Obesity And Protective Properties Of High-Density Lipoproteins
Funder
National Health and Medical Research Council
Funding Amount
$391,265.00
Summary
High-density lipoproteins (HDL) are the good form of cholesterol and protect against heart disease. Obesity is associated with a high risk of heart disease and low HDL levels. The effects of obesity on the ability of HDL to prevent plaque build up in the artery wall has not been studied. This project will study how obesity affects the ability of HDL to stop plaque formation. This will provide important information linking two major health problems in Australia, obesity and heart disease.
Atherosclerosis - The Key Roles Of HDL, Cell Cholesterol Metabolism And Vascular Function
Funder
National Health and Medical Research Council
Funding Amount
$7,085,050.00
Summary
Atherosclerosis, an accumulation of cholesterol in the artery wall, is a major cause of illness and premature death worldwide. It is caused by conditions such as low levels of the protective high density lipoproteins (HDLs), diabetes, smoking and abnormal function of arteries, all of which are linked to disorders of cholesterol metabolism. With our expertise in HDLs, cholesterol metabolism and artery function, our research will lead to the development of novel strategies for early detection and ....Atherosclerosis, an accumulation of cholesterol in the artery wall, is a major cause of illness and premature death worldwide. It is caused by conditions such as low levels of the protective high density lipoproteins (HDLs), diabetes, smoking and abnormal function of arteries, all of which are linked to disorders of cholesterol metabolism. With our expertise in HDLs, cholesterol metabolism and artery function, our research will lead to the development of novel strategies for early detection and prevention of atherosclerosis and heart disease.Read moreRead less
Biochemistry And Functional Significance Of Glycosylation Of Apolipoprotein E
Funder
National Health and Medical Research Council
Funding Amount
$485,000.00
Summary
Apolipoprotein E (apoE) is an important molecule which affects our risk of atherosclerosis- coronary disease and of Alzheimer's disease. We know that apoE's functions are very much affected by its structure. One aspect of tis structure which has been neglected is the attachment of sugar molecules . These are very likely to regulate how apoE interacts with other molecules, with cells, and is metabolised in the body and will be investigated in this project.
Multifunctional Regualtion Of Angiogenesis By High Density Lipoproteins
Funder
National Health and Medical Research Council
Funding Amount
$480,653.00
Summary
For many sufferers of heart disease and cancer, current treatments do not relieve the debilitating symptoms. The growth of new blood vessels can alleviate the effects of a restricted blood supply, caused by blocked arteries. Conversely, new vessel growth accelerates some diseases such as cancer. HDL is one of the main forms of cholesterol in the blood. Recently we identified a beneficial bifunctional role for HDL in vessel growth. This project will investigate the mechanisms for these effects.
Plasma Metabolomic Profiling Of Patients With Serial Coronary Atheroma Progression For Predicting Myocardial Infarction And Death
Funder
National Health and Medical Research Council
Funding Amount
$373,114.00
Summary
Heart attacks are the leading cause of death, and half of all 1st heart attack victims have </= 1 known risk factors for coronary heart disease. There is an urgent need to better predict heart attack risk, and to develop new drugs to combat atherosclerosis. This study will involve a more advanced technique of identifying new molecules found in people who demonstrate progression of coronary atherosclerosis, heart attack and death, in the setting of a large-scale clinical trial testing a new ag ....Heart attacks are the leading cause of death, and half of all 1st heart attack victims have </= 1 known risk factors for coronary heart disease. There is an urgent need to better predict heart attack risk, and to develop new drugs to combat atherosclerosis. This study will involve a more advanced technique of identifying new molecules found in people who demonstrate progression of coronary atherosclerosis, heart attack and death, in the setting of a large-scale clinical trial testing a new agent that dramatically lowers cholesterol.Read moreRead less
Novel Apolipoprotein A-I Mimetic Peptides: A Research Tool And A Therapeutic Agent To Study And Treat Atherosclerosis
Funder
National Health and Medical Research Council
Funding Amount
$266,387.00
Summary
Drugs affecting lipid metabolism have revolutionized the treatment of heart diseases. There is, however, an urgent need for further reduction of high remaining risk. A most promising direction is increasing levels of _good cholesterol�. A new type of such therapy are simple compounds mimicking structure of good cholesterol. We have synthesized new such compounds that are even more active than good cholesterol. Now we will test these compounds in animals and in clinical trial.
Does Inhibition Of Myeloperoxidase Attenuate Atherosclerosis?
Funder
National Health and Medical Research Council
Funding Amount
$572,659.00
Summary
This project examines whether inhibition of a protein that produces bleach and is part of the immune system inhibits the stiffening of arteries, i.e. the major cause of cardiovascular disease that leads to heart attack and stroke. The project uses a pharmacological approach, employing a new class of chemical compounds. If successful, the project will contribute to the establishing of a novel therapeutic target to combat cardiovascular disease.