Transforming industrial waste into valuable carbons for iron-carbon alloys: Fundamental investigations of structure, impurity reactions and carbon dissolution. This project will deliver the comprehensive science that will enable the ferrous alloy industry to utilize industrial waste as a carbon resource. Novel recycling process will enhance the international competitiveness and environmental sustainability of Australian industries. At the same time, our advances will allow ferrous alloy producer ....Transforming industrial waste into valuable carbons for iron-carbon alloys: Fundamental investigations of structure, impurity reactions and carbon dissolution. This project will deliver the comprehensive science that will enable the ferrous alloy industry to utilize industrial waste as a carbon resource. Novel recycling process will enhance the international competitiveness and environmental sustainability of Australian industries. At the same time, our advances will allow ferrous alloy producers to consume substantial amounts of chemically inert, difficult to recycle industrial/composite waste, and significantly reduce the amount of waste being sent to landfills/illegal dumps. The technology will have a significant impact on the environment through reductions in greenhouse gas emissions, savings on raw materials and enhanced waste recycling. Read moreRead less
Transfer ribonucleic acid (tRNA) synthetases as drug targets in Plasmodium falciparum. Malaria is a major worldwide infectious disease. The disease kills around 2 million people every year, and current drugs are increasingly failing due to parasite drug resistance, creating an urgent demand for new drugs, that inhibit different targets. The Fellow will study a new class of parasite drug targets, the transfer ribonucleic acid (tRNA) synthetase enzymes to find novel inhibitors. Compounds blocking ....Transfer ribonucleic acid (tRNA) synthetases as drug targets in Plasmodium falciparum. Malaria is a major worldwide infectious disease. The disease kills around 2 million people every year, and current drugs are increasingly failing due to parasite drug resistance, creating an urgent demand for new drugs, that inhibit different targets. The Fellow will study a new class of parasite drug targets, the transfer ribonucleic acid (tRNA) synthetase enzymes to find novel inhibitors. Compounds blocking these enzymes may lead to new drugs to combat malaria.Read moreRead less
Discovery of new metabolic functions in Plasmodium parasites. This research will provide new understanding about the metabolism of parasites, such as those that cause malaria. These parasites have evolved bespoke metabolic networks to survive in diverse host environments including mosquitos and humans. Previous studies have revealed many unique genes and metabolites in these organisms, but their biochemical function is not known. This project will use state-of-the-art metabolomics and proteomics ....Discovery of new metabolic functions in Plasmodium parasites. This research will provide new understanding about the metabolism of parasites, such as those that cause malaria. These parasites have evolved bespoke metabolic networks to survive in diverse host environments including mosquitos and humans. Previous studies have revealed many unique genes and metabolites in these organisms, but their biochemical function is not known. This project will use state-of-the-art metabolomics and proteomics technology to accurately identify novel metabolites produced by the parasites, and discover the enzymes that are responsible for their synthesis. This work will not only advance our understanding of cellular metabolism, but will provide new opportunities for future biotechnology applications.Read moreRead less
Measuring mantle hydrogen to map ore fluids and model plate tectonics. The goal of this project is to use magnetotellurics to measure mantle hydrogen content to aid in the discovery of new mineral deposits. Hydrogen controls the strength of Earth’s mantle and is a vital component of the systems that form giant ore deposits. However, mantle hydrogen content is unconstrained. Ore-forming fluids hydrate the mantle pathways on which they travel. The first aim of this project is to image these fluid ....Measuring mantle hydrogen to map ore fluids and model plate tectonics. The goal of this project is to use magnetotellurics to measure mantle hydrogen content to aid in the discovery of new mineral deposits. Hydrogen controls the strength of Earth’s mantle and is a vital component of the systems that form giant ore deposits. However, mantle hydrogen content is unconstrained. Ore-forming fluids hydrate the mantle pathways on which they travel. The first aim of this project is to image these fluid pathways to improve mineral exploration techniques. Plate tectonic models assume that the lithospheric mantle is dehydrated but existing data from magnetotellurics and mantle rocks show high hydrogen contents. The second aim of this project is to create a map of the hydrogen content of the plates, which may lead to new models for continental evolution and mantle dynamics.Read moreRead less
Identifying the secular evolution of chemical heterogeneity in the mantle as probed by deep mantle plumes. This project aims to focus on modes and timescales of melting associated with deep mantle plumes. These melts form massive magmatic bodies and volcanic flood basalt provinces throughout Earth’s history and record the secular chemical evolution of the Earth’s mantle. Selective igneous bodies contain high-grade noble metal deposits and coincide with global mass extinction linked to anoxic oce ....Identifying the secular evolution of chemical heterogeneity in the mantle as probed by deep mantle plumes. This project aims to focus on modes and timescales of melting associated with deep mantle plumes. These melts form massive magmatic bodies and volcanic flood basalt provinces throughout Earth’s history and record the secular chemical evolution of the Earth’s mantle. Selective igneous bodies contain high-grade noble metal deposits and coincide with global mass extinction linked to anoxic ocean events in response to atmospheric volcanic pollution. This project aims to provide knowledge of planetary surface evolution in response to mantle dynamics, place constraints on enrichment processes of metals in ore quality in plume-derived melts, and may help understandings of the relation between massive volcanic eruptions and climate variability.Read moreRead less
