Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability t ....Micro-electrofluidic platforms for monitoring 3D human biological models. The ability to study living cells and human biological models (cell cultures) delivers greater understanding of basic biological function and response to applied (bio)chemical stimuli. Creating the physical environments to sustain biological models, and mimic natural conditions and fluidic pathways, is immensely challenging, yet essential to deliver meaningful observational data. This project will deliver this capability through the convergence of expertise and innovation in analytical chemistry, materials science and cellular biology, ultilising the latest technology and understanding of 3D micro/electrofluidics, to enable the study and stimulation of advanced biological models, sustained within precisely controlled 3D micro-environments.Read moreRead less
Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected ....Understanding the mechanisms underpinning complex sociality. This project aims to investigate the mechanisms underlying the formation of complex social systems in vertebrates. Our understanding of these mechanisms is strongly biased towards a few model systems. We have identified a novel Australian model system with a wide range of sociality for this purpose. This project expects to generate new knowledge on how the social environment interacts with the brain during social organisation. Expected outcomes include the refinement of social theory and capacity building via international collaboration and postgraduate training. This work will provide significant benefits by increasing our understanding of how the brain and social environment interact to moderate aggression and enhance social associations.Read moreRead less
On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technol ....On-fibre separation science with ambient ionisation mass spectrometry. This project aims to combine fibre-based electrofluidics and ambient ionisation mass spectrometry. Fibre-based electrophoresis is a separation technology which is cheaper, simpler and faster than pre-MS analyses. This project will use the fibre simultaneously as the ionisation platform for ambient mass spectrometry, combining the processes of separation and ionisation in a portable and flexible platform. The developed technology is expected to provide new capability in bioanalysis, proteomics and rapid clinical diagnostics. Future benefits may include new commercial fibre based technologies which could be applied within industrial and clinical laboratories within the next ten years.Read moreRead less
An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will r ....An efficient approach to the computation of bacterial evolutionary distance. This project aims to apply advanced mathematical tools to improve our understanding of bacterial evolution. Bacteria account for as much total Earth biomass as all plant species put together, and have an unparalleled ability to evolve quickly and adapt to changing environments. Unfortunately, the existing mathematical models used to model bacterial evolution are generally computationally intractable. This project will rectify this situation by using representation theory to transform combinatorial group theory into linear algebra, allowing for the application of advanced methods of numeric approximation. This will provide a better understanding of how bacteria evolve and improve our ability to manage their impact.Read moreRead less
Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the ....Lags and legacies: antecedent effects on grassland biomass response to carbon dioxide. This project aims to assess how past conditions influence grassland responses to the rising atmospheric concentration of carbon dioxide. High CO2 concentrations should stimulate productivity but in grasslands this is rarely realised because other, mostly unknown, factors constrain the response. By synthesising data from past experiments, this project aims to determine exactly why grasslands fail to realise the full productivity benefits of increased CO2 and when this will happen. This should improve predictions of carbon exchange and indicating the best direction for climate change adaptation measures.Read moreRead less
Changes in the ocean's biological pump: innovative models and diagnostics. This Project aims to quantify how the ocean’s biological pump, which exports newly formed organic matter into the ocean interior, responds to environmental change. The biological pump is a key control on the global carbon and oxygen cycles, and hence on the viability of marine life. New, efficient numerical models will be developed and analysed with highly innovative mathematical methods. Expected outcomes are optimised .... Changes in the ocean's biological pump: innovative models and diagnostics. This Project aims to quantify how the ocean’s biological pump, which exports newly formed organic matter into the ocean interior, responds to environmental change. The biological pump is a key control on the global carbon and oxygen cycles, and hence on the viability of marine life. New, efficient numerical models will be developed and analysed with highly innovative mathematical methods. Expected outcomes are optimised predictive models and a new understanding of the possible future evolutions of the ocean carbon cycle, acidification, and oxygenation. This should provide significant benefits such as predictions of future ocean health, identification of processes that are sensitive to change, and strategies for marine resource management.Read moreRead less
