Nicotinamide Adenine Dinucleotide (NAD+)-raising Agents For Improving Oocyte Quality
Funder
National Health and Medical Research Council
Funding Amount
$445,827.00
Summary
Many women cannot have children because of suboptimal egg quality, often due to aging. Currently, the only option is to use better quality eggs donated from another woman. This project will use pharmacological agents to promote recently discovered pathways in eggs central to determining quality. Importantly, we will investigate a simple and practical approach that can be used in clinics for augmenting these pathways to improve oocyte quality for the first time.
A New Direction For TB Control In Highly Endemic Countries: A RCT Of Active Case Finding
Funder
National Health and Medical Research Council
Funding Amount
$1,362,910.00
Summary
Tuberculosis is the number 1 health problem in Vietnam . Many people with TB do not know they have the disease but are infectious to others. Hence, the disease continues to spread. This project will investigate the role of x-ray screening to detect and treat more people with TB, particularly those who do not have symptoms. This may be an important element of future TB control programs in Vietnam and elsewhere in our region.
A Randomized Clinical Trial Comparing Effectiveness Of 4RIF And 9INH For Treatment Of Latent TB Infection
Funder
National Health and Medical Research Council
Funding Amount
$496,875.00
Summary
Treatment of latent tuberculosis infection (LTBI) is one intervention that is known to prevent the occurrence of active TB. Current treatment is based on a six to nine month course of isoniazid. The treatment has side effects in some people and many people do not complete the treatment. The present study is to test an alternative treatment regimen (4 months of rifampicin) which has fewer side-effects and is more likely to be completed.
A formal foundation for security architecture. Security of computer systems is essential for the maintenance of privacy, confidentiality and integrity of personal, commercial and government data, and the trustworthiness of the computational devices that are embedded in critical societal infrastructure. However, current theoretical understanding of secure systems development is poor. The project will develop our understanding of an emerging approach to the design of secure systems and develop ver ....A formal foundation for security architecture. Security of computer systems is essential for the maintenance of privacy, confidentiality and integrity of personal, commercial and government data, and the trustworthiness of the computational devices that are embedded in critical societal infrastructure. However, current theoretical understanding of secure systems development is poor. The project will develop our understanding of an emerging approach to the design of secure systems and develop verification methods that may be applied to guarantee systems security. Its outcomes will contribute to processes for certifying systems at very high levels of security, a requirement in defence and government settings that will become increasingly significant in the commercial sector.Read moreRead less
Implementing Feferman-Landin Logic. The objective of this project is to utilise computer based verification tools (such as PVS and Rewritting Logic) to develop a software engineering environment for specifying and verifying systems written in high-level programming languages such as Java, Scheme, and ML. The project will thus subtantially advance the use of formal computer based tools to develop reliable programs and specifications for life-critical systems. The project will also develop form ....Implementing Feferman-Landin Logic. The objective of this project is to utilise computer based verification tools (such as PVS and Rewritting Logic) to develop a software engineering environment for specifying and verifying systems written in high-level programming languages such as Java, Scheme, and ML. The project will thus subtantially advance the use of formal computer based tools to develop reliable programs and specifications for life-critical systems. The project will also develop formally
based interoperability between the PVS and Maude systems, two widely
used computer tools for reasoning about complex systems.Read moreRead less
Refinement of Temporal and Epistemic Specifications in Asynchronous Systems. Designing distributed systems is a complex activity requiring rigorous mathematical models of designs and specifications. It is desirable for the mathematical notations to be as close as possible to intuitive notions used by designers. One such notion is the idea that components in a distributed system have states of knowledge. Previous work has developed a calculus enabling derivation of systems with global clock by s ....Refinement of Temporal and Epistemic Specifications in Asynchronous Systems. Designing distributed systems is a complex activity requiring rigorous mathematical models of designs and specifications. It is desirable for the mathematical notations to be as close as possible to intuitive notions used by designers. One such notion is the idea that components in a distributed system have states of knowledge. Previous work has developed a calculus enabling derivation of systems with global clock by series of correctness-preserving transformations from a knowledge-based specification. This project will generalize this work to a calculus for systems that lack a global clock, and implement a tool providing automated support for use of the calculus.Read moreRead less
