Engineering drug transportation behaviour in polymeric gel systems. In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release ....Engineering drug transportation behaviour in polymeric gel systems. In collaboration with Seagull Technologies, this project aims to engineer, study and mathematically model ultrasound-assisted biomacromolecule transport behaviour within polymeric gel systems, which may be useful in new drug delivery methods. The intended outcome is a novel set of polymeric gel systems, which can reversibly bind a wide variety of drugs (small molecules, nucleic acid based drugs, proteins), in which drug release is triggered by an electric potential and drug transport is controlled by means of sonophoresis. The main advantage of drug delivery via sonophoresis is elimination of risks associated with injections such as infection and damage to local tissue, and elimination of patient discomfort, pain and fear.Read moreRead less
Versatile dosimetry systems for radiotherapy and industrial applications: novel storage phosphor and associated reader technologies. Radiotherapy is an important procedure in the treatment of cancer, and it is essential that the radiation dosage can be accurately measured. This project will develop technology which will enable us to monitor radiation dosage in real time and very accurately. This will be of importance in medical science and also for industrial applications.
A Nano-platform for affordable and ultra-sensitive bio-marker detection. This project aims to develop a next-generation nano-platform and lateral flow assays (LFA) device for ultra-sensitive detection of biomarkers. LFA’s are used for the rapid detection of biomarkers; however, their sensitivity is relatively low. The preparation of innovative porous silica nanoparticles with uniform particle size and controllable structures (pore size, pore structure, internal surface functionality and density ....A Nano-platform for affordable and ultra-sensitive bio-marker detection. This project aims to develop a next-generation nano-platform and lateral flow assays (LFA) device for ultra-sensitive detection of biomarkers. LFA’s are used for the rapid detection of biomarkers; however, their sensitivity is relatively low. The preparation of innovative porous silica nanoparticles with uniform particle size and controllable structures (pore size, pore structure, internal surface functionality and density) will enable higher loading of quantum dots and enhanced detection sensitivity. Improving the detection sensitivity of the inexpensive and disposable LFA diagnostic technology will open up new applications for rapid and accurate biomarker detection. The resulting technology will advance Australian industrial capability and competiveness in the global lateral flow assays market, which is estimated to be valued at US$ 6.78 billion by 2020.Read moreRead less
Development of a market relevant DNA nano-vaccine platform. DNA vaccine technology can potentially provide a rapid response to existing or new pathogens, but its market success has been limited. By addressing key scientific and technical challenges, this project aims to develop a new and cost-effective DNA nanovaccine platform using a multiscale engineering approach. It is anticipated that novel nanoparticles for DNA delivery and an end-user-driven DNA vaccine technology with enhanced immunogeni ....Development of a market relevant DNA nano-vaccine platform. DNA vaccine technology can potentially provide a rapid response to existing or new pathogens, but its market success has been limited. By addressing key scientific and technical challenges, this project aims to develop a new and cost-effective DNA nanovaccine platform using a multiscale engineering approach. It is anticipated that novel nanoparticles for DNA delivery and an end-user-driven DNA vaccine technology with enhanced immunogenicity, stability and safety will be generated. Expected outcomes include new knowledge in nanomaterial science and a market ready technology platform, improving Australia’s capabilities in nanobiotechnology and vaccine development, as well as delivering a new value-added product for the Industry Partner. Read moreRead less
Deciphering interactions of conducting polymers in agricultural soils. The project aims to improve agricultural efficiency, productivity and yield by advancing the understanding of polymer materials interacting with fertiliser. This project will test the key assumptions behind a new sensor for real-time in-ground monitoring of fertiliser. The expected outcome from this is the rapid synthesis of conducting polymers for stable sensing of fertiliser in a range of soil types and conditions. This sho ....Deciphering interactions of conducting polymers in agricultural soils. The project aims to improve agricultural efficiency, productivity and yield by advancing the understanding of polymer materials interacting with fertiliser. This project will test the key assumptions behind a new sensor for real-time in-ground monitoring of fertiliser. The expected outcome from this is the rapid synthesis of conducting polymers for stable sensing of fertiliser in a range of soil types and conditions. This should provide the pathway to a world first real-time in-ground fertiliser sensor, providing benefit for the sensor manufacturers, farmers, consumers and the environment.Read moreRead less
