The Contributions Of Different Sources Of Calcium To The Induction Of Long Term Potentiation
Funder
National Health and Medical Research Council
Funding Amount
$267,750.00
Summary
When we make memories, we alter the strength of synaptic connections between nerve cells.These changes are particularly marked in the hippopcampus ; a region of the brain involved in the formation of memories. The strength of a synaptic connection is altered if it activates a neurone sufficiently to cause a rise in the level of calcium ions. Calcium can be derived from several sources within the neurone. This project aims to assess the relative importance of these different sources of calcium in ....When we make memories, we alter the strength of synaptic connections between nerve cells.These changes are particularly marked in the hippopcampus ; a region of the brain involved in the formation of memories. The strength of a synaptic connection is altered if it activates a neurone sufficiently to cause a rise in the level of calcium ions. Calcium can be derived from several sources within the neurone. This project aims to assess the relative importance of these different sources of calcium in inducing increases in synaptic strength.Read moreRead less
Preventing Academic Difficulties In Preterm Children: An Adaptive Working Memory Training Intervention.
Funder
National Health and Medical Research Council
Funding Amount
$711,566.00
Summary
Preterm children exhibit high rates of learning disability which has considerable social and economic consequences. It is proposed that these learning difficulties are related to reduced working memory capacity. This randomised controlled trial will investigate the ability of an established working memory training program to improve academic functioning and prevent learning disability in children born extremely preterm. Neuroimaging will be performed to study functional neuroplasticity associate ....Preterm children exhibit high rates of learning disability which has considerable social and economic consequences. It is proposed that these learning difficulties are related to reduced working memory capacity. This randomised controlled trial will investigate the ability of an established working memory training program to improve academic functioning and prevent learning disability in children born extremely preterm. Neuroimaging will be performed to study functional neuroplasticity associated with improved working memory capacity.Read moreRead less
Preventing Early Academic Problems By Improving Working Memory: Translational Randomised Trial
Funder
National Health and Medical Research Council
Funding Amount
$831,085.00
Summary
Learning difficulties are common and can cause school failure and poor self-esteem. They are associated with specific problems with temporarily remembering and using information (‘working memory’). Research suggests that improving working memory might improve academic achievement. We will study this intervention in a large group of primary school children who have poor working memory. If successful, the intervention will provide a way to improve the learning skills of these high-risk children.
Modelling Adversarial Noise for Trustworthy Data Analytics. Adversarial robustness is a core property of trustworthy machine learning. This project aims to equip machines with the ability to model adversarial noise for defending adversarial attacks. The project expects to produce the next great step for artificial intelligence – the potential to robustly explore and exploit deceptive data. Expected outcomes of this project include theoretical foundations for modelling adversarial noise and the n ....Modelling Adversarial Noise for Trustworthy Data Analytics. Adversarial robustness is a core property of trustworthy machine learning. This project aims to equip machines with the ability to model adversarial noise for defending adversarial attacks. The project expects to produce the next great step for artificial intelligence – the potential to robustly explore and exploit deceptive data. Expected outcomes of this project include theoretical foundations for modelling adversarial noise and the next generation of intelligent systems to accommodate data in a noisy and hostile environment. This should benefit science, society, and the economy nationally and internationally through the applications to trustworthily analyse their corresponding complex data. Read moreRead less
Quantum Generative Diffusion Models for Molecular Research. This project will devise quantum generative diffusion models to equip classical counterparts with the ability to harness quantum data that naturally arise in molecular research. Theoretical foundations for analysing fast sampling methods with the help of inductive bias regarding the input data and employed circuits will validate efficient quantum generative diffusion models that have training and sampling advantages over classical count ....Quantum Generative Diffusion Models for Molecular Research. This project will devise quantum generative diffusion models to equip classical counterparts with the ability to harness quantum data that naturally arise in molecular research. Theoretical foundations for analysing fast sampling methods with the help of inductive bias regarding the input data and employed circuits will validate efficient quantum generative diffusion models that have training and sampling advantages over classical counterparts. Outcomes include applications in molecular conformation generation, compound screening, and drug design. The innovative research will significantly benefit Australia’s science, industry and health, and will maintain Australia’s global leading role in quantum machine learning and molecular research.Read moreRead less
The amygdala is an area of the brain that is involved in assigning emotional content to sensory information. Disorders of the amygdala lead to a variety of anxiety-related mental disorders such as panic attacks and post-traumatic stress. This grant will study how the NMDA receptor, which plays a central role in memory formation, works in the amygdala. We will determine the functional role of this receptor in the amygdala and how it may be modified by experience.
