Discovery Early Career Researcher Award - Grant ID: DE230101542
Funder
Australian Research Council
Funding Amount
$450,154.00
Summary
Impact of humoral immunity on nanoparticle–biological interactions. This project aims to improve the biological applications of nanomaterials by understanding their fundamental interactions with proteins and cells in relevant biological environments. This will create new knowledge on how humoral (antibody-mediated) immunity affects nanomaterials using cutting-edge immunoassays, bio–nano characterisation techniques, and bioinformatics. Expected outcomes of the project include an understanding of ....Impact of humoral immunity on nanoparticle–biological interactions. This project aims to improve the biological applications of nanomaterials by understanding their fundamental interactions with proteins and cells in relevant biological environments. This will create new knowledge on how humoral (antibody-mediated) immunity affects nanomaterials using cutting-edge immunoassays, bio–nano characterisation techniques, and bioinformatics. Expected outcomes of the project include an understanding of how specific antibodies modulate the protein coatings on nanomaterials, which will shed light on how immune cells interact with nanomaterials. This will lead to design principles for nanomaterial properties to improve their effectiveness in delivering drugs and gene therapies.Read moreRead less
Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal ....Engineering nanoscale tools for cellular interrogation. The aim is to address fundamental hurdles to engineering seamless nanobiointerfaces between electroactive nanoscale tools and living cells. This is expected to allow efficient delivery of many bioactive cargo types into cells, intracellular sampling of cytosol contents, and probing of action potential, all at the cell—material interface. New, powerful, electroactive nanoscale tools that deliver precise spatio-temporal resolution and minimal invasiveness and perturbation are likely to transform ex-vivo cellular processes. The intended outcomes are crucial for maximising precision in engineering and implementing of ex-vivo cellular processes. Fundamental advances in knowledge may eventually be a platform for developing cell-based therapies.
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Engineering Functional Antimicrobial Polypeptide Surfaces. Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims ....Engineering Functional Antimicrobial Polypeptide Surfaces. Antimicrobial coatings are vital in preventing bacterial contamination but a versatile solution does not exist. Structurally nanoengineered antimicrobial peptide polymers (SNAPPs) were recently developed to fight multidrug-resistant bacteria. To expand their application into antimicrobial coatings across a range of surfaces, a simple and universal coating strategy is needed. By developing phenolic-functionalised SNAPPs, this project aims to exploit the adhesive nature of metal–phenolic materials to rapidly coat diverse surfaces, including stainless steel and textiles. The expected outcome is the generation of antimicrobial polypeptide surfaces, which will have benefits in food safety, medical implant technology and advanced textiles.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230101371
Funder
Australian Research Council
Funding Amount
$459,592.00
Summary
Boron nitride nanosheets for low energy consumption self-cooling devices. This project aims to investigate the thermal transport mechanism of strained two-dimensional materials for self-cooling thermal management. It expects to generate new knowledge about their unique thermal properties, guiding the use of waste heat generated in electronics for self-cooling. Expected outcomes include a novel energy-effective thermal management strategy and enhanced capacity to engineer thermal transport in two ....Boron nitride nanosheets for low energy consumption self-cooling devices. This project aims to investigate the thermal transport mechanism of strained two-dimensional materials for self-cooling thermal management. It expects to generate new knowledge about their unique thermal properties, guiding the use of waste heat generated in electronics for self-cooling. Expected outcomes include a novel energy-effective thermal management strategy and enhanced capacity to engineer thermal transport in two-dimensional materials that will be deployed in miniaturised and high-density electronics to overcome overheating problems. This will provide significant benefits to the economy and the environment, such as reduced cost, energy consumption and CO2 emissions in thermal management technologies. Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH220100002
Funder
Australian Research Council
Funding Amount
$4,999,700.00
Summary
ARC Research Hub for Fire Resilience Infrastructure, Assets and Safety Advancements (FRIASA) in Urban, Resources, Energy and Renewables Sectors . This Hub aims to develop, manufacture and deploy next generation technologies and solutions that will protect Australia’s critical infrastructure and assets against major natural and man-made fires. The Hub expects to position Australia as a powerhouse of fire readiness by developing end-to-end integrated systems of advanced engineering and digital te ....ARC Research Hub for Fire Resilience Infrastructure, Assets and Safety Advancements (FRIASA) in Urban, Resources, Energy and Renewables Sectors . This Hub aims to develop, manufacture and deploy next generation technologies and solutions that will protect Australia’s critical infrastructure and assets against major natural and man-made fires. The Hub expects to position Australia as a powerhouse of fire readiness by developing end-to-end integrated systems of advanced engineering and digital technologies which will allow industry to improve fire safety training and operations with significant benefits. Expected outcomes include advanced manufacturing capacity for fire resilience and sustainable products, strategic partnerships and commercialisation pathways and opportunities by translating R&D into economic benefits such as jobs and new exports for local and international markets.Read moreRead less
