Linkage Infrastructure, Equipment And Facilities - Grant ID: LE0668421
Funder
Australian Research Council
Funding Amount
$650,000.00
Summary
A MEG-based cognitive neuroscience laboratory. At present there is no MEG system in Australia, whereas MEG systems are currently springing up in research institutions in many other countries across the globe. This project will enable Australia to remain at the forefront of research in the cognitive neurosciences, as well as provide training opportunities to Australian doctoral students and postdoctoral fellows in the use of MEG in research. Finally, the MEG laboratory will allow Australian resea ....A MEG-based cognitive neuroscience laboratory. At present there is no MEG system in Australia, whereas MEG systems are currently springing up in research institutions in many other countries across the globe. This project will enable Australia to remain at the forefront of research in the cognitive neurosciences, as well as provide training opportunities to Australian doctoral students and postdoctoral fellows in the use of MEG in research. Finally, the MEG laboratory will allow Australian researchers to fill important gaps in our understanding of several areas of cognitive neuroscience, including basic auditory and visual processing, the study of cognitive processing in schizophrenia and in children with dyslexia and/or specific language impairment.Read moreRead less
Establishing how head and face movement properties contribute to the perception of speech and identity. The proposed studies provide an extensive research program into audio-visual speech processing and person identification: key components of face-to-face communication. The likely impact and benefits of the project concern its contribution to perceptual theory (linking signal, brain and behaviour) and its practical implications: For determining the viability of multimodal biometric identificati ....Establishing how head and face movement properties contribute to the perception of speech and identity. The proposed studies provide an extensive research program into audio-visual speech processing and person identification: key components of face-to-face communication. The likely impact and benefits of the project concern its contribution to perceptual theory (linking signal, brain and behaviour) and its practical implications: For determining the viability of multimodal biometric identification procedures by assessing the distinctiveness and permanence of AV speech characteristics. In the development of a visual dubbing technique that has potential for communication in noisy environments (and for the deaf) and for the development of a morphable model for AV presentation that has application for both first and second language learning.Read moreRead less
Elucidating the mechanisms by which Scribble, Discs Large and Lethal Giant Larvae regulate epithelial polarity. Discs Large (Dlg) and Scribble are proteins that regulate cell shape by concentrating at particular regions within the cell and recruiting other proteins to that region. It is thought that the two proteins interact with each other, and with other proteins involved in protein trafficking and cell architecture, but it is not known how these events coordinate to produce a net outcome on ....Elucidating the mechanisms by which Scribble, Discs Large and Lethal Giant Larvae regulate epithelial polarity. Discs Large (Dlg) and Scribble are proteins that regulate cell shape by concentrating at particular regions within the cell and recruiting other proteins to that region. It is thought that the two proteins interact with each other, and with other proteins involved in protein trafficking and cell architecture, but it is not known how these events coordinate to produce a net outcome on cell shape. To answer these questions, the dynamic events involved in localization of Dlg, Scribble, and associated proteins will be determined, in mammalian cells and in whole organs of the vinegar fly.Read moreRead less
Mobility of log-dependent invertebrates in fragmented forest. Clearing of Australian native forests continues apace. This leads to declines in total forest area and creates isolated remnants with depleted woody debris. Critical forest processes driven by invertebrates occur in this debris. Despite its major economic and conservation significance, there is little information on the impacts of habitat loss and alteration on organisms in decomposing logs. We will utilize recent advances in popu ....Mobility of log-dependent invertebrates in fragmented forest. Clearing of Australian native forests continues apace. This leads to declines in total forest area and creates isolated remnants with depleted woody debris. Critical forest processes driven by invertebrates occur in this debris. Despite its major economic and conservation significance, there is little information on the impacts of habitat loss and alteration on organisms in decomposing logs. We will utilize recent advances in population genetics to compare impacts on a suite of log-dependent invertebrates in an islands-of-bush-in-a-sea-of-pines model. This will facilitate improvements in conservation and sustainable management outcomes in forests.Read moreRead less
Population genetic structure and habitat specialisation in amphibians. This will be the first study to uncover the initial stages of ecological speciation in a fully natural setting, which will solidify Australia's leading position in evolutionary biology. The project promotes active international collaboration and bolsters the vibrant intellectual community here at home. Many Australian undergraduate and PhD students will participate in cutting-edge science and develop connections with overseas ....Population genetic structure and habitat specialisation in amphibians. This will be the first study to uncover the initial stages of ecological speciation in a fully natural setting, which will solidify Australia's leading position in evolutionary biology. The project promotes active international collaboration and bolsters the vibrant intellectual community here at home. Many Australian undergraduate and PhD students will participate in cutting-edge science and develop connections with overseas colleagues, helping Australia maintain its prominent international reputation in the future. The work also advances knowledge and appreciation of the natural world - a more urgent objective now than ever before. Ecological information is especially critical for amphibians, many of which are declining in Australia.Read moreRead less