Foundations of Executable Temporal Logic. In many computer applications, including those of temporal reasoning, distributed computations and knowledge representations, the concept of time is of central importance. Multiple granularity of time also plays a critical role as not all events are necessarily defined over a uniform model of time. This project will develop the foundations of executable logical representations, supporting multiple granularity of time. This will allow system developers a ....Foundations of Executable Temporal Logic. In many computer applications, including those of temporal reasoning, distributed computations and knowledge representations, the concept of time is of central importance. Multiple granularity of time also plays a critical role as not all events are necessarily defined over a uniform model of time. This project will develop the foundations of executable logical representations, supporting multiple granularity of time. This will allow system developers access to powerful logical techniques in those applications. In the process, fundamental problems in modelling multiple granularity of time will be identified, and application-independent solutions to those problems will be provided.Read moreRead less
Economical and practical design and analysis of probabilistic distributed systems. Complex computing systems composed of communicating processes are
distributed over networks, and interact with embedded hardware
components. They routinely operate in probabilistic environments:
hardware components fail randomly, but at known rates; and tactical
randomisation resolves competition for resources. Effective
specification, development and analysis methods for these systems
is crucial, and probab ....Economical and practical design and analysis of probabilistic distributed systems. Complex computing systems composed of communicating processes are
distributed over networks, and interact with embedded hardware
components. They routinely operate in probabilistic environments:
hardware components fail randomly, but at known rates; and tactical
randomisation resolves competition for resources. Effective
specification, development and analysis methods for these systems
is crucial, and probability makes that particularly difficult.
The focus of this project is to develop new formal methods that are
economical and practical in use. Exploiting our recent advances in
probabilistic program semantics, we will add probability in a new
way to proven techniques in concurrency theory, including
refinement and hierarchical design.Read moreRead less
Algebraic reasoning for serialisability in probabilistic transaction systems. The ability to analyse complex systems is a vital part of the development of large-scale computer applications; a method that improves the quality of the analysis task would increase the competitiveness of the software industry, would attract future development work (in complex and intelligent systems) to Australia, and could contribute to national security.
The results of this project will have a direct influence ....Algebraic reasoning for serialisability in probabilistic transaction systems. The ability to analyse complex systems is a vital part of the development of large-scale computer applications; a method that improves the quality of the analysis task would increase the competitiveness of the software industry, would attract future development work (in complex and intelligent systems) to Australia, and could contribute to national security.
The results of this project will have a direct influence on currently available design tools; the fact that Australian institutions will be responsible for key theoretical results in this growing field will strengthen Australia's position worldwide as an international centre for computer science.Read moreRead less
Hidden-state modelling for modular analysis of information flow, protection and risk evaluation. Automation is increasing explosively, and the cliche is no longer that there is a cpu chip in your washing machine, television or automobile. Nowadays they are potentially in our cash cards, passports and soon on every item in our shopping baskets. Australia is a leader in adopting and developing such technology.
Security and privacy, hard enough for PCs, thus concerns smaller, more numerous devi ....Hidden-state modelling for modular analysis of information flow, protection and risk evaluation. Automation is increasing explosively, and the cliche is no longer that there is a cpu chip in your washing machine, television or automobile. Nowadays they are potentially in our cash cards, passports and soon on every item in our shopping baskets. Australia is a leader in adopting and developing such technology.
Security and privacy, hard enough for PCs, thus concerns smaller, more numerous devices that we might not even realise we are using.
Our research aims to make it easier and more effective to describe and then successfully build-in features that enforce security without adverse impact on usability.Read moreRead less