Ubiquitin And SUMO DNA Damage Response Signalling At Deprotected Telomeres During The Cell Cycle
Funder
National Health and Medical Research Council
Funding Amount
$302,627.00
Summary
Following genome damage cells stop the cell division process and initiate DNA repair. We discovered that at specific times during cell division his does not happen if the damage signals originate from the chromosome ends (i.e. “telomeres”). We anticipate this is necessary to prevent genomic instability in healthy cells and may be driving genomic instability in cancer cells. Experiments described here will elucidate the molecular mechanisms and biological significance of our observation.
Mechanisms Of Premature Cranial Fusion: Role Of Retinol Binding Protein 4 In Osteogenesis And Suture Fusion
Funder
National Health and Medical Research Council
Funding Amount
$555,855.00
Summary
Craniosynostosis is a condition where the skull bones fuse prematurely, affecting skull shape, vision and cognition. It occurs in 1 in 2,500 births. The only treatment is surgery, which is life-threatening, costly and may need to be repeated. By studying how fusion happens in this project we may be able to devise therapies to minimize the risks and need for re-operation. Here, we hope to show that modification of a single substance in the skull of mouse models can prevent premature bone fusion.
A nation of 'Good Sports'? Cultural citizenship and sport in contemporary Australia. Australia is widely regarded as both characterised and united by sport, but the established sport-nation nexus is undergoing significant change. This project addresses current uses and meanings of sport, media and spectatorship in advancing knowledge and policy relating to sport's dynamic relationship to national identity and cultural citizenship.
Communicating with people who have limited English proficiency. This sociolinguistic project aims to investigate how fluent English speakers interact with people who have limited proficiency. In contemporary Australia such mundane interactions may determine employment, education or health outcomes. While research into language barriers has mostly focused on the experiences of migrants from non-English-speaking backgrounds, this project will investigate how English speakers deal with increasing l ....Communicating with people who have limited English proficiency. This sociolinguistic project aims to investigate how fluent English speakers interact with people who have limited proficiency. In contemporary Australia such mundane interactions may determine employment, education or health outcomes. While research into language barriers has mostly focused on the experiences of migrants from non-English-speaking backgrounds, this project will investigate how English speakers deal with increasing linguistic diversity. Expected outcomes include an understanding of the role of majority members in facilitating the integration of newcomers. This will provide significant socioeconomic benefits for institutions and individuals as they navigate everyday intercultural communication.Read moreRead less
Improving Communication with Aboriginal English Speakers: A Study of cultural conceptualisations in Aboriginal English. The project will explore cultural conceptualisations in Aboriginal English. Often unfamiliarity with Aboriginal cultural conceptualisations on the part of non-Aboriginal people leads to miscommunication, disadvantaging Aboriginal speakers, especially in institutional contexts (for example, schoolrooms, courtrooms, Centrelink offices). The aim of this study is to alleviate such ....Improving Communication with Aboriginal English Speakers: A Study of cultural conceptualisations in Aboriginal English. The project will explore cultural conceptualisations in Aboriginal English. Often unfamiliarity with Aboriginal cultural conceptualisations on the part of non-Aboriginal people leads to miscommunication, disadvantaging Aboriginal speakers, especially in institutional contexts (for example, schoolrooms, courtrooms, Centrelink offices). The aim of this study is to alleviate such problems, and significantly advance Aboriginal English research, by exploring culturally constructed conceptualisations, in particularly cultural-conceptual metaphor, underlying the use of Aboriginal English, using the the analytical tools of Cultural Linguistics. The study will also make a significant contribution to the development of Cultural Linguistics. Read moreRead less
Voice, indexicality and the mediation of diversity on Australian television. Multicultural Australia is a country of many voices, although concern has been expressed about the under-representation of those voices in the media. This project investigates how the voices of minority groups are represented on mainstream Australian television, when they do appear. It examines a substantial body of TV data, from four types of programming: news, sports, advertising and drama. It focuses on minority ethn ....Voice, indexicality and the mediation of diversity on Australian television. Multicultural Australia is a country of many voices, although concern has been expressed about the under-representation of those voices in the media. This project investigates how the voices of minority groups are represented on mainstream Australian television, when they do appear. It examines a substantial body of TV data, from four types of programming: news, sports, advertising and drama. It focuses on minority ethnic voices and on voices linked to different social classes. Close analysis of media processes will be supplemented by consulting professionals and TV viewers. The findings will provide a new perspective on the media’s role in promoting or curtailing cultural literacy and linguistic diversity.Read moreRead less
Projecting Difference: A History of the Practice and Politics of French Cinema since 1980. This cultural history project has dual aims. Firstly, it will examine how French cinema, as a narrative art, has since the late 20th century become a major vector for defining cultural identity (partially eclipsing the role traditionally occupied by literature). On the other hand, it will document and analyse the processes by which cinema practice - diverse and often fractiously critical of existing politi ....Projecting Difference: A History of the Practice and Politics of French Cinema since 1980. This cultural history project has dual aims. Firstly, it will examine how French cinema, as a narrative art, has since the late 20th century become a major vector for defining cultural identity (partially eclipsing the role traditionally occupied by literature). On the other hand, it will document and analyse the processes by which cinema practice - diverse and often fractiously critical of existing political structures - has become a central symbolic weapon in the French State's political defence of cultural autonomy and difference in a globalising world. The resulting synthesis will provide extensive new understanding of the dynamics of contemporary France.Read moreRead less
The global self: screening the history of human rights in the 20th century to the present. This project will research the history and theory of human rights as represented in film and new media. It will analyse the origins and development of human rights theory and document the changes in films about human rights in order to understand how we now conceptualise human rights in the twenty-first-century.
Reconceiving the queer public sphere: an interdisciplinary analysis of same-sex couple domesticity. Using literary, biographical and photographic sources, this project will produce a ground-breaking history of same-sex domestic environments across the twentieth century. Critically analysing queer home life, this project will transform current understandings of the relation between homosexuality, private life and the public sphere.