pancreatitis (inflammation of the pancreas) is a serious complication of alcohol abuse. Patients suffer from severe and often intractable abdominal pain, maldigestion and diabetes, We have recently shown that gut toxins (endotoxins) may act as a trigger factor for pancreatitis in alcoholics. The proposed project aims to characterise the effects of gut toxins on the pancreas during alcohol abuse so as to identify pathways that may be therapeutically targeted to prevent or retard the disease.
Discovery Early Career Researcher Award - Grant ID: DE130100663
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Understanding the termination of El Nino-Southern Oscillation events. Australia's climate is extreme, with significant drought and flooding events driven by cycles of the El Nino-Southern Oscillation (ENSO). This study will improve our understanding of the termination of ENSO events and lead to better inter-seasonal climate forecasting, aiding the sectors reliant on accurate climate prediction.
Remote forcing of Pacific Ocean variability and impacts on global climate. Variability in the Pacific Ocean has a profound impact on global climate. Recent unprecedented decadal variability in the Pacific has been linked to global temperature trends and extremes, yet little is known about what drives this variability or its impact on regional climate. This project will combine observations, advanced coupled climate models and ocean-atmosphere dynamical theory to quantify remote drivers of Pacifi ....Remote forcing of Pacific Ocean variability and impacts on global climate. Variability in the Pacific Ocean has a profound impact on global climate. Recent unprecedented decadal variability in the Pacific has been linked to global temperature trends and extremes, yet little is known about what drives this variability or its impact on regional climate. This project will combine observations, advanced coupled climate models and ocean-atmosphere dynamical theory to quantify remote drivers of Pacific Ocean variability on interannual-decadal time-scales. This project aims to enhance our understanding of the modes of variability operating in this region and their impact on global and Australian climate. This will have significant benefits for the many sectors of society reliant on interseasonal-decadal climate prediction.Read moreRead less
Abrupt Southern Hemisphere Climate Change: The Role Of The Southern Ocean Thermohaline Circulation. Australia's climate is extreme, with harsh droughts, severe bushfire seasons, climate change, soil loss, and salinity all posing potentially enormous socio-economic challenges over the next ten-fifty years. Research into climate change and climate variability is thus highly significant for Australia, and will underpin efforts to protect our biodiversity and ensure the nation's environmental sustai ....Abrupt Southern Hemisphere Climate Change: The Role Of The Southern Ocean Thermohaline Circulation. Australia's climate is extreme, with harsh droughts, severe bushfire seasons, climate change, soil loss, and salinity all posing potentially enormous socio-economic challenges over the next ten-fifty years. Research into climate change and climate variability is thus highly significant for Australia, and will underpin efforts to protect our biodiversity and ensure the nation's environmental sustainability. We propose to launch a major new study of the stability of the Southern Ocean's thermohaline circulation and its role in global climate. This work could have significant long-term benefits for those sectors of society sensitive to shifts in climate; including agriculture, energy, freshwater supply, health, and tourism.Read moreRead less
Coupled ocean-carbon-atmosphere feedbacks in the global climate system. The capacity of the oceans to absorb and store carbon fundamentally regulates atmospheric CO2 concentrations. Climate change is altering the flux of carbon between the ocean and atmosphere, and may reduce the capacity of the oceans to store carbon. Research into climate change and the global ocean carbon cycle is of high national significance, and will underpin efforts to protect our biodiversity and ensure Australia's env ....Coupled ocean-carbon-atmosphere feedbacks in the global climate system. The capacity of the oceans to absorb and store carbon fundamentally regulates atmospheric CO2 concentrations. Climate change is altering the flux of carbon between the ocean and atmosphere, and may reduce the capacity of the oceans to store carbon. Research into climate change and the global ocean carbon cycle is of high national significance, and will underpin efforts to protect our biodiversity and ensure Australia's environmental sustainability. We propose a major new study of the nature of coupled ocean-carbon-atmosphere feedbacks operating in the global climate system. This work will quantify how the ocean's carbon storage capacity might shift in the future, guiding policy-makers in setting future CO2 emissions targets.Read moreRead less
Modes of Pacific Ocean variability and their relationship to regional Southern Hemisphere climate. This project will provide a thorough examination of the role of the major Pacific Ocean modes in forcing variability in Australian climate. Enhancing our knowledge of the mechanisms driving natural modes of variability and how they affect Australian rainfall is fundamental for improving seasonal forecasting and long-term climate prediction. Results from this research can contribute to the underpinn ....Modes of Pacific Ocean variability and their relationship to regional Southern Hemisphere climate. This project will provide a thorough examination of the role of the major Pacific Ocean modes in forcing variability in Australian climate. Enhancing our knowledge of the mechanisms driving natural modes of variability and how they affect Australian rainfall is fundamental for improving seasonal forecasting and long-term climate prediction. Results from this research can contribute to the underpinning sciences that inform on the risks associated with climate extremes and climate change. This is extremely beneficial to Australia, as it can have implications for adaptation strategies, assisting the socio-economic sectors dependant on climate forecasting, including agriculture, natural resources, bushfire control and water management.Read moreRead less