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Human Amnion Cells As A Therapy For Preterm Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$104,664.00
Summary
Premature babies often have serious breathing difficulties due to immature lungs, and these can remain life long. Amnion cells, which are from the membrane that surrounds the baby and placenta in the womb, behave like stem cells and can develop into lung cells. Using an animal model, we will give these cells to damaged premature lungs, and see if they can repair the lung tissue. We are hopeful this will improve the survival of premature babies and help prevent long term lung disease.
Molecular Characterisation Of Adiponectin Receptors: Implications For Adiponectin Action And Resistance
Funder
National Health and Medical Research Council
Funding Amount
$95,137.00
Summary
Adiponectin is a hormone secreted by fat cells with anti-inflammatory, anti-atherogenic and insulin sensitising properties. Adiponectin levels and actions are compromised in obesity and type 2 diabetes. Adponectin mediates its effects via two receptors but the mechanisms are poorly understood. This proposal aims to define the underlying mechanisms with the ultimate goal of identifying novel therapeutic strategies to improve adiponectin's actions.