Novel Ophthalmic Topical Formulation Targeting Molecular Pathogenesis Of Corneal Haze
Funder
National Health and Medical Research Council
Funding Amount
$296,090.00
Summary
Presently, no drugs are proven to cure corneal haze/scarring, major leading cause of global blindness. Haze is caused by eye trauma, infections or refractive laser surgeries. We aim to test a non toxic, novel ophthalmic topical formulation developed to act on molecular and cellular targets of haze formation. The successful completion of the study will determine formulation’s optimal dose, safety and efficacy for its future potential clinical use in reversing corneal scarring/haze without side ef ....Presently, no drugs are proven to cure corneal haze/scarring, major leading cause of global blindness. Haze is caused by eye trauma, infections or refractive laser surgeries. We aim to test a non toxic, novel ophthalmic topical formulation developed to act on molecular and cellular targets of haze formation. The successful completion of the study will determine formulation’s optimal dose, safety and efficacy for its future potential clinical use in reversing corneal scarring/haze without side effects.Read moreRead less
THE ROLE OF MONOCYTIC LINEAGE CELLS IN MODELS OF CORNEAL DISEASE
Funder
National Health and Medical Research Council
Funding Amount
$311,567.00
Summary
Vision relies on sharp, focused undistorted images passing through the cornea, the clear 'window' at the front of the eye. Corneal disease causes over 5 million cases of blindness worldwide. In patients who damage the delicate covering of the cornea, due to trauma or contact lens wear, there is an increased risk of infection that may lead to blindness. This project will study the ways in which immune cells in the cornea detect invasion by potential pathogens.