Structural investigations into the regulation of programmed cell death. One in three men and one in four women in Australia will develop cancer by the age of 75 at current incidence rates. At its heart, cancer is a disease of uncontrolled cell proliferation. One of the body's main defence mechanisms against excess cell proliferation is Programmed Cell Death, a process which becomes dysfunctional in cancer cells. This work will provide three dimensional images of the machinery that controls Progr ....Structural investigations into the regulation of programmed cell death. One in three men and one in four women in Australia will develop cancer by the age of 75 at current incidence rates. At its heart, cancer is a disease of uncontrolled cell proliferation. One of the body's main defence mechanisms against excess cell proliferation is Programmed Cell Death, a process which becomes dysfunctional in cancer cells. This work will provide three dimensional images of the machinery that controls Programmed Cell Death. This information is critical for the development of drugs designed to re-initiate Programmed Cell Death in cancer cells.Read moreRead less
Regulation and function of a novel protein tyrosine phosphatase. A cell's ability to respond to its extracellular environment involves a complex and highly organised series of events referred to as cellular signalling. These signalling processes regulate fundamental cellular processes that underlie the growth and development of all living organisms. This proposal focuses on a group of enzymes known as the protein tyrosine phosphatases and their ability to regulate tyrosine phosphorylation-depe ....Regulation and function of a novel protein tyrosine phosphatase. A cell's ability to respond to its extracellular environment involves a complex and highly organised series of events referred to as cellular signalling. These signalling processes regulate fundamental cellular processes that underlie the growth and development of all living organisms. This proposal focuses on a group of enzymes known as the protein tyrosine phosphatases and their ability to regulate tyrosine phosphorylation-dependent signalling. We have identified a novel human protein tyrosine phosphatase and we aim to characterise its regulation and biological function.Read moreRead less
Characterisation of a novel protein tyrosine phosphatase. A cells ability to respond to its extracellular environment involves a complex and highly organised series of events referred to as cellular signalling. These signalling processes regulate fundamental cellular events that underlie the growth and development of all living organisms. This proposal focuses on a group of enzymes known as the protein tyrosine phosphatases and their ability to regulate tyrosine phosphorylation-dependent signa ....Characterisation of a novel protein tyrosine phosphatase. A cells ability to respond to its extracellular environment involves a complex and highly organised series of events referred to as cellular signalling. These signalling processes regulate fundamental cellular events that underlie the growth and development of all living organisms. This proposal focuses on a group of enzymes known as the protein tyrosine phosphatases and their ability to regulate tyrosine phosphorylation-dependent signalling. We have identified a novel human protein tyrosine phosphatase and we aim to characterise its function and the mechanism by which it is regulated.Read moreRead less
Colour polymorphisms and speciation: linking macroevolutionary patterns with microevolutionary processes. Polymorphic species with many different colour forms have inspired biological inquiry since Aristotle. This project takes advantage of remarkable variation in male throat coloration in the South Australian tawny dragon lizard to contribute to a fundamental, yet unresolved, question in biology: what are the evolutionary processes generating biodiversity? This research will reinforce Australia ....Colour polymorphisms and speciation: linking macroevolutionary patterns with microevolutionary processes. Polymorphic species with many different colour forms have inspired biological inquiry since Aristotle. This project takes advantage of remarkable variation in male throat coloration in the South Australian tawny dragon lizard to contribute to a fundamental, yet unresolved, question in biology: what are the evolutionary processes generating biodiversity? This research will reinforce Australia's outstanding reputation in the fields of Ecology and Evolution and contribute to the training of internationally competitive postgraduate students. It will also improve our understanding of the biology and genetic diversity of a fascinating Australian reptile and its habitat, within a region of national biodiversity significance.Read moreRead less
The success and rapid evolution of invasive species: resolving a genetic paradox. Invasive species have an enormous economic impact on trade, agriculture, aquaculture, fisheries and eco-tourism in Australia. In order to negate such detrimental impacts, integrated strategies need to be formulated to effectively control and eradicate introduced species. Our limited knowledge of the factors underlying the success of invasive species has hampered such efforts. A detailed understanding of the invasio ....The success and rapid evolution of invasive species: resolving a genetic paradox. Invasive species have an enormous economic impact on trade, agriculture, aquaculture, fisheries and eco-tourism in Australia. In order to negate such detrimental impacts, integrated strategies need to be formulated to effectively control and eradicate introduced species. Our limited knowledge of the factors underlying the success of invasive species has hampered such efforts. A detailed understanding of the invasion dynamics of introduced species is essential for identifying potential weaknesses that can be exploited in management strategies. My research will examine the invasion dynamics of a successful invasive species, the delicate skink, providing information directly relevant to the management of introduced species in Australia.Read moreRead less