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I am a cell /whole body integrative biologist determining the cellular and molecular mechanisms that lead to insulin resistance in insulin sensitive tissues such as skeletal muscle, liver and adipose tissue. My work primarily focuses on targeting inflammatory signalling cascades that lead to impaired insulin action, and pathways that enhance energy utilization.
Manipulation Of Energy Metabolism To Control Lipid Accumulation And Insulin Action.
Funder
National Health and Medical Research Council
Funding Amount
$804,106.00
Summary
I am a metabolic biochemist investigating how overconsumption of calories, particularly fat, results in dysfunctional energy metabolism and increased the risk of type 2 diabetes. I examine changes in the daily rhythms of energy intake, energy utilisation and energy storage in different tissues of dietary and genetically modified animals to pinpoint novel ways of reducing fat accumulation and reducing the risk of type 2 diabetes.