Selectivity enhancement in separation science using responsive materials. Increasing public demand for quality products from the chemical, pharmaceutical, biotechnology and food industries requires access to innovative methods of chemical analysis. This project will establish a new class of separation materials of enhanced selectivity and resolving power for the fast, sensitive and reliable analysis of these products.
A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological respon ....A Biologically Responsive and Anatomically Authentic Human Nasal Model. As respiratory conditions caused by pollutants and viruses become more prevalent, human nasal models to study infection/protection mechanisms and nasal drug/vaccine delivery are increasingly important. This project aims to develop a world-first human nasal model to mimic both anatomical and biological aspects of the nasal cavity and predict the distribution and deposition of fine particles and the resultant biological response from the nasal mucosa. The aim is to overcome a key fabrication challenge - to 3D print an anatomically accurate nasal construct with a porous wall on which to grow and mature functional nasal tissue that lines a nasal cavity wall. The benefit would be enabling faster development of more targeted drugs and vaccines.Read moreRead less
Improving the diagnosticity of eyewitness memory choices. Eyewitness identification error is common and costly. This project aims to improve the quality of information provided by eyewitnesses, and the ability of police officers and triers of fact (e.g., juries, judges) to evaluate this information. Laboratory investigations will determine how best to test memory and confidence to achieve this aim. A new class of cognitive models will provide a unified account of response accuracy, response time ....Improving the diagnosticity of eyewitness memory choices. Eyewitness identification error is common and costly. This project aims to improve the quality of information provided by eyewitnesses, and the ability of police officers and triers of fact (e.g., juries, judges) to evaluate this information. Laboratory investigations will determine how best to test memory and confidence to achieve this aim. A new class of cognitive models will provide a unified account of response accuracy, response time, and confidence, suitable for application to computerized testing scenarios. The models and testing methods validated in the laboratory will be refined for application in eyewitness memory settings, facilitating better evaluation of identification evidence, and potentially reducing wrongful convictions.Read moreRead less
Polymer Inclusion Membranes for Electrokinetic Sampling and Separation. This proposal aims to understand the chemical and physical properties governing the transport of ions into and within advanced extracting polymeric materials, known as polymer inclusion membranes, under the influence of an applied voltage. These membranes are dry-to-touch and represent a new and potentially powerful analytical platform for environmental, medical and industry sample preparation. By understanding the transport ....Polymer Inclusion Membranes for Electrokinetic Sampling and Separation. This proposal aims to understand the chemical and physical properties governing the transport of ions into and within advanced extracting polymeric materials, known as polymer inclusion membranes, under the influence of an applied voltage. These membranes are dry-to-touch and represent a new and potentially powerful analytical platform for environmental, medical and industry sample preparation. By understanding the transport mechanism, new membranes will be developed, capable of purifying and concentrating diverse targets chemicals from liquid and solid samples. These processes can take place during sample transportation to a centralised laboratory thus simplifying and streamlining analysis upon arrival to decrease drastically its costs.Read moreRead less
Advanced matrix-analytic methods with applications. Over the last twenty-five years, matrix-analytic methods have proved to be very successful in formulating and analysing certain classes of stochastic models. Motivated by applications, this project will investigate more advanced matrix-analytic methods than have hitherto been studied.
Microfluidic models of the CNS: Understanding cells, circuits & synapses. Aims: We aim to develop new cell culture platforms to form defined networks of brain cells. These platforms will be used to determine the critical mechanisms underpinning central nervous system function.
Significance: The devices developed will enable an unprecedented capacity to monitor changes throughout a network, with analysis at the level of the synapse, cell and circuit.
Expected outcomes: We will advance knowledge ....Microfluidic models of the CNS: Understanding cells, circuits & synapses. Aims: We aim to develop new cell culture platforms to form defined networks of brain cells. These platforms will be used to determine the critical mechanisms underpinning central nervous system function.
Significance: The devices developed will enable an unprecedented capacity to monitor changes throughout a network, with analysis at the level of the synapse, cell and circuit.
