Particle-stabilised bubble and droplet interfaces. Small particles may replace or supplement detergents in a broad range of applications. This project will provide the fundamental knowledge to optimise the use of particles to stabilise foams and emulsions in a controlled manner. This will transform economically important processes in the mining, food science or personal care industries.
Collection of coarse, composite particles by bubbles in flotation. The minerals industry is of great importance to the Australian economy and flotation is an essential process for the separation of base metals, non-sulphide minerals, and coal. Community benefits will come through lower energy and water consumption in mineral processing. The industry partners will benefit also through increased process efficiencies including increased recovery and lower costs, as well as an exposure to unique m ....Collection of coarse, composite particles by bubbles in flotation. The minerals industry is of great importance to the Australian economy and flotation is an essential process for the separation of base metals, non-sulphide minerals, and coal. Community benefits will come through lower energy and water consumption in mineral processing. The industry partners will benefit also through increased process efficiencies including increased recovery and lower costs, as well as an exposure to unique methodologies that will maintain their technological edge, and the potential to significantly increase their profitability by optimising their mineral processing operations. This project will contribute to the maintenance of a critical mass of research infrastructure at the partner organisations.Read moreRead less
Multi-functional probes for global analysis of proteome stress in cells. This project aims to create a suite of multi-functional chemical probes to identify damaged proteins that undergo unfolding or specific modifications in cells under stress. These probes will not only generate fluorescence responses to reflect on protein quality control capacity but allow associated proteins and their networks to be identified in complex cellular environments, which is difficult to achieve by current methods ....Multi-functional probes for global analysis of proteome stress in cells. This project aims to create a suite of multi-functional chemical probes to identify damaged proteins that undergo unfolding or specific modifications in cells under stress. These probes will not only generate fluorescence responses to reflect on protein quality control capacity but allow associated proteins and their networks to be identified in complex cellular environments, which is difficult to achieve by current methods. The expected outcome is to deliver new methodology for a comprehensive understanding of the correlation between quality control machinery, stress responses and cell functions. This should provide significant benefits, including contributing to fundamental knowledge on the molecular causes of neurodegenerative diseases.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE180100080
Funder
Australian Research Council
Funding Amount
$365,058.00
Summary
Examining lipid transport by direct visualisation and quantification. This project aims to investigate the least understood aspect of plasma triglyceride metabolism; mechanisms of transport across capillary endothelial cells. This transport regulates plasma triglyceride levels, which are an important factor in determining risk for coronary diseases. An improved understanding of these mechanisms will lead in the long term to better understandings of both heart failure and atherosclerotic heart di ....Examining lipid transport by direct visualisation and quantification. This project aims to investigate the least understood aspect of plasma triglyceride metabolism; mechanisms of transport across capillary endothelial cells. This transport regulates plasma triglyceride levels, which are an important factor in determining risk for coronary diseases. An improved understanding of these mechanisms will lead in the long term to better understandings of both heart failure and atherosclerotic heart diseases.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE170100058
Funder
Australian Research Council
Funding Amount
$372,000.00
Summary
Molecular reporters for measuring proteostasis capacity in cells. This project aims to develop fluorescent dyes to report on the change in unfolded protein load, which reflects the proteostasis status in real time in cells under stress conditions. Proteostasis is a housekeeping process cells undertake to maintain the proper folding and functions of proteins. Perturbation of proteostasis has been linked to neurodegenerative diseases, but chemical probes cannot measure the proteostasis capacity in ....Molecular reporters for measuring proteostasis capacity in cells. This project aims to develop fluorescent dyes to report on the change in unfolded protein load, which reflects the proteostasis status in real time in cells under stress conditions. Proteostasis is a housekeeping process cells undertake to maintain the proper folding and functions of proteins. Perturbation of proteostasis has been linked to neurodegenerative diseases, but chemical probes cannot measure the proteostasis capacity in cells. Intended outcomes include a mechanistic understanding of the relationship between protein misfolding, aggregation and proteostasis. This is expected to ultimately benefit the diagnosis of protein folding diseases, including dementia, and improve the quality of life.Read moreRead less
Dissecting a major sulfur cycling pathway: sulfoglycolysis. This project will elucidate the molecular details of sulfoglycolysis, a group of metabolic pathways through which the sulfur-containing sugar sulfoquinovose is catabolized. The project will employ an integrated metabolomic, chemical, biochemical and structural approach to dissect how various sulfoglycolytic organisms degrade sulfoquinovose. This project will deliver a deeper understanding of this major biochemical pathway and develop ne ....Dissecting a major sulfur cycling pathway: sulfoglycolysis. This project will elucidate the molecular details of sulfoglycolysis, a group of metabolic pathways through which the sulfur-containing sugar sulfoquinovose is catabolized. The project will employ an integrated metabolomic, chemical, biochemical and structural approach to dissect how various sulfoglycolytic organisms degrade sulfoquinovose. This project will deliver a deeper understanding of this major biochemical pathway and develop new chemical and metabolic approaches to manipulate sulfur cycling in the environment. Benefits will include biotechnology applications of newly discovered proteins, and sustainable approaches to reduce our dependence on agricultural fertilisers.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE120102687
Funder
Australian Research Council
Funding Amount
$375,000.00
Summary
Development of sensors for biological redox state. The plethora of antioxidant supplements on the market to prevent aging and disease highlights the great importance of oxidation state in the body. This project involves the development of chemical compounds that can be used to measure oxidation state in living tissue by Magnetic Resonance Imaging (MRI) or microscopy and help us understand various diseases.
Iron, ferroptosis and the biology of ageing. This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing by driving a newly discovered cell death program. Combining biology, chemistry and physics, this collaborative project aims to transform the understanding of the fundamental mechanisms of biological ageing. Anticipated outcomes include new assays for measuring iron in biology and identification of potential pathway ....Iron, ferroptosis and the biology of ageing. This project aims to determine how and when regulation of iron is lost. Failing iron metabolism during life may dictate the rate of ageing by driving a newly discovered cell death program. Combining biology, chemistry and physics, this collaborative project aims to transform the understanding of the fundamental mechanisms of biological ageing. Anticipated outcomes include new assays for measuring iron in biology and identification of potential pathways that regulate death signaling and lifespan. Outcomes will benefit life sciences and biotechnology industries.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE120100208
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
An advanced computational facility based on a graphic processing unit for particulate research. The graphic processing unit (GPU) is becoming an engine for the next generation of supercomputers for scientific research. The technology at this new facility will be exploited to perform large-scale, real time simulations of complex particulate material processing which is critical to Australia’s mineral/metallurgical/material industries.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE110100223
Funder
Australian Research Council
Funding Amount
$1,000,000.00
Summary
Advanced in-situ electron microscope facility for research in alloys, nanomaterials, functional materials, magnetic materials and minerals. This advanced in situ electron microscope facility will provide Australia with a new and critical capability to understand and design technologically important materials. It will enable advances in the areas of energy, environment, transport, construction and mining.