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A Biomimetic Prodrug Platform To Enable Oral Bioavailability And Target Lymphatic Disease
Funder
National Health and Medical Research Council
Funding Amount
$408,768.00
Summary
This project will allow the advance of a unique translational technology platform that provides novel drug delivery solutions. The project aims to establish the potential for a drug delivery strategy to increase the efficacy, reduce the toxicity, and transform the impact of drug therapies for a variety of conditions, including pain, hormone dysregulation, and metabolic syndrome.
Fatty Acid Elongation: A Novel Target For Prostate Cancer Treatment
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Lipids are a class of molecules that make up cell membranes and are an important source of energy for cells. Changes in lipids occur during prostate cancer progression, most prominently in a process called fatty acid elongation, which requires enzymes called elongases. This project will seek to better understand the consequences of lipid elongation in prostate cancer cells, its potential role in therapy resistance, and whether the elongase enzymes can be targeted as new therapies.
Role Of Ferroptosis In The Lipid Metabolism Of Cancer Cells
Funder
National Health and Medical Research Council
Funding Amount
$238,792.00
Summary
Conventional cancer treatments are becoming increasingly ineffective as cancers mutate to protect cells from drug-activated death. To combat this, new ways to selectively kill cancer cells must be found and therapeutically exploited. This research will study how ferroptosis, a recently discovered form of cell death that is distinct from other killing mechanisms, can be used to target cancer and provide avenues for next-generation cancer treatments.