Discovery Early Career Researcher Award - Grant ID: DE210100934
Funder
Australian Research Council
Funding Amount
$439,082.00
Summary
Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expect ....Taming the light: full control in polarisation, space, and time. This project aims to develop two prototype optical beam shaping systems, culminating in the demonstration of new high-power optical fibre amplifiers. This novel ability to control all the properties of light enables the generation of optical beams that were only theoretical ideas but never previously implemented experimentally. This advanced technology can potentially open new ways in which objects can be probed using light. Expected outcomes include the creation of an optical platform that the optical community at large may utilise for their specific applications. Besides the intellectual property benefits of such optical devices directly, this project should bridge the gap between the developed knowledge and commercial opportunities.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
High shear fluid flow driving carbon foundry for advanced manufacturing. This project aims to develop versatile continuous flow thin film microfluidic device technology for harnessing contact electrification generated by sub-micron high shear flows in fabricating novel and high-performance nano-carbons for which current methods are ineffective or impossible. This project expects to generate new knowledge on complex vortex fluid fields, their intricate interactions with external electric and magn ....High shear fluid flow driving carbon foundry for advanced manufacturing. This project aims to develop versatile continuous flow thin film microfluidic device technology for harnessing contact electrification generated by sub-micron high shear flows in fabricating novel and high-performance nano-carbons for which current methods are ineffective or impossible. This project expects to generate new knowledge on complex vortex fluid fields, their intricate interactions with external electric and magnetic fields and carbon nanostructure formation. Expected outcomes for this project include exquisite control on reforming nanocarbon with tuneable properties and unprecedented hetero-structures. This should provide significant benefits, such as in generating new processes and products for advanced manufacturing. Read moreRead less
Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drive ....Creating a non-invasive window into the mind. This project aims to create better tools to study the human mind. This project expects to generate new knowledge that can be used to non-invasively image neuronal activity. Expected outcomes include the development of unique new Magnetic Resonance Imaging (MRI) instruments to study neuronal activity in both highly controlled laboratory conditions and in humans, with the spatial and temporal resolution needed to study the neuronal circuitry that drives low and high-level brain functions, i.e., creating a window into the mind. In the future, outcomes from this study could improve our understanding of mental disorders, advance computer brain interface technology, and inspire the next paradigm shift in artificial intelligence.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Cell–fluid interaction: inside and outside cells. The project aims to measure mechanics at the cellular level using a combination of optical tweezers for measurement of nano-scale environment around/inside cells and light-sheet microscopy for imaging. The project expects to generate new knowledge about movement of cells through their environment, relating to collective behaviour which is of importance in understanding infections and formation of biofilms. Expected outcomes include deepened under ....Cell–fluid interaction: inside and outside cells. The project aims to measure mechanics at the cellular level using a combination of optical tweezers for measurement of nano-scale environment around/inside cells and light-sheet microscopy for imaging. The project expects to generate new knowledge about movement of cells through their environment, relating to collective behaviour which is of importance in understanding infections and formation of biofilms. Expected outcomes include deepened understanding of an enigmatic process conserved from amoebae to humans, by which cells ‘drink and eat’ by ‘gulping’ fluid and supplement their nutrient intake by degrading proteins and cell debris. It will generate new knowledge of these processes to better understand how mechanics affects cellular life.Read moreRead less
A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interac ....A Micro-Physiological System to Mimic Human Microbiome-Organ Interactions. This project aims to mimic gut microbiome-organ interactions by developing a microbial-gut coculture chip, which can reversibly interface with other organs-on-chips. This is achieved through the systematic integration of highly customisable biofabrication and microfluidic technologies. This project fills a critical technological gap in the availability of an animal-alternative system to investigate microbiome-host interactions, which will greatly complement existing meta-omics approaches. The deliverables include a proof-of-concept system validated for gut-liver axis as well as the creation of new knowledge and framework to assimilate design thinking and advanced manufacturing to elevate tissue engineering into physiology engineering. Read moreRead less
Analysis of asteroid samples returned by Hayabusa 2 and Osiris-REx . This year sees the highly anticipated return of the Hayabusa2 spacecraft to Woomera carrying samples of the asteroid Ryugu. This is only the fifth extraterrestrial sample return mission in history. The research team has been invited to participate in the preliminary examination which will take place in Japan in early 2021. The investigators have developed unique analytical skills that allow measurement of small amounts of rock ....Analysis of asteroid samples returned by Hayabusa 2 and Osiris-REx . This year sees the highly anticipated return of the Hayabusa2 spacecraft to Woomera carrying samples of the asteroid Ryugu. This is only the fifth extraterrestrial sample return mission in history. The research team has been invited to participate in the preliminary examination which will take place in Japan in early 2021. The investigators have developed unique analytical skills that allow measurement of small amounts of rock for oxygen isotope compositions at unprecedented precision. This project aims to characterise a suite of carbonaceous chondrites, which appear to be the best match to Ryugu, and therefore will provide the exemplar data to understand the provenance of Ryugu, and place it in the context of solar system materials.
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A New Nano Tip Fabrication Technique for Atomic Force Microscopy. This project aims to develop a new fabrication technique for high-aspect-ratio (long and sharp) tips for atomic force microscopy. The technique is expected to overcome the current fabrication limitation, that is fabricating one tip at a time which is unsuitable for batch fabrication. The proposed technique can be scaled up to mass produce nano tips. The technique is expected to create new commercial products and intellectual prope ....A New Nano Tip Fabrication Technique for Atomic Force Microscopy. This project aims to develop a new fabrication technique for high-aspect-ratio (long and sharp) tips for atomic force microscopy. The technique is expected to overcome the current fabrication limitation, that is fabricating one tip at a time which is unsuitable for batch fabrication. The proposed technique can be scaled up to mass produce nano tips. The technique is expected to create new commercial products and intellectual property. This innovation will lead to the emergence of breakthrough technologies in nanofabrication and nanomaterials synthesis. The benefits to Australia include new job opportunities and the development of local expertise in the field.Read moreRead less
Innovative Electrohydrodynamic Atomisation for Improved Nasal Drug Delivery. Inhalation offers high and rapid drug absorption into the bloodstream. This project aims to establish key technologies for a revolutionary system in inhaled nanomedicine delivery. The study will investigate the underlying physics of nanoparticles to create a world-first electrostatic nebuliser, enabling the more effective drug delivery. This technique is expected to overcome the current limitations by providing better c ....Innovative Electrohydrodynamic Atomisation for Improved Nasal Drug Delivery. Inhalation offers high and rapid drug absorption into the bloodstream. This project aims to establish key technologies for a revolutionary system in inhaled nanomedicine delivery. The study will investigate the underlying physics of nanoparticles to create a world-first electrostatic nebuliser, enabling the more effective drug delivery. This technique is expected to overcome the current limitations by providing better control over the size and charge of delivered drugs. The outcomes of this project will benefit pharmaceutical companies in developing products with more efficient nasal delivery of advanced drugs, vaccines, and nanocariers, make it easier for doctors to prescribe, and benefit patients with more accurate dosages.Read moreRead less