Expected outcomes: We will advance knowledge regarding the function of the CNS and deliver complex human cellular systems, that have both discovery and commercial applications.
Benefit: These platforms will have subsequent application revealing the mechanisms underlying numerous neurological diseases, with capacity to upscale for rapid drug screening.
Read moreRead less
The global consequences of subduction zone congestion. This project will use a combination of 3D geodynamic modelling, plate kinematic reconstruction and geological and geophysical synthesis to determine how congested subduction zones influence plate kinematics, subduction dynamics and tectonic evolution at orogen and global scales. The project aims to deliver a transformation change in understanding the links between congested subduction, mantle flow, trench migration, crustal growth, transitio ....The global consequences of subduction zone congestion. This project will use a combination of 3D geodynamic modelling, plate kinematic reconstruction and geological and geophysical synthesis to determine how congested subduction zones influence plate kinematics, subduction dynamics and tectonic evolution at orogen and global scales. The project aims to deliver a transformation change in understanding the links between congested subduction, mantle flow, trench migration, crustal growth, transitions between stable convergent margin configurations and deformation in the overriding plates of subduction zones. Determining these relationships is significant because it will provide dynamic context to interpret the geological record of ancient convergent margins, which host a large percentage of Earth's metal resources.Read moreRead less
Place, Commonality and the Human: Towards a New Philosophical Anthropology. This project proposes a new philosophical vision of what it means to be human. Combining historical and conceptual approaches, the project aims to develop a new philosophical anthropology that centres on understanding human beings in terms of both place and commonality. This account is designed to provide the basis for a rethought conception of the ethics that are bound to human life and that understands the ethical as e ....Place, Commonality and the Human: Towards a New Philosophical Anthropology. This project proposes a new philosophical vision of what it means to be human. Combining historical and conceptual approaches, the project aims to develop a new philosophical anthropology that centres on understanding human beings in terms of both place and commonality. This account is designed to provide the basis for a rethought conception of the ethics that are bound to human life and that understands the ethical as essentially a matter of judgment rather than prescriptive rule. Given the centrality of the concept of the human to any thinking about our contemporary situation, the project would have both applied and interdisciplinary relevance.Read moreRead less
Linking wave–sea ice feedbacks to rapid ice retreat. Antarctic sea ice extent has been in sharp decline since 2016, which is stressing the fragile Southern Ocean and Antarctic environments so vital to the global climate. This project aims to investigate a crucial candidate mechanism of sea ice loss by predicting rapid ice retreat in response to large Southern Ocean waves. New theory and modelling capabilities that account for wave–ice feedbacks will underpin the predictions, leveraging on recent ....Linking wave–sea ice feedbacks to rapid ice retreat. Antarctic sea ice extent has been in sharp decline since 2016, which is stressing the fragile Southern Ocean and Antarctic environments so vital to the global climate. This project aims to investigate a crucial candidate mechanism of sea ice loss by predicting rapid ice retreat in response to large Southern Ocean waves. New theory and modelling capabilities that account for wave–ice feedbacks will underpin the predictions, leveraging on recent research breakthroughs, including novel datasets derived from satellite and field observations. The outcomes are expected to quantify sea ice retreat due to ocean waves for the first time, with potentially major implications for coupled wave–sea ice modelling in climate studies.Read moreRead less
Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encodi ....Developing a Unified Theory of Episodic Memory. This project aims to develop a model of episodic memory and to apply the model to both adult and child development data. Unlike current approaches, the model is expected to address multiple memory tasks including item recognition, associative recognition, source recognition and cued recall, and also aims to address reaction time data, allowing different sources of interference causing forgetting in adults to be identified. By addressing both encoding and retrieval processes, the model can assess how changes in different sources of interference modulate performance through the trajectory of early development. Hierarchical Bayesian estimation aims to enable a simultaneous account of multiple tasks and support future deployment in applied contexts.Read moreRead less