Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principl ....Engineering an artificial protein molecular motor. This project aims to use non-motor protein building blocks to construct an artificial protein motor. Nature already uses nanotechnology as the basis for all its machinery, and uses proteins to construct machines. Each protein component in the motor will have a well-understood function; this artificial protein will elucidate how it converts chemical energy to motion. This process is not understood as molecular motors do not obey the same principles as macroscopic machines. Comparing the artificial motor with biological motors will provide insight into the workings of natural motors. This project should lead to molecular motors for nanobiotechnology.Read moreRead less
3D Bipolar Electroactive Architectures for Wireless BioStimulation. Traditional Electrostimulation requires hard-wired metal electrodes and electronic wires connected to a power supply. These tethered systems face numerous challenges in establishing long-lasting effective electronic interfaces with targeted cells and tissues. This project aims to combine technologies in conductive polymers, bipolar electrochemistry, 3D fabrication and cell engineering to develop a 3D bioelectronic system that e ....3D Bipolar Electroactive Architectures for Wireless BioStimulation. Traditional Electrostimulation requires hard-wired metal electrodes and electronic wires connected to a power supply. These tethered systems face numerous challenges in establishing long-lasting effective electronic interfaces with targeted cells and tissues. This project aims to combine technologies in conductive polymers, bipolar electrochemistry, 3D fabrication and cell engineering to develop a 3D bioelectronic system that enables wireless cell stimulation. The major benefit is to generate advanced knowledge of wireless powered electromaterials and novel wireless biotechnology in medical engineering, which could help well-position the Australian in smart bionic devices for human well-being with a bright future.Read moreRead less
Organic Bioelectronics: Solving Key Barriers to Precision Neuromodulation. This project aims to combine the principles of molecular electronics and neurobiology to create organic conductors with enhanced biocompatibility that enable optical neuromodulation. This project expects to generate new knowledge regarding the properties of materials that promote connectivity with neurons and the ability of new microscopy tools to visualise this bio-interface. The expected outcome of this project includes ....Organic Bioelectronics: Solving Key Barriers to Precision Neuromodulation. This project aims to combine the principles of molecular electronics and neurobiology to create organic conductors with enhanced biocompatibility that enable optical neuromodulation. This project expects to generate new knowledge regarding the properties of materials that promote connectivity with neurons and the ability of new microscopy tools to visualise this bio-interface. The expected outcome of this project includes new high performing materials, measurement tools and fabrication approaches to overcome the key challenges to precision neuromodulation. A significant benefit of the new materials is their printability, providing the opportunity to establish a sovereign capability to manufacture low-cost bioelectronic systems in Australia.Read moreRead less
Ferroelectric bilayer composites with giant electromechanical properties. This project aims to create a novel bilayer ferroelectric material structure that provides giant electromechanical response at the nano-scale. Traditional electromechanical devices based on ferroelectric materials including position sensors, mechanical actuators, and ultrasonic transducers rely on bulk form. As technology moves toward integrated functionalities, future electro-mechanical materials need to be scaled down t ....Ferroelectric bilayer composites with giant electromechanical properties. This project aims to create a novel bilayer ferroelectric material structure that provides giant electromechanical response at the nano-scale. Traditional electromechanical devices based on ferroelectric materials including position sensors, mechanical actuators, and ultrasonic transducers rely on bulk form. As technology moves toward integrated functionalities, future electro-mechanical materials need to be scaled down to thin film form. Currently, doing this induces mechanical constraints that dramatically suppress the electromechanical response. Using this approach one layer relieves this mechanical constraint while the other gives a giant electromechanical response, providing a pathway for future functional devices. Read moreRead less
It’s a fine line: analytical and experimental optimisation of drawing metal-in-dielectric nanowire composites to manufacture engineered metamaterials. Exploitation of ‘smart materials’ is a major opportunity for 21st century Australian manufacturing if cost effective bulk production is available. Metamaterials are ideal building blocks for such new-age materials, being dielectric/metal composites structured on sub-wavelength dimensions, offering diverse properties unavailable in natural material ....It’s a fine line: analytical and experimental optimisation of drawing metal-in-dielectric nanowire composites to manufacture engineered metamaterials. Exploitation of ‘smart materials’ is a major opportunity for 21st century Australian manufacturing if cost effective bulk production is available. Metamaterials are ideal building blocks for such new-age materials, being dielectric/metal composites structured on sub-wavelength dimensions, offering diverse properties unavailable in natural materials. Fibre drawing is a proven mass-production technology for translating the structure of a (macroscale) preform to microscale and has recently been applied it to fabricate microscale metamaterials. By overcoming fundamental instabilities, this project will transform the technique to manufacture nanoscale structured composites and demonstrate practical metamaterial-based optical devices with unique properties.Read moreRead less
Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will re ....Engineering floating liquid marbles for three-dimensional cell cultures. This project aims to understand the physics of three-dimensional cell cultures in a liquid marble floating on a liquid free surface. New methodology developed can produce these cell cultures without using matrices or scaffolds and with run-times well beyond existing technologies. This methodology closely mimics a normal in-vivo environment and produces spheroids needed in cell transplantation therapies. This project will resolve uncertainties in the underlying phenomena. The expected outcome should support future high quality cell cultures suitable for transplantation therapies.Read moreRead less
Seeing the Bio-Nano "Talk" in the brain via real-time multiplex tracking. This project aims to develop new knowledge and smart tools that have the potential to greatly improve brain research. The blood-brain-barrier is the major physiological barrier that protects the brain from environmental toxins, bacteria and viruses, but limits the effectiveness of nanoparticle-based brain imaging agents. Expected outcomes of this project include a better understanding of the mechanisms that allow nanoparti ....Seeing the Bio-Nano "Talk" in the brain via real-time multiplex tracking. This project aims to develop new knowledge and smart tools that have the potential to greatly improve brain research. The blood-brain-barrier is the major physiological barrier that protects the brain from environmental toxins, bacteria and viruses, but limits the effectiveness of nanoparticle-based brain imaging agents. Expected outcomes of this project include a better understanding of the mechanisms that allow nanoparticles to penetrate the blood-brain-barrier, as well as improving brain imaging. Benefits of the project include the commercialisation of technologies and smarl tools developed in this projetct, and establishment of a new Australian biotechnology company that exports brain-imaging technologies to the world.Read moreRead less
Indistinguishable Quantum Emitters in van der Waals Materials. Solid state sources of single photons ("quantum emitters") are a key building block for implementation of scalable quantum technologies. Amongst many potential platforms studied, impurities in hexagonal boron nitride (hBN) are at the forefront due to their brightness and ease of manufacturing. However, their main disadvantage is spectral instability which prohibits engineering of practical devices. The current project will address th ....Indistinguishable Quantum Emitters in van der Waals Materials. Solid state sources of single photons ("quantum emitters") are a key building block for implementation of scalable quantum technologies. Amongst many potential platforms studied, impurities in hexagonal boron nitride (hBN) are at the forefront due to their brightness and ease of manufacturing. However, their main disadvantage is spectral instability which prohibits engineering of practical devices. The current project will address this bottleneck and deliver an optically stable solid state quantum light source in hBN. The project will produce a robust hardware toolkit for quantum technologies. It will provide excellent training for young Australians and generate key intellectual property for quantum startups and the quantum industry.Read moreRead less
Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are inn ....Advancing the visualisation and quantification of nephrons with MRI. . This project aims to characterise key components of nephrons, the glomeruli and tubules, using magnetic resonance imaging without contrast agents, in combination with Deep Learning and super-resolution techniques. Nephrons, the basic functional unit of the kidney, are critical to the maintenance of the body’s homeostasis. Their number and architecture are critical determinants of kidney function. The expected outcomes are innovative semi-automated nephron visualisation and quantitation tools that enable efficient renal phenotyping. Techniques tailored to widely accessible preclinical research scanners are expected to accelerate research into genetic and environmental factors affecting kidney microstructure in embryonic and post-natal life.Read moreRead less
Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions. Nanomaterials exposed to biological environments such as blood or lymph fluids rapidly adsorb a layer of biomolecules on their surface, forming a biomolecular corona, and profoundly altering their properties. This project aims to resolve the influence of biomolecular coronas on nanoparticle–immune cell interactions by combining particle engineering, immunology, proteomics and bioinformatic analysis. The project expected outc ....Impact of Biological Coatings on Nanoparticle–Immune Cell Interactions. Nanomaterials exposed to biological environments such as blood or lymph fluids rapidly adsorb a layer of biomolecules on their surface, forming a biomolecular corona, and profoundly altering their properties. This project aims to resolve the influence of biomolecular coronas on nanoparticle–immune cell interactions by combining particle engineering, immunology, proteomics and bioinformatic analysis. The project expected outcomes are to generate new knowledge in nanomaterial–immune cell behaviour and design principles for nanoparticles with prospective applications in the agricultural, veterinary and biomedical sectors.Read moreRead less