A Randomised Trial Of Zoledronic Acid For Osteoarthritis Of The Knee
Funder
National Health and Medical Research Council
Funding Amount
$989,238.00
Summary
Osteoarthritis (OA) is the most common form of arthritis and is increasing markedly due to an ageing population. Despite its large disease burden, there are currently no approved disease-modifying drugs available which modify structural progression of OA. The aim of this study is to compare zoledronic acid treatment to placebo on knee structural change and knee pain over two years. It is hypothesised that zoledronic acid will reduce cartilage loss, knee pain, and bone marrow lesion size.
ENDOGENOUS PAIN RELIEF IN HEALTHY AND OSTEOARTHRITIC PATIENTS
Funder
National Health and Medical Research Council
Funding Amount
$509,926.00
Summary
Pain has a detrimental impact on ones quality of life and a significant financial impact on the community. Given this, there is a substantial effort aimed at developing pain relieving compounds. One way in which our own brain can provide complete pain relief is via a mechanism called diffuse noxious inhibitory control. We currently do not know how this mechanism works and the aim of this investigation is to explore this mechanism in healthy and osteoarthritis patients use human brain imaging.
Efficacy Of A Physiotherapy Treatment For Knee Joint Osteoarthritis: A Randomised, Double-blind, Controlled Trial
Funder
National Health and Medical Research Council
Funding Amount
$156,743.00
Summary
Osteoarthritis of the knee is a disabling condition affecting the lining of the joints giving rise to pain and stiffness. It is common in older individuals and is a major cause of disability. Physiotherapy is often used to decrease pain and improve muscle strength and functional ability. However, there are few well controlled scientific studies which prove the efficacy of physiotherapy as a form of treatment in this condition. This project aims to establish whether a 12 week course of physiother ....Osteoarthritis of the knee is a disabling condition affecting the lining of the joints giving rise to pain and stiffness. It is common in older individuals and is a major cause of disability. Physiotherapy is often used to decrease pain and improve muscle strength and functional ability. However, there are few well controlled scientific studies which prove the efficacy of physiotherapy as a form of treatment in this condition. This project aims to establish whether a 12 week course of physiotherapy treatment is effective in reducing pain and improving function in 50-80 year old individuals diagnosed with osteoarthritis of the knee joint. It will also assess whether any improvements seen after treatment can be maintained with a home program. This will provide scientific evidence to justify the role of physiotherapy management in this condition.Read moreRead less
This research program aims to utilise three new clinical trials to treat pain from osteoarthritis of the knee and hand. These treatments use existing medications, but for new indications. This project will determine if these treatments reduce pain and slow structural changes over two years of treatment. It also has the potential to develop the first treatment for osteoarthritis which changes the natural course of the disease rather than merely treating symptoms.
Hype Or Hope? Platelet-Rich Plasma As A Symptom- And DisEaSe-modifying Treatment FOR Knee OstEoarthritis - The RESTORE Trial
Funder
National Health and Medical Research Council
Funding Amount
$1,400,359.00
Summary
Knee osteoarthritis (OA) is a major public health problem worldwide with no cure. Thus safe and effective treatments that reduce symptoms and slow structural disease progression are needed. This clinical trial aims to test the effects of injections of platelet-rich plasma (a blood product) into the knee on pain and joint structure in 288 people with knee OA. The results will provide high quality evidence to determine whether platelet rich plasma should be used to treat knee OA.
Does Low Dose Amitriptyline Reduce Pain In Knee Osteoarthritis? A Double Blind, Randomised, Pragmatic, Placebo Controlled Clinical Trial Of Amitriptyline In Addition To Usual Care
Funder
National Health and Medical Research Council
Funding Amount
$413,704.00
Summary
Pain is the main problem for people with osteoarthritis, a common form of arthritis. This pain is not controlled well. Pain comes from structural changes in the joint. However, after time, some people develop pain due to changes in the nervous system, called pain sensitisation. This is not affected by usual treatments. Amitriptyline is used to treat pain sensitisation. This study is a randomised trial to see whether amitriptyline, relieves pain in people with knee osteoarthritis over 3 months.
Using Magnetic Resonance Imaging (MRI) To Improve Understanding Of Knee Osteoarthritis And Develop Effective Therapeutic Treatments
Funder
National Health and Medical Research Council
Funding Amount
$299,564.00
Summary
Osteoarthritis is the most common form of arthritis and is increasing markedly due to an ageing population. This program of research uses magnetic resonance imaging (MRI) to improve our understanding about knee osteoarthritis. It will examine knee structural change over time using unique 10-year follow-up MRI measures from a pre-existing case-control study. This program of research will also examine two randomised controlled trials which aim to evaluate therapeutic treatments for the disease.
A Randomised Trial Of Krill Oil For Osteoarthritis Of The Knee
Funder
National Health and Medical Research Council
Funding Amount
$751,491.00
Summary
This study trials krill oil vs placebo, for painful knee osteoarthritis in people with joint swelling on MRI scans, to assess if krill oil reduces knee pain and knee swelling over 24 weeks. If krill oil can delay loss of knee cartilage through effects on cartilage and bone, this this could lead to a delay in the time to knee replacement surgery and improvements in quality of life for those suffering from OA.
From Imaging To Intervention In Osteoarthritis And Back Pain
Funder
National Health and Medical Research Council
Funding Amount
$318,768.00
Summary
Osteoarthritis and back pain are regarded as cartilage disorders, however recent evidence suggests that underlying bone and joint fluid pathology are also involved. This project takes a unique approach of targeting bone and joint fluid pathology of knee osteoarthritis and back pain, and will test the effects of existing therapies and krill oil through clinical trials. If successful, it will have the potential to slow progression to joint replacement through an easy method of implementation.
DICKENS - A Randomised Controlled Trial Of DIaCerein To Treat KneE Osteoarthritis With EffusioN-Synovitis
Funder
National Health and Medical Research Council
Funding Amount
$1,327,836.00
Summary
Knee osteoarthritis (OA) is common, but the current treatments are poor. Almost 60% of people with knee OA have joint inflammation. Patients with inflammation are more likely to experience joint pain and rapid joint destruction. We propose that treating patients with inflammatory knee OA with the anti-inflammatory drug, diacerein, will reduce pain and joint damage.