Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
On-Chip Detection and Molecular Fingerprinting of Emerging Toxicants. The project aims to address key questions about the development and integration of advanced materials and functional molecules into cutting-edge analytical tools for screening emerging environmental pollutants. This is expected to generate fundamental and applied knowledge in analytical chemistry, using an interdisciplinary approach to engineer materials with precisely tailored properties for ultra-sensitive and selective dete ....On-Chip Detection and Molecular Fingerprinting of Emerging Toxicants. The project aims to address key questions about the development and integration of advanced materials and functional molecules into cutting-edge analytical tools for screening emerging environmental pollutants. This is expected to generate fundamental and applied knowledge in analytical chemistry, using an interdisciplinary approach to engineer materials with precisely tailored properties for ultra-sensitive and selective detection of extremely persistent toxicants in water. Anticipated outcomes are optical materials and functional molecules, integrated into lab-on-a-chip platforms with advanced features for real-life environmental applications – with significant benefits for addressing major environmental and health treats to our society.Read moreRead less
An account of wetting phenomena on nano-engineered surfaces. This project aims to provide researchers and industry with a toolbox to predict wetting behaviour on surfaces with nanoscale topography. A combined experimental and numerical study will lead to the discovery of the mechanisms by which topographical and chemical properties of the surface trigger the formation of nanostructure-induced air pockets and how these phenomena determine surface wettability. This will provide significant benefi ....An account of wetting phenomena on nano-engineered surfaces. This project aims to provide researchers and industry with a toolbox to predict wetting behaviour on surfaces with nanoscale topography. A combined experimental and numerical study will lead to the discovery of the mechanisms by which topographical and chemical properties of the surface trigger the formation of nanostructure-induced air pockets and how these phenomena determine surface wettability. This will provide significant benefits, as the predictive surface-wettability model will enhance controllability and productivity of diverse manufacturing processes and lead to new applications, high-value products and economic benefits in mining, energy, electronics, biomedicine and other fields.Read moreRead less
Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a vi ....Closing the loop between salience and brain activity. This project aims to understand how animals exposed to an abundance of highly complex information decide what to attend to, that is, how they determine visual saliency. The project will approach this question by systematically tracking visual decision-making in the smallest animal brains, in closed-loop virtual reality environment. This approach will uncover basic working principles applicable to any system that needs to pay attention in a visually cluttered world, from insects to humans or autonomous vehicles.Read moreRead less
Special Research Initiatives - Grant ID: SR120200004
Funder
Australian Research Council
Funding Amount
$30,000,000.00
Summary
Australian Synchrotron Access Program. The Australian Synchrotron epitomises scientific research excellence in Australian and New Zealand. Its impact spans nearly every research sector. This proposal brings together over 30 Australian universities working together to ensure that world-class peer-reviewed science continues to be performed at the Australian Synchrotron.
Towards knowledge discovery from imperfect and evolving data. Information extraction from data is critical, both to analyse and protect consumer data. However, many learning techniques are developed using perfect, static datasets, quite different to messy, ever-changing real-world data. This project aims to develop data analytics techniques that can extract accurate information in complex structures from imperfect/incomplete data that changes over time. Expected outcomes are a prototype tool, te ....Towards knowledge discovery from imperfect and evolving data. Information extraction from data is critical, both to analyse and protect consumer data. However, many learning techniques are developed using perfect, static datasets, quite different to messy, ever-changing real-world data. This project aims to develop data analytics techniques that can extract accurate information in complex structures from imperfect/incomplete data that changes over time. Expected outcomes are a prototype tool, tested on real datasets, that combines new techniques in data modelling, algorithm development, and system design. Likely benefits are enhanced Australia's competence in data science through student training and new, robust data tools relevant to critical sectors such as cybersecurity, healthcare, and defence.Read moreRead less
Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipi ....Precision-engineered hybrid core-shell materials . This project aims to develop new platform technologies for making nanostructured hybrid core-shell materials with exceptionally high drug loading and programmed release. Building on this research team's recent breakthrough in the precision engineering of core-shell materials, this research will revolutionise current approaches for making drug-loaded polymer and inorganic particles. Significant outcomes will include a novel sequential nanoprecipitation platform technology for making drug-core polymer-shell nanoparticles, and a new bio-inspired approach for making hybrid drug-core silica-shell nanocomposites, and new materials for applications in programmed release and delivery systems.Read moreRead less
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
Special Research Initiatives - Grant ID: SR120300015
Funder
Australian Research Council
Funding Amount
$16,000,000.00
Summary
The Science of Learning Research Centre. In this innovative new Centre, researchers in education, neuroscience and cognitive psychology will work together with teachers to understand the learning process. This collaboration will establish new criteria to assess the impact of different types of learning and strategies to inform teaching practices of benefit to all Australians.