Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100013
Funder
Australian Research Council
Funding Amount
$600,000.00
Summary
Nyingarn: a platform for primary sources in Australian Indigenous languages. This project aims to build Nyingarn, an online platform of digital text versions of early Australian Indigenous language manuscripts with images of the original documents. There are over a thousand such documents that are foundational to understanding Australia's languages, and Nyingarn makes textual versions, accessions, and navigates such documents, with a means for adding more in future. Expected outcomes of this pro ....Nyingarn: a platform for primary sources in Australian Indigenous languages. This project aims to build Nyingarn, an online platform of digital text versions of early Australian Indigenous language manuscripts with images of the original documents. There are over a thousand such documents that are foundational to understanding Australia's languages, and Nyingarn makes textual versions, accessions, and navigates such documents, with a means for adding more in future. Expected outcomes of this project are accessible sources useful for educational materials, and for understanding the local language, its history, and its relationship to other languages. Nyingarn will provide cutting-edge methods for ingesting, analysing, and presenting these historical materials, both for research and for the general public.Read moreRead less
Development Of Iron Complexes For The Treatment Of FriedreichÍs Ataxia & The Role Of Frataxin In Iron Metabolism
Funder
National Health and Medical Research Council
Funding Amount
$616,143.00
Summary
Friedreich's ataxia (FA) is a neuro- & cardio-degenerative disease where there is an accumulation of toxic iron (Fe) in the mitochondrion. Work from our current NHMRC grant showed iron plays a significant role in FA pathology In fact, the CIs dissected the mechanisms of mitochondrial iron-loading & have published 8 papers in high impact journals with 3 papers in PNAS USA in the last 2 yrs Understanding of this process has led to the design of rationalised drugs for FA This work in this Renewal c ....Friedreich's ataxia (FA) is a neuro- & cardio-degenerative disease where there is an accumulation of toxic iron (Fe) in the mitochondrion. Work from our current NHMRC grant showed iron plays a significant role in FA pathology In fact, the CIs dissected the mechanisms of mitochondrial iron-loading & have published 8 papers in high impact journals with 3 papers in PNAS USA in the last 2 yrs Understanding of this process has led to the design of rationalised drugs for FA This work in this Renewal could lead to novel therapies for FARead moreRead less
New approaches measuring Australia’s creative workforce: Beyond the Census . This project aims to develop new approaches to measuring Australia’s creative workforce to address increasingly urgent questions about the value of this growing but poorly understood part of the economy and society. It expects to develop and demonstrate novel methods for capturing a range of creative activity currently at the margins of traditional measurement typified by the Census. Expected outcomes, which will benefi ....New approaches measuring Australia’s creative workforce: Beyond the Census . This project aims to develop new approaches to measuring Australia’s creative workforce to address increasingly urgent questions about the value of this growing but poorly understood part of the economy and society. It expects to develop and demonstrate novel methods for capturing a range of creative activity currently at the margins of traditional measurement typified by the Census. Expected outcomes, which will benefit industry partners, the cultural and creative industries, and international scholarship, include new understandings of the scope of creative qualifications, the contribution of creatives working outside the creative industries, the extent of second and other incomes, and the value of volunteering and online entrepreneurship.Read moreRead less
Glycotherapeutics; A New Class Of Treatment For Alphavirus-induced Musculoskeletal Disease
Funder
National Health and Medical Research Council
Funding Amount
$449,868.00
Summary
The hallmark of alphavirus disease is crippling pain and joint arthritis, which often has an extended duration. Currently there is no licenced specific treatment for alphavirus disease and the increasing spread of infection highlights an urgent need for therapeutic intervention strategies. This grant looks at the potential of pentosan polysulfate as a promising drug-repurposing candidate for the treatment of alphavirus-induced arthritis.
