Delineating The Clinical And Molecular Heterogeneity Of Fatty Liver Disease To Inform Treatment
Funder
National Health and Medical Research Council
Funding Amount
$1,731,372.00
Summary
Fatty liver disease from excess weight affects 1 in 3 adult Australians. The disease has no treatments and many patients develop liver failure or liver cancer. Clinically, the disease is characterized by marked heterogeneity, a challenge for developing biomarkers and treatments. To move towards precision medicine, this project will undertake an inter-disciplinary program that embraces disease complexity and integrates environmental and genetic risk with the power of mathematical modelling.
Development Of Novel Therapies To Treat Obesity Related Metabolic Diseases
Funder
National Health and Medical Research Council
Funding Amount
$2,981,372.00
Summary
Obesity results in the development of many diseases particularly as we age. These diseases include type 2 diabetes, fatty liver diasease and dementia. This research rpogram with develop new strategies and therapies targeted to treat these obesity related diseases.
Developing Novel Therapeutic Approaches To Treat Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,173,545.00
Summary
Progression of chronic kidney disease (CKD) to endstage is characterised by inflammation and fibrosis. No current treatment effectively halts CKD progression. We are using protective immune cells to treat CKD and have invented a genetically-engineered immune cell which uses damaging inflammatory signals to switch them into protective cells which reverse inflammation and fibrosis where they occur, to prevent progression of CKD and other diseases, such as those of heart, lung and liver.
Driving Change To Improve Aboriginal And Torres Strait Islander Kidney Health
Funder
National Health and Medical Research Council
Funding Amount
$1,050,000.00
Summary
The burden of kidney disease affecting Aboriginal and Torres Strait Islander communities is devastating. Community members prioritise prevention of kidney disease, early detection and treatment to stop progression to dialysis. In remote areas, people requiring dialysis have to move away from their family and supports. This work will focus on innovative ways to address this disparity to improve care, treatment and services for Indigenous people living with kidney disease.