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Role Of Microparticles In Cardiac Ischemia Reperfusion Injury
Funder
National Health and Medical Research Council
Funding Amount
$55,575.00
Summary
Interventional cardiology has reduced the mortality rate associated with heart attack, unfortunately the prevalence of heart failure has subsequently increased, caused in part by reperfusion injury of previously occluded vessels. We aim to identify novel insights into the pathogenesis of IR injury in the heart, as well as the development of new approaches to prevent cardiac damage during cardiac surgery, transplantation, post-angioplasty and coronary artery stenting.
Iron And Oxidative Stress In Stable And Unstable Coronary Artery Disease
Funder
National Health and Medical Research Council
Funding Amount
$86,570.00
Summary
This PhD investigates the key roles iron and insufficient antioxidants play in worsening tissue injury during and following a heart attack, in precipitating blockages in heart arteries, and in impairing blood vessel function in those with heart disease. By using drugs to remove iron from the body, it is possible to compare the detrimental effects of iron (on tissue injury and blood vessel function) in the group treated with the medication and the group treated with placebo.
Identification Of Mechanisms By Which Mesenchymal Stromal Cells Ameliorate Renal Ischaemia Reperfusion Injury
Funder
National Health and Medical Research Council
Funding Amount
$104,985.00
Summary
Acute kidney injury (AKI) is a common clinical entity which is associated with an increased risk of death and chronic kidney disease. Infusing adult mesenchymal stromal cells (cells which usually reside in the bone marrow but migrate to sites of inflammation or injury) has been shown to be beneficial in animal models of AKI, but it is not known how they have this effect. This project is designed to investigate the mechanism of action of mesenchymal stromal cells in AKI.
Pathophysiology Of Focal Human Entrapment Neuropathy
Funder
National Health and Medical Research Council
Funding Amount
$33,626.00
Summary
Neuropathy patients suffer from tingling, pain, numbness, spontaneous muscle contraction and cramp. The symptoms reflect abnormal activation of the nerve involved. It is known that an external agitation can worsen them, like in carpal tunnel syndrome (CTS). This study aims to investigate if changes in function of axonal membrane ion channel play any part in the symptoms. This will be done by comparing axonal membrane ion channel functions of healthy and CTS patients under external stimuli.