The Thrombospondin-1/CD47 Axis In Kidney Transplantation.
Funder
National Health and Medical Research Council
Funding Amount
$372,528.00
Summary
Kidney transplantation is the preferred treatment for kidney failure. At transplantation when blood flow is restored to the organ, a massive burst of inflammatory and oxidative products ensues, a process known as “ischaemia-reperfusion injury” (IRI). This damages transplanted organs and activates the immune system, causing organ transplant rejection and loss. This project will investigate the TSP-1/CD47 axis and its manipulation in renal IRI as a focus for reducing organ injury, rejection and tr ....Kidney transplantation is the preferred treatment for kidney failure. At transplantation when blood flow is restored to the organ, a massive burst of inflammatory and oxidative products ensues, a process known as “ischaemia-reperfusion injury” (IRI). This damages transplanted organs and activates the immune system, causing organ transplant rejection and loss. This project will investigate the TSP-1/CD47 axis and its manipulation in renal IRI as a focus for reducing organ injury, rejection and transplant failure.Read moreRead less
Epigenetic Hyperglycemic Cell Memory Causes Vascular Complications In Type 1 Diabetes
Funder
National Health and Medical Research Council
Funding Amount
$332,140.00
Summary
This project seeks to identify how epigenetic change in response to hyperglycemia can cause vascular complications of diabetes, and how this contributes to “hyperglycemic memory”; a phenomena where cells may undergo gene modifications which increase risk to further complications later in a patients life. These studies are the first of their kind and will characterize the types of epigenetic change that can cause human disease.