Optimising students’ academic trajectories: The role of growth (‘personal best’) goals. Too many students fail to reach their academic potential and, as a result, they risk being systematically denied a sense of academic ‘success’ and progress. Through a focus on academic growth (and ‘personal bests’), this research project traverses complex terrain to identify the role of growth goals and growth goal setting in students’ academic trajectories. It also tackles methodological challenges that have ....Optimising students’ academic trajectories: The role of growth (‘personal best’) goals. Too many students fail to reach their academic potential and, as a result, they risk being systematically denied a sense of academic ‘success’ and progress. Through a focus on academic growth (and ‘personal bests’), this research project traverses complex terrain to identify the role of growth goals and growth goal setting in students’ academic trajectories. It also tackles methodological challenges that have impeded research progress in this compelling area. Through strategic international and institutional links, the research program will identify innovative approaches to academic growth and growth goals that will significantly assist pedagogy and psychology aimed at optimising students’ academic potential.Read moreRead less
The Extinction Of Conditioned Fear And Its Implications For Cue Exposure Therapy
Funder
National Health and Medical Research Council
Funding Amount
$322,430.00
Summary
This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavl ....This project studies extinction of Pavlovian conditioned fear reactions in rats. Extinction of these reactions is an animal model for exposure therapy used in the treatment of anxiety disorders in people. In exposure therapy, the patient, aided by the clinician, confronts trauma-related cues in the absence of any overt danger. The intention of this therapy is to reduce the ability of the trauma-related cues to provoke the fear reactions that are undermining the patient's quality of life. In Pavlovian conditioning, subjects (typically rats) are exposed to a signaling relation between an initially neutral stimulus (e.g., a noise) and a feared outcome (e.g., foot shock). When later repeatedly exposed to the initially neutral but now feared stimulus (the noise) in the absence of the feared outcome, the fear reactions it acquired progressively decline until eventually it fails to elicit any such reactions. The fear reactions are said to have been extinguished. There has been significant progress in understanding the psychological processes and neural mechanisms underlying the acquisition of fear reactions, but much less is known about the processes and mechanisms underlying the extinction of these reactions. The project has two general objectives. The first is to determine the conditions of extinction training that promote long-term loss of fear reactions. The second objective is to determine how the brain controls this extinction of learned fear. Achieving these aims will be significant for two reasons. First, it will contribute to understanding the mechanisms by which animals (including people) learn to adjust their behaviour to bring it into line with the current relations that exist between events in the world. Second, it will provide important information about how such adjustment is facilitated or impaired across extinction training and, thereby, contribute towards understanding both the successes and failures of cue exposure therapy for fear-related disorders.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100495
Funder
Australian Research Council
Funding Amount
$422,154.00
Summary
Structured Federated Learning for Personalised Intelligence on Devices. The project aims to develop a new structured federated machine-learning framework to enhance the customisation of artificial intelligence across mobile and smart devices. It seeks to enable users to receive customised services on their devices without sending their sensitive personal data to a cloud service provider. Anticipated benefits include greater privacy, data security and device performance, as well as better end-use ....Structured Federated Learning for Personalised Intelligence on Devices. The project aims to develop a new structured federated machine-learning framework to enhance the customisation of artificial intelligence across mobile and smart devices. It seeks to enable users to receive customised services on their devices without sending their sensitive personal data to a cloud service provider. Anticipated benefits include greater privacy, data security and device performance, as well as better end-user experience. Expected outcomes of this research include new knowledge, toolkits and algorithms for use in developing machine-learning based secure, efficient and fault-tolerant technologies for software applications, mobile services, cloud computing, autonomous vehicles and advanced manufacturing processes.Read moreRead less