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Driving Change To Improve Aboriginal And Torres Strait Islander Kidney Health
Funder
National Health and Medical Research Council
Funding Amount
$1,050,000.00
Summary
The burden of kidney disease affecting Aboriginal and Torres Strait Islander communities is devastating. Community members prioritise prevention of kidney disease, early detection and treatment to stop progression to dialysis. In remote areas, people requiring dialysis have to move away from their family and supports. This work will focus on innovative ways to address this disparity to improve care, treatment and services for Indigenous people living with kidney disease.
Developing Novel Therapeutic Approaches To Treat Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$2,173,545.00
Summary
Progression of chronic kidney disease (CKD) to endstage is characterised by inflammation and fibrosis. No current treatment effectively halts CKD progression. We are using protective immune cells to treat CKD and have invented a genetically-engineered immune cell which uses damaging inflammatory signals to switch them into protective cells which reverse inflammation and fibrosis where they occur, to prevent progression of CKD and other diseases, such as those of heart, lung and liver.
Improving Patient-important Outcomes In Haemodialysis Through Validation And Implementation In Registries And Pragmatic Clinical Trials
Funder
National Health and Medical Research Council
Funding Amount
$408,082.00
Summary
Haemodialysis is the most common treatment for kidney failure but is associated with poor survival, high symptom burden and drastically reduced quality of life. Research often does not address these patient-important outcomes, thereby limiting our ability to discover effective interventions. This program aims to improve haemodialysis outcomes that are critically important to patients and clinicians through validation and implementation in clinical practice, registries and clinical trial.
Partnering With Patients To Transform Practice And Policy For Improved Patient-centred Outcomes In Chronic Kidney Disease
Funder
National Health and Medical Research Council
Funding Amount
$3,292,932.00
Summary
Chronic kidney disease (CKD) is a major cause of death and imposes a substantial burden on individuals and the healthcare system worldwide. In partnership with patients, this project will establish and implement core outcomes and measures. Patient-centred trials will address the research priorities of patients across all stages of CKD including: preventing the progression of CKD, improving fatigue in patients on dialysis, and optimising life participation in kidney transplant recipients.
Bridging The Gap: Using Data Science To Transform Care And Health Outcomes In Kidney Transplant Recipients
Funder
National Health and Medical Research Council
Funding Amount
$1,155,135.00
Summary
Despite substantive survival and quality of life benefits compared to being on dialysis, kidney transplant recipients suffer from premature death, largely due to complications such as cancer and cardiovascular. Using big data science, we will be able to predict these complications in the context of chronic immunosuppression, find new and better ways to identify at risk individuals, to deliver effective and efficient screening and treatment strategies in this vulnerable population.