Improving the diagnosticity of eyewitness memory choices. Eyewitness identification error is common and costly. This project aims to improve the quality of information provided by eyewitnesses, and the ability of police officers and triers of fact (e.g., juries, judges) to evaluate this information. Laboratory investigations will determine how best to test memory and confidence to achieve this aim. A new class of cognitive models will provide a unified account of response accuracy, response time ....Improving the diagnosticity of eyewitness memory choices. Eyewitness identification error is common and costly. This project aims to improve the quality of information provided by eyewitnesses, and the ability of police officers and triers of fact (e.g., juries, judges) to evaluate this information. Laboratory investigations will determine how best to test memory and confidence to achieve this aim. A new class of cognitive models will provide a unified account of response accuracy, response time, and confidence, suitable for application to computerized testing scenarios. The models and testing methods validated in the laboratory will be refined for application in eyewitness memory settings, facilitating better evaluation of identification evidence, and potentially reducing wrongful convictions.Read moreRead less
Eruption and disruption: how Earth’s deep interior and surface communicate. Massive volcanic eruptions are a fundamental part of the Earth System, responsible for globally disruptive events, from airspace disturbance, to extinction of the dinosaurs. This project will reveal relationships between hot, deep sources of volcanic material, and the tectonic processes at the Earth's surface. Expected outcomes of this project include assembling an unprecedented set of new observations from underwater vo ....Eruption and disruption: how Earth’s deep interior and surface communicate. Massive volcanic eruptions are a fundamental part of the Earth System, responsible for globally disruptive events, from airspace disturbance, to extinction of the dinosaurs. This project will reveal relationships between hot, deep sources of volcanic material, and the tectonic processes at the Earth's surface. Expected outcomes of this project include assembling an unprecedented set of new observations from underwater volcanoes offshore Eastern Australia, and the development of innovative geodynamic models of how the deep Earth interacts with the surface to form these volcanoes. This will provide significant benefits by advancing our understanding of the deep Earth, and its impact on Earth’s surface, natural hazards, and mineral systems.Read moreRead less
Beyond Extinction: Reconstructing the Thylacine (Tasmanian Tiger) Archive. This project aims to tell a global story about extinction as a human problem, by reconstructing the individual biographies of a selection of thylacine (Tasmanian tiger) specimens. Through transforming these specimens into grieveable lives the project expects to facilitate scholarly and public engagement with the cultural history of extinction, advancing the foundation for a sustainable and informed response that may help ....Beyond Extinction: Reconstructing the Thylacine (Tasmanian Tiger) Archive. This project aims to tell a global story about extinction as a human problem, by reconstructing the individual biographies of a selection of thylacine (Tasmanian tiger) specimens. Through transforming these specimens into grieveable lives the project expects to facilitate scholarly and public engagement with the cultural history of extinction, advancing the foundation for a sustainable and informed response that may help prevent further extinctions. In bringing together the zoo and the museum as key sites for the development of public environmental sentiment, this project has the potential to generate new and globally-relevant resources for engaging with conservation and extinction, through these institutions and beyond.Read moreRead less
Global patterns of mammalian biodiversity loss over the last 50,000 years. Wild mammals have experienced major population losses and extinctions in recent centuries, but their communities had already suffered from widespread losses during the Pleistocene. Existing literature has focused on documenting individual extinctions or continental-scale patterns. This project aims to show how biodiversity loss played out at the local scale around the world. It will use palaeontological and zooarchaeologi ....Global patterns of mammalian biodiversity loss over the last 50,000 years. Wild mammals have experienced major population losses and extinctions in recent centuries, but their communities had already suffered from widespread losses during the Pleistocene. Existing literature has focused on documenting individual extinctions or continental-scale patterns. This project aims to show how biodiversity loss played out at the local scale around the world. It will use palaeontological and zooarchaeological data to show how losses varied in space, how population sizes changed, and how species attributes such as rarity and body size related to loss. The world of mammals has become more homogeneous as biodiversity has declined. The challenge is to show how that happened across space and time.
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