Investigation and Development of Parallel Large Scale Record Linkage Techniques. Record linkage aims at matching records of the same entity (like customer or patient) in large (administrative) databases. The outcomes of the proposed research will improve current techniques in terms of efficiency, accuracy and the need for human intervention. Through experimental studies and stochastic modelling the performance of traditional and new methods for data cleaning, standardisation and linkage will be ....Investigation and Development of Parallel Large Scale Record Linkage Techniques. Record linkage aims at matching records of the same entity (like customer or patient) in large (administrative) databases. The outcomes of the proposed research will improve current techniques in terms of efficiency, accuracy and the need for human intervention. Through experimental studies and stochastic modelling the performance of traditional and new methods for data cleaning, standardisation and linkage will be assessed. The effect of the statistical dependency of attribute values will be studied. New methods using clustering for blocking large datasets, and predictive models including interaction terms will be implemented, analysed and evaluated on high-performance computers and office-based PC clusters.
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The Role Of Innate Inflammatory Responses In Viral Arthritis
Funder
National Health and Medical Research Council
Funding Amount
$782,514.00
Summary
Viruses are known to cause arthritis (HIV, hepatitis viruses, mosquito borne viruses). Symptoms of viral arthritis include joint pain, stiffness, and swelling. The mechanism of disease is poorly understood. We have developed a novel animal model of disease and human cell culture models by which to study disease caused by viral infections. This models provide an excellent opportunity to explore the mechanisms of rheumatic disease in a functioning animal and to explore new treatment regimes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0347223
Funder
Australian Research Council
Funding Amount
$100,000.00
Summary
Quantitative PCR facility for New England region of NSW. The project will deliver the first real-time PCR facility in the New England Region of NSW for use by University, CSIRO and Industry scientists. The facility will be based at the University of New England and be used by animal scientists, molecular biologists, parasitologists, immunologists and botanists at these institutions, in many cases in collaborative research projects. It will also support the training of seven PhD students and a po ....Quantitative PCR facility for New England region of NSW. The project will deliver the first real-time PCR facility in the New England Region of NSW for use by University, CSIRO and Industry scientists. The facility will be based at the University of New England and be used by animal scientists, molecular biologists, parasitologists, immunologists and botanists at these institutions, in many cases in collaborative research projects. It will also support the training of seven PhD students and a post-doctoral fellow. The facility will be unique to the region and will remove our current need to use facilities in Brisbane or Sydney.Read moreRead less
Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the struct ....Development of Novel Pesticidal Agents. We have discovered a family of naturally occurring plant proteins called the cyclotides that have potent insecticidal activity against Helicoverpa species, one of the major pests on cotton and corn in Australia and world wide. Preliminary evidence has shown that they also have activity against major pests to livestock in Australia, including sheep blowflies. To develop these proteins as potential pesticidal agents it is necessary to understand the structural basis for their activity. We will do this by chemically synthesising peptides with selected residues mutated to determine their effects on activity.Read moreRead less
Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is ....Nucleolus targeting by negative strand RNA viruses. Negative strand viruses (NSVs) include diverse animal pathogens that represent significant threats to Australian livestock industries and access to export markets. The project aims to investigate the interface formed by NSVs with cellular nucleoli in order to determine roles in viral manipulation of cell biology during infection. This project hopes to address a major gap in knowledge in virology regarding the fundamental biology of NSVs, and is expected to redefine our understanding of the virus-host interactions formed by these important pathogens. By determining the mechanisms of NSV-nucleolus interaction, the project plans to also provide important information for the development of new vaccines/therapeutics for livestock to combat NSVs that target nucleoli.Read moreRead less
Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would p ....Engineering a nanovaccine for cost-effective influenza poultry vaccination. The project aims to develop a new single-dose, room temperature-stable nanovaccine for cost-effective influenza poultry vaccination. The nanovaccine is based on viral protein assembly modularised to present multiple copies of influenza antigen. Particularly, this project focuses on the engineering of this vaccine manufacturing and formulation for a room temperature-stable vaccine. The resulting engineered vaccine would play an important role in preventing avian influenza outbreaks, which are currently affecting both developed and developing countries, costing millions of dollars due to the death and culling of infected poultry.Read moreRead less
Economically efficient green logistics through cyber physical systems. Economically efficient green logistics through cyber physical systems. This project aims to realize green logistics by researching how to run diesel-powered heavy-duty milk trucks economically and efficiently on liquefied natural gas (LNG) and demonstrating to logistics companies that LNG conversion will reduce operating costs and emissions. Transportation systems account for 18% of Australia's carbon emissions, and diesel-po ....Economically efficient green logistics through cyber physical systems. Economically efficient green logistics through cyber physical systems. This project aims to realize green logistics by researching how to run diesel-powered heavy-duty milk trucks economically and efficiently on liquefied natural gas (LNG) and demonstrating to logistics companies that LNG conversion will reduce operating costs and emissions. Transportation systems account for 18% of Australia's carbon emissions, and diesel-powered logistics vehicles are a major contributor. However, converting these trucks to LNG requires strong evidence to convince logistics companies of the benefits of shifting to green logistics. An increase in logistics productivity is expected to increase Australia’s gross domestic product by $2 billion, while this research should also provide vital data on sustainability issues and LNG conversions.Read moreRead less
Novel Insights Into The Mechanisms Of How Viruses Cause Arthritis-arthralgia
Funder
National Health and Medical Research Council
Funding Amount
$626,459.00
Summary
Many viruses are known to cause arthritis (e.g. HIV, hepatitis viruses, mosquito borne viruses). Symptoms of viral arthritis include joint pain, stiffness, and swelling. The mechanism of disease is poorly understood. We have developed a novel animal model of disease by which to study arthritic disease caused by viral infections. This model provides an excellent opportunity to explore the mechanisms of rheumatic disease in a complete functioning animal and to explore new treatment regimes.
Cohort discovery and activity mining for policy impact prediction. Cohort discovery and activity mining for policy impact prediction. This project aims to develop an intelligent systematic framework to predict policy impacts on Australian patients, by discovering inherent patient cohorts and assessing the impact of the policies on these cohorts. The proposed methods lay the theoretical foundations for building intelligent automated tools for policy assessment. Expected outcomes are data-driven p ....Cohort discovery and activity mining for policy impact prediction. Cohort discovery and activity mining for policy impact prediction. This project aims to develop an intelligent systematic framework to predict policy impacts on Australian patients, by discovering inherent patient cohorts and assessing the impact of the policies on these cohorts. The proposed methods lay the theoretical foundations for building intelligent automated tools for policy assessment. Expected outcomes are data-driven patient group discovery, which could more precisely identify the patient cohorts most likely to benefit from a specific policy; and a model to predict the efficacy of policy options, which could increase the sustainability of the national health system by enabling smarter, more efficient policy decision-making.Read moreRead less
Learning to Pinpoint Emerging Software Vulnerabilities. This project aims to develop learning-based software vulnerability detection techniques to improve the reliability and security of modern software systems. The existing techniques relying on conventional yet rigid software analysis and testing techniques are ineffective and/or inefficient when detecting a wide variety of emerging software vulnerabilities. The outcomes of this project will be a deep-learning-based detection approach and an ....Learning to Pinpoint Emerging Software Vulnerabilities. This project aims to develop learning-based software vulnerability detection techniques to improve the reliability and security of modern software systems. The existing techniques relying on conventional yet rigid software analysis and testing techniques are ineffective and/or inefficient when detecting a wide variety of emerging software vulnerabilities. The outcomes of this project will be a deep-learning-based detection approach and an open-source tool that can capture precision correlations between deep code features and diverse vulnerabilities to pinpoint emerging vulnerabilities without the need for bug specifications. Significant benefits include greatly improved quality, reliability and security for modern software systems.Read moreRead less