The Ongoing Evolution Of Class 1 Integrons And The Recruitment Of New Resistance And Virulence Genes Into Pathogens
Funder
National Health and Medical Research Council
Funding Amount
$526,878.00
Summary
Bacteria are remarkably adaptive and evolve in ways that plants and animals do not. One of these ways is Lateral Gene Transfer (LGT), a process allowing one bacterial cell in a community to give genes that have been developed or acquired to other members of the community. This is a process that has led to the problem of multi drug resistance. This project aims to understand and thereby limit the movement of resistance genes from harmless bacteria into those that cause disease in humans.
Integrons, Mobile Gene Cassettes And Pathogencity In Vibrio Cholerae
Funder
National Health and Medical Research Council
Funding Amount
$550,285.00
Summary
Bacteria are remarkably adaptive and evolve in ways that plants and animals do not. One of these ways is Lateral Gene Transfer or LGT, which is a process allowing bacterial cells to share genes. Such mobile genes can greatly influence the extent to which pathogenic bacteria can cause disease. One notable example is Vibrio cholerae where many strains can be benign but some can give rise to cholera pandemics. Here, we will investigate this phenomenon in this important bacterium.