Versatile dosimetry systems for radiotherapy and industrial applications: novel storage phosphor and associated reader technologies. Radiotherapy is an important procedure in the treatment of cancer, and it is essential that the radiation dosage can be accurately measured. This project will develop technology which will enable us to monitor radiation dosage in real time and very accurately. This will be of importance in medical science and also for industrial applications.
Benchmarking of advanced scattering probes for materials characterisation. The project seeks to establish the accuracy and validity of different methods of nanoscale structure determination. Nanoscale structure is crucial to the properties of many modern materials with diverse applications: e.g. sensors and actuators in cell phones; smart shock absorbers and fuel injectors in cars; memory devices; drug delivery devices.
Discovery Early Career Researcher Award - Grant ID: DE190101397
Funder
Australian Research Council
Funding Amount
$405,000.00
Summary
Superconducting hybrid quantum technologies. This project aims to extend the density and coherence of qubits stored in superconducting-based quantum processors, by exploring the concept of hybrid quantum systems. Quantum computers are expected to impact a diverse range of sectors, from medicine to national security. This project seeks to develop an enabling technology, a memory, for scaling a quantum computer constructed from superconducting circuits, such as those being developed in commercial ....Superconducting hybrid quantum technologies. This project aims to extend the density and coherence of qubits stored in superconducting-based quantum processors, by exploring the concept of hybrid quantum systems. Quantum computers are expected to impact a diverse range of sectors, from medicine to national security. This project seeks to develop an enabling technology, a memory, for scaling a quantum computer constructed from superconducting circuits, such as those being developed in commercial laboratories. Such scaling would improve the capacity of these processors to tackle complex problems. The quantum technology developed in this project will have immediate application in transforming a widely-used technique for studying the nanoscale structure of biomolecules - distance measurements in electron spin resonance spectroscopy.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE130100061
Funder
Australian Research Council
Funding Amount
$710,000.00
Summary
Extending frontiers of structural chemistry and biology through high resolution pulsed Electron Paramagnetic Resonance. Multifrequency high resolution pulsed Electron Paramagnetic Resonance (EPR) instrumentation will provide forefront technologies in identifying, characterising, quantifying and visualising free radicals and metal ions that are involved in fundamental chemical and biological processes in science and nature.
Unravelling the structural complexity of ancient Australian arthropod venoms. Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of ....Unravelling the structural complexity of ancient Australian arthropod venoms. Animal venoms contain a complex mix of molecules that have evolved over millions of years to target various biological processes. Their exquisite specificity and potent activity has made them an attractive source for development as therapeutic drugs with fewer side effects or as environmentally friendly insecticides. This project aims to for the first time explore the three-dimensional structure of all known classes of toxins in the venom of two ancient Australian arthropods (spiders and centipedes). This will provide a comprehensive overview of these venoms and provide opportunities in engineering new classes of venom based drugs and insecticides. Read moreRead less
Locating Atoms by Observing Crystallographic Phase. Atomic structures are determined by measuring how they scatter radiation. However half of the necessary information, the crystallographic phase, cannot be measured from the scattered intensity. For a century the only option has been to deduce the phase via the statistical analysis of thousands of intensity measurements. This project aims to develop a method to determine atomic structures from the direct observation of phase. From a handful of o ....Locating Atoms by Observing Crystallographic Phase. Atomic structures are determined by measuring how they scatter radiation. However half of the necessary information, the crystallographic phase, cannot be measured from the scattered intensity. For a century the only option has been to deduce the phase via the statistical analysis of thousands of intensity measurements. This project aims to develop a method to determine atomic structures from the direct observation of phase. From a handful of observations and no formal measurements, atoms can be located with picometre precision. It is predicted that this method will be direct, rapid and unequivocal, sensitive to light atoms and applicable to nanostructures, which will represent a paradigm shift in crystallography.Read moreRead less
Automated structural analysis of proteins by nuclear magnetic resonance (ASAP-NMR): a leap forward in structural studies of proteins using NMR spectroscopy. Proteins form the machinery that makes life possible, and this research will revolutionise study of their three-dimensional structure by making the process faster and cheaper. This approach will be applied to study proteins isolated from animal venoms in order to identify and develop novel pharmaceuticals and bio-insecticides.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE150100187
Funder
Australian Research Council
Funding Amount
$290,000.00
Summary
SA Facility for High Resolution Imaging and Material Characterization. Facility for high resolution imaging and material characterisation: The aim of this project is to establish a facility that will allow researchers to visualise and analyse structure at nanoscale resolutions. The development of the next generation of opto-electronics, electrochemical and biomedical devices requires tools that can quickly visualise and characterise complex materials at multiscale. The new collaborative nano in ....SA Facility for High Resolution Imaging and Material Characterization. Facility for high resolution imaging and material characterisation: The aim of this project is to establish a facility that will allow researchers to visualise and analyse structure at nanoscale resolutions. The development of the next generation of opto-electronics, electrochemical and biomedical devices requires tools that can quickly visualise and characterise complex materials at multiscale. The new collaborative nano infrared thermal analysis facility is essential to meet the demands of a large number of innovative projects conducted by multidisciplinary consortia of researchers. Located in state-of-the art laboratories and managed as open access resources, the facility will enable and advance research in the areas of energy harvesting, environmental monitoring, biomedical devices, food and pharmaceuticals.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100162
Funder
Australian Research Council
Funding Amount
$300,000.00
Summary
Ultrafast Science Facility: manipulating and probing matter on fs timescales with microscopic resolution. Ultrafast science facility: manipulating and probing matter on femtosecond timescales with microscopic resolution: Knowledge of dynamics that occur on femtosecond timescales is essential for a detailed understanding of many important processes in physics, chemistry and biology. This facility will enable unprecedented insight into the mechanisms driving such processes through complementary ca ....Ultrafast Science Facility: manipulating and probing matter on fs timescales with microscopic resolution. Ultrafast science facility: manipulating and probing matter on femtosecond timescales with microscopic resolution: Knowledge of dynamics that occur on femtosecond timescales is essential for a detailed understanding of many important processes in physics, chemistry and biology. This facility will enable unprecedented insight into the mechanisms driving such processes through complementary capabilities to manipulate and probe matter on femtosecond time scales at microscopic resolution. Such processes include photosynthetic energy transfer, efficient operation of organic electronics, redox reactions in biological systems and the manipulation of material properties by intense femtosecond-laser pulses. The unique capabilities of this facility will also allow the development of novel device structures and the limits of the characterisation techniques to be pushed.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100076
Funder
Australian Research Council
Funding Amount
$155,000.00
Summary
The first Australian high pressure Synchrotron facility for geoscience research. In high-pressure mineral physics and chemistry, mineral properties, stress-strain relationships and processes like partial melting are applied to geophysical research about the deep Earth. This project will provide a large volume, high pressure capability at the Australian Synchrotron which will allow these mineral properties to be measured under conditions which simulate the deep earth.