Special Research Initiatives - Grant ID: SR1101002
Funder
Australian Research Council
Funding Amount
$21,000,000.00
Summary
Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and ....Stem Cells Australia. Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw upon strengths within Australia’s premier stem cell research universities and institutes. This collaboration between leading bioengineering, nanotechnology, stem cell and advanced molecular analysis experts, will fast-track efforts to deliver a fundamental understanding of the mechanisms of stem cell regulation and differentiation, and the ability to control and influence this process. Stem Cells Australia will deliver new methods for stem cell propagation and manipulation, new translational technologies for therapeutic applications, and will prepare Australia’s future stem cell scientific leaders.Read moreRead less
Discovering a ‘good read’: Pathways to reading for Australian teens. This project aims to support the school, library, and book industries to increase teenagers’ recreational reading. Matching the right book to the right reader is essential to increase young people’s motivation to read. Yet how cultural intermediaries should operate to best effect within the complex ecologies that shape young people’s text selection is unclear. The project expects to generate robust evidence on how teens discove ....Discovering a ‘good read’: Pathways to reading for Australian teens. This project aims to support the school, library, and book industries to increase teenagers’ recreational reading. Matching the right book to the right reader is essential to increase young people’s motivation to read. Yet how cultural intermediaries should operate to best effect within the complex ecologies that shape young people’s text selection is unclear. The project expects to generate robust evidence on how teens discover books and the cultural factors that influence their choices. Expected outcomes include strategies that libraries, schools, and the book industry can use to promote Australian content for young adults, and equip young people to participate more fully in the social and economic benefits of pleasure reading.Read moreRead less
Effective clinical handover communication: improving patient safety, experiences and outcomes. Communication in clinical handover (transfer of responsibility for patient care) plays a causal role in many adverse events. This project will contribute new knowledge for improvements in handover communication which will be shared across hospitals and health departments nationally to improve patient safety and reduce healthcare costs.
ARC Centre of Excellence for Indigenous and Environmental Histories and Futures. ARC Centre of Excellence for Indigenous and Environmental Histories and Futures. The proposed Centre aims to generate a new direction in knowledge creation based on Aboriginal- and Torres Strait Islander-led approaches to managing Land and Sea Country. The Centre expects to make a legacy contribution by developing complementary Indigenous and Western knowledge frameworks for modelling environmental, cultural, and hi ....ARC Centre of Excellence for Indigenous and Environmental Histories and Futures. ARC Centre of Excellence for Indigenous and Environmental Histories and Futures. The proposed Centre aims to generate a new direction in knowledge creation based on Aboriginal- and Torres Strait Islander-led approaches to managing Land and Sea Country. The Centre expects to make a legacy contribution by developing complementary Indigenous and Western knowledge frameworks for modelling environmental, cultural, and historical change in Australia over the last millennium and into the near future. Expected outcomes focus on sustainable Indigenous land and sea management planning for future decades. Benefits include improved forecasting of the trajectory of environmental change, an increase in the capacity of Indigenous research, creation of a pipeline for Indigenous students into research, and evidence-based policy-making.Read moreRead less
New Insights Into Viral Inflammatory Disease Mechanisms And Approaches To Therapy
Funder
National Health and Medical Research Council
Funding Amount
$631,010.00
Summary
This fellowship aims to establish how viruses cause disease, including how they evade the immune response to persist and cause disease for prolonged periods. My vision is that knowing how the virus and the immune system interact to determine disease severity will assist in devising new treatments and prevention programs to lessen the impact of viral diseases in Australia and worldwide.
ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision system ....ARC Centre of Excellence - Vision Science. This Centre will generate important new knowledge of the performance, logic and stability of vision and visual behaviour. This knowledge will help reduce the burden of vision impairment in Australia, increasing productivity, promoting healthy ageing and reducing the community costs of visual impairment (ca. $9.85 billion in 2004). The knowledge produced will also make possible world-class innovations in robotics, leading to novel automated vision systems with applications in industry and national security. Other knowledge will develop novel diagnostic technologies, for application in health delivery.Read moreRead less