Development Of Endpoints For Catheter Ablation Of Non-mappable Scar-related Ventricular Tachycardia.
Funder
National Health and Medical Research Council
Funding Amount
$176,686.00
Summary
Ventricular tachycardia is a dangerous heart rhythm disturbance that affects people with scarring in the heart such as those with prior heart attacks or heart failure. Catheter ablation procedures, using wires passed from the groin, can be used to burn the short-circuits related to the scar. However in the majority of cases, it is very difficult to know when enough burning has been performed. This project aims to develop and validate several electrical and imaging endpoints for this procedure.
Obesity, Insulin Resistance And Hepatocarcinogenesis: Metabolic Mediators And Molecular Mechanisms
Funder
National Health and Medical Research Council
Funding Amount
$199,485.00
Summary
Liver cancer (or hepatocellular carcinoma, HCC) is the 3rd most common cause of cancer death, with the incidence in Australia increasing. Recently, it has been shown that obesity, diabetes and fatty liver disease can lead to HCC; this project will explore how metabolic diseases promote HCC. The role of insulin and fatty acids in promoting DNA damage and cell growth will be examined. Understanding how metabolic disease increases HCC risk will improve prevention strategies and possible treatments.
Efficacious Targeting Of Therapeutic Stem Cells To Diseased Livers
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
This project focuses on the challenging area of effective and optimal dosing of stem cell-based therapy for liver diseases. I will investigate the fate and therapeutic effects of natural, surface-modified stem cells and cell-derived vesicles in the body and in liver regions using mathematical models. My key goal is advance cell therapy by providing better dosing and cell engineering strategies.