Gynaecological, Oesophageal And Skin Cancer In Australia: Developing The Evidence-base
Funder
National Health and Medical Research Council
Funding Amount
$6,079,935.00
Summary
Our Program addresses cancers of the ovary, uterus, oesophagus and skin (both melanoma and non-melanoma skin cancers). The first three cancers together affect almost 4,000 people and cause more than 2,000 deaths every year while skin cancer affects almost 400,000 Australians each year. Our aims are, first, to understand better how these cancers are caused so that we can try to prevent them in the future; second, to enhance diagnosis of these cancers; and third, to improve the survival and qualit ....Our Program addresses cancers of the ovary, uterus, oesophagus and skin (both melanoma and non-melanoma skin cancers). The first three cancers together affect almost 4,000 people and cause more than 2,000 deaths every year while skin cancer affects almost 400,000 Australians each year. Our aims are, first, to understand better how these cancers are caused so that we can try to prevent them in the future; second, to enhance diagnosis of these cancers; and third, to improve the survival and quality of life for people who are diagnosed with these cancers in Australia.Read moreRead less
Blue Mountains Cohort Study: Incidence Of Eye Disease, Hearing Loss And Other Health Outcomes
Funder
National Health and Medical Research Council
Funding Amount
$813,250.00
Summary
The proposed study aims to determine the cumulative 10-year incidence and progression of the major eye diseases that threaten vision in older Australians, including age-related maculopathy, cataract, glaucoma and diabetic retinopathy. The cumulative 5-year incidence of age-related hearing loss and prevalence of loss of smell will also be determined. The study will assess risk factors and associations with these diseases, using information collected at the baseline, 5-year and 10-year examination ....The proposed study aims to determine the cumulative 10-year incidence and progression of the major eye diseases that threaten vision in older Australians, including age-related maculopathy, cataract, glaucoma and diabetic retinopathy. The cumulative 5-year incidence of age-related hearing loss and prevalence of loss of smell will also be determined. The study will assess risk factors and associations with these diseases, using information collected at the baseline, 5-year and 10-year examinations on medical history, ocular factors, vascular disease, smoking, diet, plus environmental and blood factors. The study aims to assess the impact of these sensory impairments on measures of dependence, quality of life, general health, age-related cognitive impairment, depression and on mortality. The study will be conducted in Katoomba on the cohort of residents from two postcode areas who originally attended the Blue Mountains Eye Study during the period 1992-4. Examinations will commence by May, 2002 and be completed by April, 2004. We hope to examine 2,032 of the original cohort of 3,654 people. This project will build on the data already collected by the Blue Mountains Eye Study, one of the most successful community surveys conducted in Australia. The 10-year follow-up period will provide increased statistical power and precision to assess the role of possible risk factors for eye disease already identified by the earlier baseline and 5-year studies of this population. The hearing component of the study will provide the first longitudinal data on hearing loss from a large older Australian population.Read moreRead less
Anogenital Human Papillomavirus Infection And Its Outcomes In Men
Funder
National Health and Medical Research Council
Funding Amount
$333,433.00
Summary
Anal human papillomavirus (HPV) infection is common in homosexual men. Low risk types cause anal warts and high risk types of HPV cause anal cancer. This study will determine incidence and risk factors for HPV infection in a cohort of young homosexual men, the association of anal warts treatment with HIV risk, and the specific association of HPV subtypes with anal cancer. The findings of this research will help delineate the potential benefits of HPV vaccination in this population.
Understanding The Health Effects Of Biomass Smoke In Australian Towns And Cities
Funder
National Health and Medical Research Council
Funding Amount
$172,392.00
Summary
Wildfires have become more frequent and severe the world over and the health impacts of the associated air pollution is a major gap in the current evidence. Working with lead agencies in air quality regulation, public health and fire management I will examine and compare the health effects of air pollution from deliberate burns, bushfires, wood heaters and other sources of air pollution. The research will focus on respiratory and heart disease to inform public health and individual patient care.
Metabolic And Hormonal Pathways In Gynecological Cancer - Epidemiological Studies Of Risk And Survival
Funder
National Health and Medical Research Council
Funding Amount
$288,275.00
Summary
Metabolic and hormonal factors probably play a role in a womans chance of developing and surviving gynecological cancer, but the exact mechanisms are unclear. This project will use questionnaire information, blood and tumour samples of over 5,000 Australian women to examine the mechanisms leading to cancer development and survival among women with uterine and ovarian cancer, the two commonest female reproductive cancers. Results will help plan primary prevention strategies and care.
David Whiteman is a medical epidemiologist with a special interest in the causes, diagnosis, prevention and treatment of cancer. His work has focussed on melanoma and skin cancer, and more recently, on cancers of the upper gastro-intestinal tract.
Genetic And Environmental Epidemiology Of Early-onset Melanoma In The Australian Melanoma Family Study
Funder
National Health and Medical Research Council
Funding Amount
$412,210.00
Summary
This project will investigate the genetic and environmental causes of melanoma, especially melanoma developing under the age of 40 in Australian families. This project will help to identify which people are at greatest risk of developing melanoma, by identifying the genes involved in melanoma development and the contribution of environmental and lifestyle factors to the disease. We will also determine how much hereditary factors contribute to melanoma risk.