Discovery Early Career Researcher Award - Grant ID: DE240100128
Funder
Australian Research Council
Funding Amount
$450,000.00
Summary
Engineering microenvironments to regulate osteocyte 3D networks in vitro. Most knowledge of bone is based on only a fraction of cells found in bone because the majority of cells in our bones (called osteocyte cell networks) cannot easily be grown or studied outside the body. This results in the inability to understand how the bone organ functions. Using bioinspired engineering, this project will use advanced biomaterials to biofabricate, for the first time, osteocyte cell networks in vitro. By u ....Engineering microenvironments to regulate osteocyte 3D networks in vitro. Most knowledge of bone is based on only a fraction of cells found in bone because the majority of cells in our bones (called osteocyte cell networks) cannot easily be grown or studied outside the body. This results in the inability to understand how the bone organ functions. Using bioinspired engineering, this project will use advanced biomaterials to biofabricate, for the first time, osteocyte cell networks in vitro. By unravelling how they are formed and controlled by manipulating their microenvironment, we will discover how different types of bones are formed. The benefits will be a valuable tool for the bone research community, allowing unresolved questions to be addressed in the future, such as how bone forms, repairs, and remodels.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100259
Funder
Australian Research Council
Funding Amount
$445,437.00
Summary
Next Generation Mass Spectrometry for Single-Cell Metabolomics. Characterising metabolites at the single cell level will provide valuable insights into the functionality of individual cells and reveal mechanisms that cannot be observed in bulk cell analysis. To address existing challenges in single-cell metabolite analysis, this project aims to develop an ultra-sensitive nanostructure-initiator mass spectrometry (NIMS) platform, which uses an innovative carbon material with a carefully designed ....Next Generation Mass Spectrometry for Single-Cell Metabolomics. Characterising metabolites at the single cell level will provide valuable insights into the functionality of individual cells and reveal mechanisms that cannot be observed in bulk cell analysis. To address existing challenges in single-cell metabolite analysis, this project aims to develop an ultra-sensitive nanostructure-initiator mass spectrometry (NIMS) platform, which uses an innovative carbon material with a carefully designed nanostructure to enhance detection efficiency. Expected outcomes include the development of a revolutionary carbon assisted NIMS platform for single-cell metabolomics analysis, and valuable intellectual property of commercial interest to provide economic benefit to Australia through technology advancement.Read moreRead less
Innovative Stable Free Radical-Substituted Conjugated Electronic Polymers. The project aims to develop an innovative class of stable free radicals side-chain substituted conjugated donor-acceptor electronic polymers with unique polaronic and radical charge transport capabilities. The targeted optoelectronic material class is unique and has not been explored in depth before. The combination of unpaired electrons and delocalized backbone -electrons delivers exciting modes of charge transfer that ....Innovative Stable Free Radical-Substituted Conjugated Electronic Polymers. The project aims to develop an innovative class of stable free radicals side-chain substituted conjugated donor-acceptor electronic polymers with unique polaronic and radical charge transport capabilities. The targeted optoelectronic material class is unique and has not been explored in depth before. The combination of unpaired electrons and delocalized backbone -electrons delivers exciting modes of charge transfer that provide these novel materials with clear potential as electroactive materials with applications in various nanoelectronics devices. Developing a fundamental understanding of charge transport properties and potential device applications will open up a new field of research in advanced optoelectronic technology. Read moreRead less
Industrial Transformation Research Hubs - Grant ID: IH220100002
Funder
Australian Research Council
Funding Amount
$4,999,700.00
Summary
ARC Research Hub for Fire Resilience Infrastructure, Assets and Safety Advancements (FRIASA) in Urban, Resources, Energy and Renewables Sectors . This Hub aims to develop, manufacture and deploy next generation technologies and solutions that will protect Australia’s critical infrastructure and assets against major natural and man-made fires. The Hub expects to position Australia as a powerhouse of fire readiness by developing end-to-end integrated systems of advanced engineering and digital te ....ARC Research Hub for Fire Resilience Infrastructure, Assets and Safety Advancements (FRIASA) in Urban, Resources, Energy and Renewables Sectors . This Hub aims to develop, manufacture and deploy next generation technologies and solutions that will protect Australia’s critical infrastructure and assets against major natural and man-made fires. The Hub expects to position Australia as a powerhouse of fire readiness by developing end-to-end integrated systems of advanced engineering and digital technologies which will allow industry to improve fire safety training and operations with significant benefits. Expected outcomes include advanced manufacturing capacity for fire resilience and sustainable products, strategic partnerships and commercialisation pathways and opportunities by translating R&D into economic benefits such as jobs and new exports for local and international markets.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100236
Funder
Australian Research Council
Funding Amount
$463,583.00
Summary
Designing and fabricating artificial blood cells for global shortages. This project aims to create the first biophysically accurate artificial blood cells through fabrication of novel synthetic particles that mimic the complex layers of red blood cells. Using innovative methods from engineering and biology, this project expects to advance biofabrication techniques for biosynthetic microparticles. Expected outcomes from this project include the development of a portable, cost-effective platform t ....Designing and fabricating artificial blood cells for global shortages. This project aims to create the first biophysically accurate artificial blood cells through fabrication of novel synthetic particles that mimic the complex layers of red blood cells. Using innovative methods from engineering and biology, this project expects to advance biofabrication techniques for biosynthetic microparticles. Expected outcomes from this project include the development of a portable, cost-effective platform technology to immediately advance foundational understanding of cell membrane dynamics, interactions, and integrity. We anticipate that the new bioengineered blood product will provide significant future benefits for blood storage and transfusion, including potentially alleviating global blood shortages.Read moreRead less
