Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new k ....Laser-free on-chip super-resolution microscopy. The project aims to develop a compact, cost-effective on-chip super-resolution microscope through an innovative combination of imaging algorithms, optics and integrated photonics. This project addresses limitations in imaging algorithms that increase laser system complexity and constrain imaging speed and applications, as well as nanostructure fabrication issues. Expected outcomes include the discovery of emitter self-interference microscopy, new knowledge in imaging, photonics and biophysics, the world’s fastest super-resolution technology, compact on-chip nanoscopy that can be added to existing technology and proof of concept in three areas. Benefits are anticipated in commercialisation, improved photonics devices and usage in biophysics.Read moreRead less
ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to unde ....ARC Centre of Excellence for Nanoscale BioPhotonics. The CNBP brings together physicists, chemists and biologists focused on a grand challenge controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. This will allow biological scientists to understand how single cells react to and communicate with their surroundings. This science will underpin a new generation of devices capable of probing the response of cells within individuals to environmental conditions or treatment, creating innovative and powerful new sensing platforms.Read moreRead less
Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most importa ....Integrin Activation by Fluid Flow Disturbance: Mechanobiology Approaches. Understanding how cells can sense and respond to mechanical environment such as dynamic blood flow represents a fundamental question in the emerging field of mechanobiology. This project develops new biomechanical engineering approaches to determine the critical interrelationships among fluid flow disturbance, platelet clotting and the mechano-sensitive signal transduction mechanisms of integrin receptor – the most important mechano-sensor implicated in cell adhesion, migration, growth and survival. Specifically, it integrates nationally unique cutting-edge techniques including single-molecule force probe, microparticle image velocimetry, microfluidics and molecular dynamics simulation, super resolution and 3D volumetric imaging modalities.Read moreRead less
Formation and manipulation of ferroelectric domains with ultrafast light. This project aims to study the fundamental processes governing interaction of ultrafast light pulses with an important class of ferroelectric materials. In particular, it will investigate the physics of light-induced ferroelectric domain reversal in various types of ferroelectrics. Project outcomes will lead to the development of a novel, ultrafast laser domain patterning technique for application in nonlinear photonics, o ....Formation and manipulation of ferroelectric domains with ultrafast light. This project aims to study the fundamental processes governing interaction of ultrafast light pulses with an important class of ferroelectric materials. In particular, it will investigate the physics of light-induced ferroelectric domain reversal in various types of ferroelectrics. Project outcomes will lead to the development of a novel, ultrafast laser domain patterning technique for application in nonlinear photonics, optical memories, and photovoltaics. This technique will be employed to create the first example of three-dimensional domain patterns for versatile wave interactions. This project expects to expand Australia's knowledge in ultrafast laser engineering of materials and contribute towards its rapid uptake by industries, with great potential for commercialisation.Read moreRead less
Analysis of asteroid samples returned by Hayabusa 2 and Osiris-REx . This year sees the highly anticipated return of the Hayabusa2 spacecraft to Woomera carrying samples of the asteroid Ryugu. This is only the fifth extraterrestrial sample return mission in history. The research team has been invited to participate in the preliminary examination which will take place in Japan in early 2021. The investigators have developed unique analytical skills that allow measurement of small amounts of rock ....Analysis of asteroid samples returned by Hayabusa 2 and Osiris-REx . This year sees the highly anticipated return of the Hayabusa2 spacecraft to Woomera carrying samples of the asteroid Ryugu. This is only the fifth extraterrestrial sample return mission in history. The research team has been invited to participate in the preliminary examination which will take place in Japan in early 2021. The investigators have developed unique analytical skills that allow measurement of small amounts of rock for oxygen isotope compositions at unprecedented precision. This project aims to characterise a suite of carbonaceous chondrites, which appear to be the best match to Ryugu, and therefore will provide the exemplar data to understand the provenance of Ryugu, and place it in the context of solar system materials.
Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160100843
Funder
Australian Research Council
Funding Amount
$330,000.00
Summary
Regulating gene delivery with light. This project seeks to deliver the capacity to remotely deliver molecules into specific cells without the need for invasive or viral procedures. Individual genetic predisposition to disease forms a key part of personalised medicine that requires the accurate delivery of drugs or genes. This project aims to develop a new multimodality microscopy that can investigate and optimise light delivery of macromolecules into living cells at high specificity and across a ....Regulating gene delivery with light. This project seeks to deliver the capacity to remotely deliver molecules into specific cells without the need for invasive or viral procedures. Individual genetic predisposition to disease forms a key part of personalised medicine that requires the accurate delivery of drugs or genes. This project aims to develop a new multimodality microscopy that can investigate and optimise light delivery of macromolecules into living cells at high specificity and across a multitude of cells. The expected outcome of this project is a new form of in vivo molecular delivery system using light.Read moreRead less
A new in-situ structural measurement capability during nanoindentation. A new in-situ structural measurement capability during nanoindentation. This project aims to develop an in-situ Raman capability to obtain dynamic structural and mechanical behaviour of materials as a function of pressure during nanoindentation; and apply the new capability to directly monitor phase changes in silicon and germanium under pressure and correlate them with the simultaneous electrical responses. Anticipated outc ....A new in-situ structural measurement capability during nanoindentation. A new in-situ structural measurement capability during nanoindentation. This project aims to develop an in-situ Raman capability to obtain dynamic structural and mechanical behaviour of materials as a function of pressure during nanoindentation; and apply the new capability to directly monitor phase changes in silicon and germanium under pressure and correlate them with the simultaneous electrical responses. Anticipated outcomes are new instrumentation to directly probe the pressure-temperature phase diagram, and measure electrical properties of novel end phases in these semiconductors.Read moreRead less
Generalised Energy Based Robust and Nonlinear Control Systems. This project aims to develop new energy-based theories of robust stability analysis and controller design for both linear and nonlinear systems, building on passivity and negative imaginary system theories and their physical interpretations along with stochastic optimal control theory. These control theories would allow for a wide range of plant dynamics in the design of high-performance robust control systems, enabling advances in e ....Generalised Energy Based Robust and Nonlinear Control Systems. This project aims to develop new energy-based theories of robust stability analysis and controller design for both linear and nonlinear systems, building on passivity and negative imaginary system theories and their physical interpretations along with stochastic optimal control theory. These control theories would allow for a wide range of plant dynamics in the design of high-performance robust control systems, enabling advances in emerging technologies including nanopositioning, micro-electromechanical systems and opto-mechatronics. The project plans to combine these theoretical advances with numerical methods involving advanced optimisation tools and the experimental implementation of nanopositioning control systems in atomic force microscopy.Read moreRead less
ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reac ....ARC Centre of Excellence in Quantum Biotechnology. ARC Centre of Excellence in Quantum Biotechnology. The ARC Centre of Excellence in Quantum Biotechnology aims to develop paradigm-shifting quantum technologies to observe biological processes and transform our understanding of life. It seeks to create technologies that go far beyond what is possible today, from portable brain imagers to super-fast single protein sensors, and to use them to unravel key problems including how enzymes catalyse reactions and how higher brain function emerges from networks of neurons. By building a diverse, multidisciplinary, and industry-engaged ecosystem, the Centre means to develop our future leaders at the interface of quantum science and biology and drive Australian innovation across manufacturing, energy, agriculture, health, and national security.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE210100002
Funder
Australian Research Council
Funding Amount
$3,000,000.00
Summary
Australian Partnership in Advanced LIGO+: continuation. The aim of this project is, in collaboration with the USA and UK, to complete the installation and commissioning of the Advanced LIGO+ facilities in the USA in order to bring them to design sensitivity. These facilities expect to increase the event rate of gravitational wave signals by a factor of 125. This should lead to daily detections and the observation of new sources of gravitational waves. Given that only 5% of the universe is detect ....Australian Partnership in Advanced LIGO+: continuation. The aim of this project is, in collaboration with the USA and UK, to complete the installation and commissioning of the Advanced LIGO+ facilities in the USA in order to bring them to design sensitivity. These facilities expect to increase the event rate of gravitational wave signals by a factor of 125. This should lead to daily detections and the observation of new sources of gravitational waves. Given that only 5% of the universe is detectable by telescopes, the impact of gravitational wave detections on our understanding of the universe is inestimable. Australian partnership intends to enable our physicists and astronomers to be at the vanguard of this brand new field and inspire a new generation to study the physical sciences.Read moreRead less