Improving the Sustainability of Australian Livestock Production Systems. The sustainability of livestock production systems must urgently be improved. This Future Fellowship builds upon Dr Zamira Gibb's portfolio of high-impact research to deliver extension and adoption activities which will improve the outcomes of cattle and horse selective breeding programs; allowing the dissemination of low-methane genetics to remote Northern Australian cattle breeding regions, reducing wastage of breeding ho ....Improving the Sustainability of Australian Livestock Production Systems. The sustainability of livestock production systems must urgently be improved. This Future Fellowship builds upon Dr Zamira Gibb's portfolio of high-impact research to deliver extension and adoption activities which will improve the outcomes of cattle and horse selective breeding programs; allowing the dissemination of low-methane genetics to remote Northern Australian cattle breeding regions, reducing wastage of breeding horses and dairy cattle, and improving foal heath and offspring longevity. This project will address the environmental, ethical, and economic concerns which threaten the sustainability of these culturally significant livestock industries which are the cornerstone of everyday life in regional communities. Read moreRead less
Data-driven modelling of complex reactive flows. Complex reactive flow is dominant in many chemicals, physical and biological processes and should be optimised online for operational efficiency and stability, yet it is hindered by the lack of reliable model techniques. The project tackles this challenge by developing a next-generation data-driven modelling approach via integrating continuum/discrete-scale fluid-particle dynamics with system/control theories, supported by lab/plant experiments. D ....Data-driven modelling of complex reactive flows. Complex reactive flow is dominant in many chemicals, physical and biological processes and should be optimised online for operational efficiency and stability, yet it is hindered by the lack of reliable model techniques. The project tackles this challenge by developing a next-generation data-driven modelling approach via integrating continuum/discrete-scale fluid-particle dynamics with system/control theories, supported by lab/plant experiments. Driven by online data, the generic approach can open up a powerful way to reliably describe the inner state of reactors and online predict operation anomalies. The outcomes can help transform a range of industries to smart manufacturing and design, which is vital to Australia's technological future.Read moreRead less
Multi-functional probes for global analysis of proteome stress in cells. This project aims to create a suite of multi-functional chemical probes to identify damaged proteins that undergo unfolding or specific modifications in cells under stress. These probes will not only generate fluorescence responses to reflect on protein quality control capacity but allow associated proteins and their networks to be identified in complex cellular environments, which is difficult to achieve by current methods ....Multi-functional probes for global analysis of proteome stress in cells. This project aims to create a suite of multi-functional chemical probes to identify damaged proteins that undergo unfolding or specific modifications in cells under stress. These probes will not only generate fluorescence responses to reflect on protein quality control capacity but allow associated proteins and their networks to be identified in complex cellular environments, which is difficult to achieve by current methods. The expected outcome is to deliver new methodology for a comprehensive understanding of the correlation between quality control machinery, stress responses and cell functions. This should provide significant benefits, including contributing to fundamental knowledge on the molecular causes of neurodegenerative diseases.Read moreRead less
Uncovering a novel energy-sensing mechanism in the brain. This project aims to investigate a novel regulator of energy homeostasis in the brain, a protein kinase called SIK3. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This project intends to generate new knowledge about molecular switches to regulate energy homeostasis by using innovative gene technologies and transgenic animal models. The expected outcomes include generating fundament ....Uncovering a novel energy-sensing mechanism in the brain. This project aims to investigate a novel regulator of energy homeostasis in the brain, a protein kinase called SIK3. Energy homeostasis is essential for life as it ensures an adequate supply of fuel to cells of the body. This project intends to generate new knowledge about molecular switches to regulate energy homeostasis by using innovative gene technologies and transgenic animal models. The expected outcomes include generating fundamental insights into how SIK3 in the hypothalamic neurons regulates energy homeostasis. Benefits include improving population health and wellbeing, informing the development of new bio-medical technologies, and expanding the capabilities of Australia’s next generation of researchers.
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The microbe factory: a novel approach to benign minerals processing. The purpose of this project is to reduce the environmental impact of current mining practices. The anticipated outcome of this project is the replacement of toxic chemicals used in the separation of minerals with the novel use of environmentally benign microbes.