Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment an ....Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment and quantification of dynamic structural remodelling that occurs, providing key targets to improve tissue engineering strategies. The project will also drive innovation in micromechanical testing technology, deliver functional solutions in mechanobiology and advance materials for biological integration.Read moreRead less
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Agile synthesizers for quantum computing, simulation and sensing. The project aims to develop breakthrough technology for generating the complex radio and microwave pulses that underpin the revolution in quantum computing and quantum sensing. Quantum technologies are rapidly emerging from laboratory to real-world applications including neural imaging, defence surveillance, and mining exploration, but further advances require increased precision and flexibility in controlling the quantum states ....Agile synthesizers for quantum computing, simulation and sensing. The project aims to develop breakthrough technology for generating the complex radio and microwave pulses that underpin the revolution in quantum computing and quantum sensing. Quantum technologies are rapidly emerging from laboratory to real-world applications including neural imaging, defence surveillance, and mining exploration, but further advances require increased precision and flexibility in controlling the quantum states at the heart of these new capabilities. Our innovative and more flexible approach to signal generation requires a fraction of the size, weight, power and cost of conventional approaches, enabling the translation of quantum technology to commercial practicality.Read moreRead less
Rainbows on demand: coherent comb sources on a photonic chip. This project aims to create photonic circuit technologies that will generate hundreds of coherent laser lines from a single chip. The emerging industrially scalable silicon nitride on thin-film lithium niobate platform will be advanced to create resonant modulators and nonlinear waveguides with unprecedented efficiency and innovative monitoring and control techniques. When combined, these components will enable highly flexible and rob ....Rainbows on demand: coherent comb sources on a photonic chip. This project aims to create photonic circuit technologies that will generate hundreds of coherent laser lines from a single chip. The emerging industrially scalable silicon nitride on thin-film lithium niobate platform will be advanced to create resonant modulators and nonlinear waveguides with unprecedented efficiency and innovative monitoring and control techniques. When combined, these components will enable highly flexible and robust systems for generating a comb of coherent laser lines. These photonic chip comb sources will be inexpensive, compact and energy efficient with transformative impact in spectroscopy, microscopy, precision measurement, quantum computing and ultra-fast optical fibre communications.Read moreRead less
ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reac ....ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reactions and how higher brain function emerges from networks of neurons. By building a diverse, multidisciplinary, and industry-engaged ecosystem, the Centre means to develop our future leaders at the interface of quantum science and biology and drive Australian innovation across manufacturing, energy, agriculture, health, and national security.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100002
Funder
Australian Research Council
Funding Amount
$3,000,000.00
Summary
Australian Partnership in Advanced LIGO+: continuation. The aim of this project is, in collaboration with the USA and UK, to complete the installation and commissioning of the Advanced LIGO+ facilities in the USA in order to bring them to design sensitivity. These facilities expect to increase the event rate of gravitational wave signals by a factor of 125. This should lead to daily detections and the observation of new sources of gravitational waves. Given that only 5% of the universe is detect ....Australian Partnership in Advanced LIGO+: continuation. The aim of this project is, in collaboration with the USA and UK, to complete the installation and commissioning of the Advanced LIGO+ facilities in the USA in order to bring them to design sensitivity. These facilities expect to increase the event rate of gravitational wave signals by a factor of 125. This should lead to daily detections and the observation of new sources of gravitational waves. Given that only 5% of the universe is detectable by telescopes, the impact of gravitational wave detections on our understanding of the universe is inestimable. Australian partnership intends to enable our physicists and astronomers to be at the vanguard of this brand new field and inspire a new generation to study the physical sciences.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100964
Funder
Australian Research Council
Funding Amount
$456,354.00
Summary
Precision Rulers for the Visible - Chip Scale Optical Frequency Combs. This project aims to create a photonic chip technology that generates hundreds of coherent laser lines in the visible spectrum from a single chip for accurate sensing, imaging unknown objects and measuring gas emissions. The project expects to introduce this new capability in the current photonic chip technology, which currently only operates with infrared light. The expected outcomes are inexpensive, stable and energy-effici ....Precision Rulers for the Visible - Chip Scale Optical Frequency Combs. This project aims to create a photonic chip technology that generates hundreds of coherent laser lines in the visible spectrum from a single chip for accurate sensing, imaging unknown objects and measuring gas emissions. The project expects to introduce this new capability in the current photonic chip technology, which currently only operates with infrared light. The expected outcomes are inexpensive, stable and energy-efficient devices the size of a fingernail that will enable measurements with unprecedented accuracies. This should allow these devices to be mounted on drones, satellites, and robots, making them attractive for defence, information security, imaging, autonomous vehicle, and sensing applications.Read moreRead less
Harnessing sperm dynamics in microfluidic sorting technologies. Mammalian reproductive tract is a complex microenvironment that has evolved to select the best sperm for fertilisation using a range of rheological, biochemical and geometrical cues. The project aims to engineer the first multiplexed platform, informed by the natural process, for fully automated and rapid selection of sperm based on all key selection criteria: morphology, swimming behaviour, and DNA integrity. The expected outcome i ....Harnessing sperm dynamics in microfluidic sorting technologies. Mammalian reproductive tract is a complex microenvironment that has evolved to select the best sperm for fertilisation using a range of rheological, biochemical and geometrical cues. The project aims to engineer the first multiplexed platform, informed by the natural process, for fully automated and rapid selection of sperm based on all key selection criteria: morphology, swimming behaviour, and DNA integrity. The expected outcome is the next generation technology for sperm sorting and analysis. This should provide significant benefits, such as new biophysical insights into mammalian reproduction, with potential for future improvement of assisted reproduction technologies – a field in which Australia has a world leading history.Read moreRead less
Parallel Lines: Ultra-dense optical systems for extreme data-rates. The project aims to explore methods to significantly expand global internet data rates, by using emerging ultra-dense optical technologies. The project plans to discover how novel existing and emerging tiny photonic chip devices may enable the use of new, unused optical spectral bands, and then enable 1000s of channels to be supported by exploiting newly available parallelism in both wavelength and space. Success in the project ....Parallel Lines: Ultra-dense optical systems for extreme data-rates. The project aims to explore methods to significantly expand global internet data rates, by using emerging ultra-dense optical technologies. The project plans to discover how novel existing and emerging tiny photonic chip devices may enable the use of new, unused optical spectral bands, and then enable 1000s of channels to be supported by exploiting newly available parallelism in both wavelength and space. Success in the project aims may enable speeds of up to 100 times greater than achievable today, in a variety of fibre optic systems. Connectivity is key to our society, so benefits may arise in both future-proofing key Australian data infrastructure, and in providing a roadmap to support exponential capacity growth over the coming decades.Read moreRead less
New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordi ....New biosensing strategies based on bipolar electrochemiluminescence. Chemical analysis is a vital activity in our society, which is to a large extent confined to scientific laboratories and carried out with complex instrumentation. The breakthrough technology envisioned in this proposal will pave the way for simple, low-cost tests which can be used by non-scientists. The development of small, portable sensors for applications ranging from pollution monitoring to health testing, will enable ordinary people to gain knowledge about the concentrations of molecular compounds in their environments and in themselves. This will stimulate economic and social benefits related to environmental testing and early disease diagnosis and generate new commercial opportunities for the Australian biotechnology industry.Read moreRead less