Ion-beam synthesis of functional oxides for next generation memory devices. This project seeks to explore a low-temperature approach to stoichiometry control using direct oxide synthesis and defect-engineering based on ion-implantation, a routine semiconductor fabrication process. This has the potential to improve device manufacturability and functionality. In thin film form, transition metal oxides can be subjected to intense electric fields and exhibit characteristic resistance changes suitabl ....Ion-beam synthesis of functional oxides for next generation memory devices. This project seeks to explore a low-temperature approach to stoichiometry control using direct oxide synthesis and defect-engineering based on ion-implantation, a routine semiconductor fabrication process. This has the potential to improve device manufacturability and functionality. In thin film form, transition metal oxides can be subjected to intense electric fields and exhibit characteristic resistance changes suitable for non-volatile memory applications. However, their electrical response depends critically on stoichiometry and this must be precisely engineered for optimal device performance. This project aims to develop next-generation memory devices as a replacement for current flash memory. The proposed technology uses resistance changes in functional-oxides to store information, and offers the potential for smaller and faster memory.Read moreRead less
Engineering a physiologically-relevant blood vessel in vitro . The project will develop an in vitro blood vessel model which will mimic arterial conditions by incorporating vascular cells and silk conduits as scaffolds, for the first time. This approach will overcome the limitations of simplistic 2D cell cultures, the long maturation times of fully tissue-engineered vessels, and resource intensive animal models. The innovative bioengineered construct proposed builds on the CI’s significant advan ....Engineering a physiologically-relevant blood vessel in vitro . The project will develop an in vitro blood vessel model which will mimic arterial conditions by incorporating vascular cells and silk conduits as scaffolds, for the first time. This approach will overcome the limitations of simplistic 2D cell cultures, the long maturation times of fully tissue-engineered vessels, and resource intensive animal models. The innovative bioengineered construct proposed builds on the CI’s significant advances in materials and surface engineering and the Partner Organisation’s (Codex Research) new bioreactor platform. It will offer a solution for modelling of native vessel processes in vitro that would be more appropriate for pre-clinical drug and device development, and in the long-term, tissue replacement.Read moreRead less
Controlling the forming and switching characteristics of non-volatile resistive memory devices using ion-implantation. This project will develop new techniques for improving the reliability and endurance of a new class of non-volatile memory devices for use in portable electronics and embedded electronic systems. Such developments are essential for the development of next-generation devices.
Printable technologies for high security documents and consumer products. Printable technologies for high security documents and consumer products. This project aims to develop two next-generation printable security feature technologies to protect users from counterfeiting, which costs the world economy billions in lost revenue and undermines the security of citizens. First, it aims to enhance the security of banknotes by developing printable active device patches with energy harvesting flexible ....Printable technologies for high security documents and consumer products. Printable technologies for high security documents and consumer products. This project aims to develop two next-generation printable security feature technologies to protect users from counterfeiting, which costs the world economy billions in lost revenue and undermines the security of citizens. First, it aims to enhance the security of banknotes by developing printable active device patches with energy harvesting flexible polymers as a power source and thin film graphene/polymer nanomaterial as an electrode/energy storage media. Second, it aims to design invisible carbon nanotube inks for optical authentication via near infrared activation. Both technologies are expected to thwart sophisticated counterfeits, particularly those supported by organised crime.Read moreRead less
The development of flexible, graded plasma surface engineered coatings for superior interfacial performance. The next generation of intraocular lenses, medical devices to treat patients with cataracts, will be developed through application of advanced surface engineering technologies. These superior coated lenses will improve biocompatibility and function, leading to additional benefit for the forecasted 2.7 million Australians with cataracts by 2021.