Nanobionic sensors for Real-Time Plant Health Monitoring. This project aims to develop nanosensors to detect and monitor plant health in real-time by measuring stress molecules. The project will create new knowledge on functional materials with unique optical, electronic and thermal properties as well as their bio-nano interactions with plants. The expected outcomes of the project will provide insight into 1) how localised nanosensors target organelles in living plants to 2) generate signals tha ....Nanobionic sensors for Real-Time Plant Health Monitoring. This project aims to develop nanosensors to detect and monitor plant health in real-time by measuring stress molecules. The project will create new knowledge on functional materials with unique optical, electronic and thermal properties as well as their bio-nano interactions with plants. The expected outcomes of the project will provide insight into 1) how localised nanosensors target organelles in living plants to 2) generate signals that can be picked up by portable devices to 3) report on plant health. Functional nanosensors will enable smart farming, precision agriculture and contribute to future agronomic research, further strengthening Australia’s position as an international leader in nanobiotechnology.Read moreRead less
Design of 2D Soft Plasmonic Photocatalysts for Artificial Leaves. The project aims to fabricate 2D soft plasmonic photocatalysts with leaf-like structures and functions for solar-to chemical energy conversions. The proposed 2D photocatalysts expect to change the traditional way of designing artificial photocatalysts. Expected outcomes of this project include fabrication of 2D soft plasmonic photocatalyst with large-area, ultrathin thickness, and high flexibility, understanding their plasmon-enha ....Design of 2D Soft Plasmonic Photocatalysts for Artificial Leaves. The project aims to fabricate 2D soft plasmonic photocatalysts with leaf-like structures and functions for solar-to chemical energy conversions. The proposed 2D photocatalysts expect to change the traditional way of designing artificial photocatalysts. Expected outcomes of this project include fabrication of 2D soft plasmonic photocatalyst with large-area, ultrathin thickness, and high flexibility, understanding their plasmon-enhanced photocatalysis mechanisms, and construction of artificial leaves to perform the solar-to-chemical conversions, which can provide significant benefits, such as creating new-generation of soft energy devices and advancing Australian expertise in photochemistry, self-assembly, and functional nanomaterials.Read moreRead less
Next generation closed-loop brain-machine interfaces . Our partners Carbon Cybernetics have developed high-density neural recording and stimulation arrays that employ fine carbon fibres as the electrode material. The aim of the project is to exploit the properties of these materials to develop miniature implantable devices that are able to achieve long-term, closed-loop, high-resolution recording and stimulation within the brain. We aim to demonstrate an advanced algorithm for control of neural ....Next generation closed-loop brain-machine interfaces . Our partners Carbon Cybernetics have developed high-density neural recording and stimulation arrays that employ fine carbon fibres as the electrode material. The aim of the project is to exploit the properties of these materials to develop miniature implantable devices that are able to achieve long-term, closed-loop, high-resolution recording and stimulation within the brain. We aim to demonstrate an advanced algorithm for control of neural function. Devices that interface directly with the brain are increasingly important in neuroscience to understand how the brain processes information and creates memories and self awareness and are critically important to the development of technologies that interface electronics with the human body. Read moreRead less
How do vortices live in spatio-temporally complex flows? The project aims to understand the fundamental mechanism of vortices occurring in flows involving spatio-temporal complexity, by using the combination of dynamical systems theory and asymptotic analysis. This innovative combined mathematical analysis will be coupled with sophisticated computations to be enabled by the international interdisciplinary collaboration between the Mathematics and Engineering at Australia and Japan. The expected ....How do vortices live in spatio-temporally complex flows? The project aims to understand the fundamental mechanism of vortices occurring in flows involving spatio-temporal complexity, by using the combination of dynamical systems theory and asymptotic analysis. This innovative combined mathematical analysis will be coupled with sophisticated computations to be enabled by the international interdisciplinary collaboration between the Mathematics and Engineering at Australia and Japan. The expected outcomes are breakthroughs in the fundamental understanding of turbulence. This should lead to significant insight into better turbulent modellings used in, for example, wide range of engineering, physiological and geophysical flows.Read moreRead less
Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment an ....Replicating the cartilage micromechanical environment. Through a novel, image-guided mechanical evaluation of cell- and tissue-level remodelling, this project aims to unlock new insights into the complex mechanical microenvironment of cartilage and directly influence new strategies in tissue engineering. The research will reveal contributions of cells and extracellular matrix components to mechanical integrity over time. It will build a world-first strain map of the cartilage microenvironment and quantification of dynamic structural remodelling that occurs, providing key targets to improve tissue engineering strategies. The project will also drive innovation in micromechanical testing technology, deliver functional solutions in mechanobiology and advance materials for biological integration.Read moreRead less