Cardiovascular Effects Of Enhanced Leptin Signalling
Funder
National Health and Medical Research Council
Funding Amount
$1,200,972.00
Summary
Leptin treatment causes weight loss, but leptin also increases blood pressure. We wish to determine if increasing leptin signalling, by modifying signal transduction pathways within leptin sensitive cells in the brain, can reduce weight without increasing blood pressure.
Diabetes Target Discovery And Drug Development In Mice And Primates
Funder
National Health and Medical Research Council
Funding Amount
$705,501.00
Summary
1.7 million Australians have diabetes, only ½ are diagnosed, and the incidence is increasing. Diabetes imposes high economic and social costs in Australia and globally. Diabetes is often not well managed with current therapies, and there is a strong need for new drugs to treat diabetes. This research project will search for new drug targets, to develop better medicines to treat diabetes.
Gastrointestinal Signals And Cardiovascular Regulation- Implications For Obesity-related Hypertension.
Funder
National Health and Medical Research Council
Funding Amount
$486,886.00
Summary
Obesity is reaching epidemic proportions, and obesity-related hypertension is the leading cause of serious cardiovascular complications. Hormones released from the gut have been implicated in obesity, but their contribution to hypertension has not been studied. Preliminary studies in our laboratory have shown that these hormones participate in signals related to cardiovascular control by acting locally to relay signals to the brain, and may be more important in obesity than previously thought.