On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technol ....On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technology is expected to provide new capability in bioanalysis, proteomics and rapid clinical diagnostics. Future benefits may include new commercial fibre based technologies which could be applied within industrial and clinical laboratories within the next ten years.Read moreRead less
Selectivity enhancement in separation science using responsive materials. Increasing public demand for quality products from the chemical, pharmaceutical, biotechnology and food industries requires access to innovative methods of chemical analysis. This project will establish a new class of separation materials of enhanced selectivity and resolving power for the fast, sensitive and reliable analysis of these products.
Carbonaceous adsorbents for ultra-high performance liquid chromatography. This project aims to develop a new generation of mechanically and thermally stable carbon-nanocarbon composite adsorbents for ultra-high-performance liquid chromatography. The structure of adsorbents will be constructed according to advanced core-shell design with non-porous carbon central core and porous shell formed by highly ordered uniform nanocarbon particles. The unique properties of carbon-nanocarbon composite adsor ....Carbonaceous adsorbents for ultra-high performance liquid chromatography. This project aims to develop a new generation of mechanically and thermally stable carbon-nanocarbon composite adsorbents for ultra-high-performance liquid chromatography. The structure of adsorbents will be constructed according to advanced core-shell design with non-porous carbon central core and porous shell formed by highly ordered uniform nanocarbon particles. The unique properties of carbon-nanocarbon composite adsorbents will put liquid chromatography to qualitatively new levels of the separation performance that may open new possibilities for medicine and biodiagnostics. The resulting technology also has a strong potential to be used in other priority areas such as preparation of electrodes and supercapacitors for energy storage devices.Read moreRead less
Resolving dissolved organic matter: new multi-dimensional separation approaches. To fully understand and model global carbon cycles the source, nature and fate of oceanic dissolved organic carbon is an essential element. This project will develop, model and apply new orthogonol and complementary separation science based technologies to further the comprehensive characterisation and understanding of these complex systems.
Lectin based open tubular micro-reactors for probing protein-protein binding. This project seeks to develop non-invasive technology for the measurement and quantitation of lectin-carbohydrate binding events, in the first instance glycopeptides and glycoproteins. The goal is not only to provide accurate protein-protein association and dissociation constant data within the developed system, but to do so within an enclosed micro-fluidic environment, with the added advantages of also providing ‘trap ....Lectin based open tubular micro-reactors for probing protein-protein binding. This project seeks to develop non-invasive technology for the measurement and quantitation of lectin-carbohydrate binding events, in the first instance glycopeptides and glycoproteins. The goal is not only to provide accurate protein-protein association and dissociation constant data within the developed system, but to do so within an enclosed micro-fluidic environment, with the added advantages of also providing ‘trap and release’ extraction capabilities, and being easily coupled to both chromatographic and mass spectrometry systems. Read moreRead less
A field-portable comprehensive multidimensional gas chromatograph. This project represents an innovative new direction for chemical analysis of environmental contaminants with further case studies planned in a number of diverse application areas. State-of-the-art field-portable instrumentation will be developed to bridge the capability gap for performing in-field analysis of highly complex samples.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100018
Funder
Australian Research Council
Funding Amount
$630,000.00
Summary
Purchase of a high resolution Nuclear Magnetic Resonance spectrometer with liquid chromatography module. A high resolution Nuclear Magnetic Resonance spectrometer and liquids separation module will support Tasmanian research of international significance across the biological and medical sciences, chemistry and Tasmanian industries including profiling studies in human health, plant biology, molecular basis of disease and complex mixture analysis.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE180100059
Funder
Australian Research Council
Funding Amount
$350,790.00
Summary
Advanced high resolution biomolecular analysis facility for Tasmania. This project aims to establish an advanced, multi-purpose mass spectrometry platform for high-throughput and targeted biomolecular analysis, including proteomics and metabolomics. The purpose of the project is to provide a centralised state-of-the-art facility that supports research programs in plant science, agricultural research, food safety, animal and human health research and separation science. Potential benefits from th ....Advanced high resolution biomolecular analysis facility for Tasmania. This project aims to establish an advanced, multi-purpose mass spectrometry platform for high-throughput and targeted biomolecular analysis, including proteomics and metabolomics. The purpose of the project is to provide a centralised state-of-the-art facility that supports research programs in plant science, agricultural research, food safety, animal and human health research and separation science. Potential benefits from the project include increased agricultural productivity and food security, improved knowledge of age and injury-related changes in neurophysiology, helping to prevent the extinction of iconic Tasmanian wildlife and the development of advanced micro-electroseparation technologies.Read moreRead less
Polymer nanoparticles and their assembled supracolloidal monolithic structures for applications in separation science. This project will generate new polymeric materials that will improve the analysis of complex samples. This will be applied in a wide range of areas of national importance including: pharmaceutical analysis and drug discovery; environmental, clinical and forensic analysis; and energy generation and foods.
Discovery Early Career Researcher Award - Grant ID: DE150100263
Funder
Australian Research Council
Funding Amount
$373,536.00
Summary
Halogen Bonding for Assembly and Separation in Solution. The properties of substances we experience in our daily lives owe much to very weak interactions taking place between molecules. Consider a cup of coffee: very weak interactions hold the water together as a liquid, and result in the biological action of caffeine within the body. The project aims to develop new materials based on an underexplored class of weak interactions known as halogen bonds. These interactions will be used to assemble ....Halogen Bonding for Assembly and Separation in Solution. The properties of substances we experience in our daily lives owe much to very weak interactions taking place between molecules. Consider a cup of coffee: very weak interactions hold the water together as a liquid, and result in the biological action of caffeine within the body. The project aims to develop new materials based on an underexplored class of weak interactions known as halogen bonds. These interactions will be used to assemble large molecules in solution, probe the presence of pollutants in water, and to separate active and inactive forms of pharmaceuticals. The development of health and environmental applications in the course of this project aim to significantly enhance our fundamental understanding of these weak interactions.Read moreRead less