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Protective Mechanisms Of MAP Kinase Phosphatase 5 In Adipose Tissue Fibrosis, Hepatic Steatosis And Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$352,729.00
Summary
Obesity and associated complications such as diabetes, non-alcoholic fatty liver disease and atherosclerosis are a serious health burden. Recently, we found that MKP5, a molecule that restricts intracellular signaling, plays a central role in preventing these diseases. This collaborative project will elucidate how precisely MKP5 acts and explore how this molecule can be targeted for the development of novel therapeutic strategies in prevention and treatment of human metabolic diseases.
Impact Of Exercise Intervention On The Phenome (Metabolism And Predictive Complications) In Well Characterised Prediabetes And New Onset Type 2 Diabetes Cohorts In China And Australia (TheDiabeEx.JointStudy).
Funder
National Health and Medical Research Council
Funding Amount
$567,323.00
Summary
This proposal will study people with prediabetes or a new diagnosis of type 2 diabetes, compared with a group with normal blood glucose, in China and in Australia. It will examine, in well defined cohorts: 1. the extent of traditional and more novel organ complications and metabolic markers early in the disease course; 2. in people with abnormal blood glucose, the potential benefits of an exercise regimen to their metabolic health, biomarkers and complications.
Role Of Sphingolipid Signalling In Hepatic Insulin Resistance And Its Application In Prediction Of Risk For Type 2 Diabetes And Prediabetes
Funder
National Health and Medical Research Council
Funding Amount
$563,305.00
Summary
Type 2 diabetes is expected to reach epidemic proportions in the coming decades. Prediabetes is usually unrecognized and constitutes a major public health concern that needs earlier interventions, because the majority of prediabetic subjects proceed to T2D. We have identified an enzyme that plays an important role in insulin signalling. The possibility is that the level or activity of this enzyme is a potential biomarker of the prediabetes state and could be also used as a target
Breast Cancer Risk After Diagnostic Gene Sequencing (BRIDGES)
Funder
National Health and Medical Research Council
Funding Amount
$471,281.00
Summary
In BRIDGES, we aim to build a knowledge base to better define individual breast cancer risk. We bring together, in a multidisciplinary team, data and expertise from clinical genetics, epidemiology, bioinformatics, statistics, and gene biology. Specifically, we will use state-of-the art DNA screening to evaluate all suspected breast cancer genes in a large sample of breast cancer cases and controls. We will then use in silico and in vitro functional analyses to evaluate the likely pathogenicity o
Breast CAncer STratification: Understanding The Determinants Of Risk And Prognosis Of Molecular Subtypes
Funder
National Health and Medical Research Council
Funding Amount
$472,984.00
Summary
Breast cancer is not one disease, but many different types with different causes, treatments and outcomes. The aim of this project is to use genetic, lifestyle/environmental, mammographic breast density, pathologic and clinical data froma very large number of studies from all over the world to develop ways of predicting which women are at risk of particuar types of breast cancer, and if breast cancer develops what the likely outcome will be.
Early Detection Of Lung Cancer And Mesothelioma In Asbestos Workers At Highest Risk
Funder
National Health and Medical Research Council
Funding Amount
$623,268.00
Summary
Through no fault of their own, many Australian workers have been inadvertently exposed to asbestos and are at high risk of developing lung cancer and mesothelioma. With the peak incidence bearing upon us, there is an urgent need for early detection by CT.
Application Of Omics-based Strategies For Improved Diagnosis And Treatment Of Endocrine Hypertension
Funder
National Health and Medical Research Council
Funding Amount
$461,322.00
Summary
Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. We will define specific omics profiles for patients with a range of hypertension-related disorders by integrating high throughput genetics, genomics and metabolomics data. This should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.
Nutrition And Rehabilitation In Advanced Cancer Patients
Funder
National Health and Medical Research Council
Funding Amount
$225,991.00
Summary
This preliminary project aims to evaluate associations between cancer cachexia, psychosocial factors and cytokine levels in blood. The final decline of most patients with advanced cancer is associated with the cancer cachexia syndrome, triggered in part by cytokine release. Measuring cytokines may enable identification of patients about to enter this final stage. Further, factors like mood and social support appear to alter cytokine levels. The associations established by this study may point to ....This preliminary project aims to evaluate associations between cancer cachexia, psychosocial factors and cytokine levels in blood. The final decline of most patients with advanced cancer is associated with the cancer cachexia syndrome, triggered in part by cytokine release. Measuring cytokines may enable identification of patients about to enter this final stage. Further, factors like mood and social support appear to alter cytokine levels. The associations established by this study may point to treatment options that can delay the terminal phase while improving quality of life.Read moreRead less
Patterns Of Cancer Care For Indigenous People In NSW
Funder
National Health and Medical Research Council
Funding Amount
$1,690,636.00
Summary
Cancer is the second biggest killer of Indigenous Australians: for some cancers the mortality rate is more than 3 times higher in Aboriginal people and overall it is 60% higher. While differences in stage at diagnosis and the type and duration of care received by Aboriginal people may contribute to the higher mortality, this has not been studied in detail. New South Wales has the largest Aboriginal population in Australia. Reliable and current data on cancer care for NSW Aboriginal people will a ....Cancer is the second biggest killer of Indigenous Australians: for some cancers the mortality rate is more than 3 times higher in Aboriginal people and overall it is 60% higher. While differences in stage at diagnosis and the type and duration of care received by Aboriginal people may contribute to the higher mortality, this has not been studied in detail. New South Wales has the largest Aboriginal population in Australia. Reliable and current data on cancer care for NSW Aboriginal people will allow health services to better target cancer care. The aims of this project are: to determine whether Aboriginal people are being diagnosed with cancer at later stages; to describe the barriers to Aboriginal people being diagnosed earlier and accessing cancer care; to describe the care that Aboriginal people with cancer are currently receiving; and to compare their level and types of care with that received by non-Indigenous people. We will conduct four studies to address these aims. We will conduct interviews with Aboriginal people diagnosed with cancer and Aboriginal health workers who look after people with cancer to find out about their perceptions and experiences of Aboriginal people dealing with cancer. We will analyse a data set containing records from the NSW Central Cancer Registry and hospital admission records for people living in NSW. Treatments for cancer for Aboriginal and non-Indigenous people will be compared. This analysis will be complemented by an examination of records at Aboriginal Medical Services to obtain information on other treatments such as chemotherapy and radiotherapy and referrals to specialists. We will also conduct a population-based patterns of care study where questionnaires seeking information about the diagnostic tests performed and types of treatment given will be sent to doctors who have treated Aboriginal people with cancer. In addition, information will be obtained from Aboriginal people with newly diagnosed cancer about the clinical pathway that led to the diagnosis.Read moreRead less