Stimulus fear-relevance: Exploring the boundaries of preferential attentional processing. The present project will contribute to our knowledge about the manner in which emotionally salient events are processed. It will test predictions from a current, influential theory of anxiety and in doing so, inform our understanding of information processing in psychopathology. Investigation of these basic questions can have implications for the design of therapeutic interventions. Moreover, the presen ....Stimulus fear-relevance: Exploring the boundaries of preferential attentional processing. The present project will contribute to our knowledge about the manner in which emotionally salient events are processed. It will test predictions from a current, influential theory of anxiety and in doing so, inform our understanding of information processing in psychopathology. Investigation of these basic questions can have implications for the design of therapeutic interventions. Moreover, the present project will provide the opportunity for research training for undergraduate and post graduate students. In doing so, it will enhance the quality of our culture and contribute to the discipline of psychology.Read moreRead less
Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of t ....Testing the ghost with the machine: Empirical investigations of cognition using high-field functional magnetic resonance imaging. The primary aim of the project is to test hypotheses about the cognitive architecture of word production and negative priming using high-field functional magnetic resonance imaging (fMRI). Additional aims/outcomes are to apply a novel fMRI acquisition sequence that permits overt verbal responding with rapid presentation of trials and collection of the time course of the blood oxygen level dependent (BOLD) signal, and to further develop a methodology that delineates the logic of making inferences about cognitive systems from functional neuroimaging data. These represent potentially significant developments in the fields of cognitive neuroscience and functional neuroimaging.Read moreRead less
Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage an ....Mechanisms of fear learning and extinction in the mammalian brain. The brain is a remarkable machine that coordinates all aspects of our daily lives including the storage and retrieval of memories. Given that many age-related degenerative disorders are associated with marked changes in learning and memory it also has implications for Australia's National Research Priority 2 "Ageing well and ageing productively". This research aims to discover the basic mechanisms that underlie memory storage and how these are modulated in an emotional context. It will also shed light on states such as anxiety, depression and post-traumatic stress, enhancing our ability to identify new therapeutic targets for such disorders.Read moreRead less
Biased information processing in anxiety: Low anxiety scores, but still at risk. Information processing in anxious persons is biased if confronted with threatening stimulus materials such as words or pictures. This finding has considerable implications for our understanding of fear acquisition and maintenance and for the design of therapeutic interventions. More recent research has shown, however, that low anxious persons who employ repressive coping styles show similar biases. The present proj ....Biased information processing in anxiety: Low anxiety scores, but still at risk. Information processing in anxious persons is biased if confronted with threatening stimulus materials such as words or pictures. This finding has considerable implications for our understanding of fear acquisition and maintenance and for the design of therapeutic interventions. More recent research has shown, however, that low anxious persons who employ repressive coping styles show similar biases. The present project will follow up on these findings by combining the expertises of the two CIs in contemporary cognitive and psychophysiological research. It will not only provide new insights, but also offer research opportunities for postgraduate students, and prospects for future collaborative funding.Read moreRead less
Human learning of likes and dislikes: A test of the dual process account and an investigation of its neural substrates. Dual process accounts of human affective learning hold that affective learning, the learning of likes and dislikes, and relational learning, the learning of predictive relationships, reflect separate learning mechanisms. Affective learning, for instance, is said not to extinguish, a claim that has far reaching consequences for the design of behaviourally based treatments of a ....Human learning of likes and dislikes: A test of the dual process account and an investigation of its neural substrates. Dual process accounts of human affective learning hold that affective learning, the learning of likes and dislikes, and relational learning, the learning of predictive relationships, reflect separate learning mechanisms. Affective learning, for instance, is said not to extinguish, a claim that has far reaching consequences for the design of behaviourally based treatments of anxiety. The project will test this and other predictions of dual process accounts. Moreover, it will extent the experimental analysis of affective learning to the acquisition of likes and identify the cortical bases for aversive, appetitive, and relational learning using event related functional magnetic resonance imaging.Read moreRead less
Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. ....Cellular Plasticity in the Brain: discovering molecular mechanisms controlling the production of neurons during brain development, function, ageing and disease. The program aims to understand the mechanisms regulating Brain Plasticity - this recently discovered property of the brain to respond to environmental stimuli, both physiological and pathological, by producing new functional neurons. Specifically, the program will discover how the brain's stem cells are stimulated to produce new neurons. This understanding will significantly expand our knowledge of how the brain develops, and how functions, like memory, are modulated by neuronal replacement. Discoveries will underpin the development of, in association with Australia's biotechnology sector, a new generation of therapeutics, which treat neurological diseases, like Stroke, by stimulating the production of functional neurons.Read moreRead less