ARDC Research Link Australia

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $265,698.00
Summary: Damage to the heart from coronary vascular disease causes significant morbidity and mortality in Australia. Indeed, ischaemic injury represents the single greatest cause of premature death. Moreover, due to the increasing age of our population the problem is growing - coronary artery disease affects 50% of those older than 65, contributing to an increased incidence of angina pectoris, myocardial infarction, arrhythmia, congestive heart failure, and sudden death. Protective strategies have been, ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $496,302.00
Summary: Ischaemic heart disease is the leading cause of death in Australia, and will rise in coming years with the aging of our population. Our research shows aged hearts become less resistant to damage during ischaemia-heart attack, and insensitive to normally beneficial therapies. This project will identify molecular changes responsible for these changes. By understanding how age impairs the hearts defences, it may be possible to improve therapy of ischaemic heart disease in older patients.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $186,367.00
Summary: Heart disease and stroke are due to a narrowing of arteries followed by occlusion, due a combination of clot formation initiated by platelet clumping, and inflammation surrounding the vessel wall. The currently available drugs are often limited by the adverse reaction of bleeding. We will investigate the efficiency of a new drug to prevent clot formation and inflammation.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $271,786.00
Summary: Coronary artery disease remains the major cause of mortality for the adult population in our society. Despite the advances of coronary artery bypass surgery and medical treatment for reperfusion of occluded coronary arteries, the problem of impaired pump function of the heart remains a major obstacle. Although blood flow can be restored to the jeopardised heart muscle by either clot dissolving drugs, balloon angioplasty, or coronary artery surgery, the heart muscle may not regain pump function f ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $242,545.00
Summary: Heart transplantation has become established as an extremely beneficial treatment for patients with end-stage heart failure, however its success is limited by the restricted availability of donor hearts. Many hearts that could be considered for heart transplantation cannot be used because of damage that can occur to potential donor hearts after the death of the donor. This damage is caused in part by deterioration in heart function after death and in part by the process of removal and cold stora ....
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Funded Activity

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $470,250.00
Summary: Despite a decline in deaths rates due to heart disease over the last decade, cardiovascular disease remains the single greatest cause of premature death in individuals over 65 years of age. It accounts for a major and increasing portion of health care costs. Coronary artery disease affects 50% of those older than 65, and with the ageing of our population it is estimated that the elderly population will nearly double from 13-14% to 25% over the next 30 years. Unfortunately, it appears that the ag ....
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Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $86,570.00
Summary: This PhD investigates the key roles iron and insufficient antioxidants play in worsening tissue injury during and following a heart attack, in precipitating blockages in heart arteries, and in impairing blood vessel function in those with heart disease. By using drugs to remove iron from the body, it is possible to compare the detrimental effects of iron (on tissue injury and blood vessel function) in the group treated with the medication and the group treated with placebo.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $292,639.00
Summary: Heart disease is the leading cause of death and treatment options such as bypass surgery are unsuitable for many sufferers, particularly those with diabetes. This project investigates the regulation of new blood vessel growth through the action of antioxidants and also examines the contribution of adult stem cells to this process. Regulating new blood vessel growth provides a novel means to overcome current problems in the management of both non-diabetic and diabetic patients with heart disease.

Funded Activity

Funder: National Health and Medical Research Council
Funding Amount: $690,501.00
Summary: I am a cardiac pharmacologist investigating new therapies for the precursors of, and preventing their transition to, heart failure. My core activities focus on factors that control cardiac hypertrophy and ventricular function, in both the absence and pres

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