Thermal engineering in semiconductor heterojunction for space transducers . Microelectromechanical system (MEMS) transducers, including sensors and actuators, are essential for space applications. However, MEMS transducers have not yet provided compelling performance for the space industry as they typically experience degradation of performance when subjected to elevated temperature and radiation. This research aims to develop an innovative transducer technology that uses a temperature gradient ....Thermal engineering in semiconductor heterojunction for space transducers . Microelectromechanical system (MEMS) transducers, including sensors and actuators, are essential for space applications. However, MEMS transducers have not yet provided compelling performance for the space industry as they typically experience degradation of performance when subjected to elevated temperature and radiation. This research aims to develop an innovative transducer technology that uses a temperature gradient to enhance performance and a radiation-hard material to ensure reliability and longevity. Expected outcomes include improved understanding of transducer performance under temperature gradient, appropriate material selection, and design recommendations for high-performance transducers with applications in space and defence.Read moreRead less
Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this ....Bio-inspired Nanoparticles for Mechano-Regulation of Stem Cell Fate. Mechanical stimulation plays a critical role in regulating stem cell fate. Nanostructure-mediated mechanical cues can precisely stimulate stem cells, but predicting their impact on stem cell differentiation is challenging. This project aims to engineer nanostructures to regulate stem cell fate and gain a fundamental understanding of the mechanical properties that affect cell function. The expected outcomes and benefits of this project include a new fundamental understanding of the effect of mechanical properties on cell function, novel insights into the regulation of stem cell fate, and the development of a new class of roughness-tunable materials suitable for use in tissue engineering and pharmaceutical applications. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE240100408
Funder
Australian Research Council
Funding Amount
$446,411.00
Summary
Advancing bioelectronics with silicon carbide on microfluidics. Flexible bioelectronics is an emerging technology for real-time monitoring of vital signals on skin and in the body. Microfluidics is a technology for fluid handling in microscale. This project aims to develop the first platform technology with both flexible bioelectronics and microfluidics for enhanced sensing, thermal management and actuation. The project is expected to establish new fundamental knowledge in sensitivity boosting m ....Advancing bioelectronics with silicon carbide on microfluidics. Flexible bioelectronics is an emerging technology for real-time monitoring of vital signals on skin and in the body. Microfluidics is a technology for fluid handling in microscale. This project aims to develop the first platform technology with both flexible bioelectronics and microfluidics for enhanced sensing, thermal management and actuation. The project is expected to establish new fundamental knowledge in sensitivity boosting mechanisms with nano-thin semiconducting films, practical prototypes for long-lasting bioelectronics with integrated microfluidics and their large-scale manufacturing processes. Outcomes include step changes in designing innovative wearable and implantable devices and their massive commercialisation opportunities.Read moreRead less
Mathematical and Numerical Models of Piezoelectric Wave Energy Converters. The project will investigate piezoelectric wave energy converters. We will derive the equations of motion in a form suitable for use in marine engineering paradigms using variational methods and then solve these analytically and with smoothed particle hydrodynamics. Using these innovative techniques, this project will generate new knowledge capable of elucidating the multifaceted physical phenomena that occur when comple .... Mathematical and Numerical Models of Piezoelectric Wave Energy Converters. The project will investigate piezoelectric wave energy converters. We will derive the equations of motion in a form suitable for use in marine engineering paradigms using variational methods and then solve these analytically and with smoothed particle hydrodynamics. Using these innovative techniques, this project will generate new knowledge capable of elucidating the multifaceted physical phenomena that occur when complex fluid motion and deformable structures interact. The project outcomes include the development of mathematical and computation methods to handle intricate behaviours of piezoelectric elastic-fluids systems. These groundbreaking methods will allow these wave energy systems to be analysed and their effectiveness assessed.Read moreRead less
Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. T ....Combining biomechanics and movement ecology of kangaroos and relatives. Kangaroos and their relatives are unique in their body form, hopping gait and by the fact that increased speed does not come at an increased energetic cost. This project aims to build 3D musculoskeletal models to understand how muscles and tendons interact, enabling greater distances to be travelled using less energy. Further, it will use animal tracking devices and machine-learning tools to quantify movements in the wild. This framework will provide novel insights into how energetics, morphology, and habitat have shaped the evolution of this unique group. This may open doors to a range of future ecological, physiological, and conservation studies and provide biological inspiration for energetically efficient robotic and assistive devices.Read moreRead less