Role For Zinc And ZIP2 In The Action Of Nitric Oxide And In Vascular Protection Against Cigarette Smoke And Cardiovascular Disease
Funder
National Health and Medical Research Council
Funding Amount
$685,941.00
Summary
The NO/cGMP signalling pathway, which is central to cardiovascular physiology and protection against disease, is only fully effective when there are adequate levels of zinc in the vascular endothelium. This is especially important where zinc stores are depleted (elderly, smokers, diabetics and kidney disease). There is an urgent clinical need to implement strategies to monitor vascular Zn status. This application will explore the underlying science and translate these to the clinic.
Alveolar Macrophage Zinc And Zinc Transporters And Their Role In Phagocytosis
Funder
National Health and Medical Research Council
Funding Amount
$288,975.00
Summary
Zinc is an essential dietary component that serves a number of functions in the lungs. It is both an anti-oxidant and anti-inflammatory agent. Some airway inflammatory diseases such as emphysema may involve a critical loss of lung zinc. We believe that cigarette smoke causes the loss of zinc and this prevents the lung macrophages from working properly to clear bacteria and dead cells. This will provide a foundation for our long term goals of better clinical management of emphysema.
Airway Epithelial IAPs And Their Interaction With Zn Ions
Funder
National Health and Medical Research Council
Funding Amount
$260,779.00
Summary
The air we breathe contains a variety of harmful substances. Damage to the lining involves death of the ciliated cells that line the airways. We have shown that zinc protects these cells from premature death. This application focuses on a family of proteins called IAPs which bind zinc and regulate cell death in other tissues. This project focusses on how the IAPs and Zn may act together to mainitain healthy airways and how abnormalities of these may occur in people with asthma.
Role Of Zinc In The Respiratory Epithelium And Asthma
Funder
National Health and Medical Research Council
Funding Amount
$224,250.00
Summary
This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example ....This project will use a panel of Zinquin-derived Zn fluorophores developed in our laboratory, as well as probes for the mammalian family of vesicular ZnT transporters, to carry out a study of the normal physiology of Zn in the respiratory system and potential abnormalities of this in patients with chronic inflammatory respiratory disease (asthma, COPD, chronic smoking). Chronic inflammatory diseases of the respiratory tract affect a significant proportion of the Australian community. For example, asthma affects 12% of adults and amongst these, 15% waken weekly or more often with their asthma while 6% are hospitalized annually. There is a need to understand the basic mechanisms underlying these diseases so that new strategies can be developed to modify bronchocondtriction and inflammation. The project will provide new knowledge concerning the physiology of Zn in the respiratory epithelium and interactions between Zn deficiency and oxidants on injury in the respiratory tract. The usefulness of easily accessible nasal epithelial cells as a measure of Zn and Zn transporter levels deeper in the respiratory tract will be assessed. The project encompasses a number of fields and utilizes in vitro cellular and animal models, as well as tissues from human subjects.Read moreRead less
Industrial Transformation Training Centres - Grant ID: IC220100028
Funder
Australian Research Council
Funding Amount
$4,969,602.00
Summary
ARC Training Centre for Innovative Composites for the Future of Sustainable Mining Equipment. The Centre aims to train industry-focused researchers in advanced manufacturing of new-generation mining equipment and sustainable mining technology, through close collaborations among key universities and mining and manufacturing companies. The Centre will cultivate a team of world-class academic researchers and industry leaders to deliver an innovative program on research of innovative composites coup ....ARC Training Centre for Innovative Composites for the Future of Sustainable Mining Equipment. The Centre aims to train industry-focused researchers in advanced manufacturing of new-generation mining equipment and sustainable mining technology, through close collaborations among key universities and mining and manufacturing companies. The Centre will cultivate a team of world-class academic researchers and industry leaders to deliver an innovative program on research of innovative composites coupled with work-integrated learning, to not only produce a workforce that meets future skills demand but also develop sustainable and cost-effective mining equipment and high-efficiency mining technologies, benefiting the nation's manufacturing and mining sectors and significantly enhancing the competitiveness of the Australian mining industry.Read moreRead less
The Australasian Stress Map. The contemporary crustal stress field of Australasia is both more complex and more poorly constrained than that of other continental areas. The crustal stress field controls processes including earthquake hazard; the stability of mines, tunnels and boreholes, and; fluid flow in groundwater aquifers and oil reservoirs. Using data from oil exploration wells, earthquakes and recent geological activity, this project will increase from around 300 to 1000 the number of rel ....The Australasian Stress Map. The contemporary crustal stress field of Australasia is both more complex and more poorly constrained than that of other continental areas. The crustal stress field controls processes including earthquake hazard; the stability of mines, tunnels and boreholes, and; fluid flow in groundwater aquifers and oil reservoirs. Using data from oil exploration wells, earthquakes and recent geological activity, this project will increase from around 300 to 1000 the number of reliable stress determinations available for Australia, New Zealand and Papua New Guinea. The stress field will be modelled in order to improve our understanding of its origin and variability.Read moreRead less
The study and development of a 3D real-time stockpile management system. By successfully completing this project, the efficiency of existing infrastructure investments in industries involved in bulk material handling (inclusive of minerals, grain, sugar and woodchips) will be largely improved. This will allow such industries to contain costs and thus increase international competitiveness. Efficiencies gains (in these industries) to date have been in recover and processing with little attention ....The study and development of a 3D real-time stockpile management system. By successfully completing this project, the efficiency of existing infrastructure investments in industries involved in bulk material handling (inclusive of minerals, grain, sugar and woodchips) will be largely improved. This will allow such industries to contain costs and thus increase international competitiveness. Efficiencies gains (in these industries) to date have been in recover and processing with little attention to stockyard and movement within the stockyards. The industries sectors in which will receive the greatest benefits are in rural and remote Australia. There is also the ability of the system to be exported to overseas clients, particularly in the mining sector.Read moreRead less
Cluster hardening of metastable steel alloys produced by thin strip casting. The goal of this project is to generate sufficient knowledge to apply strip casting to a wider range of steel grades and reduce the global energy cost of steel sheet production. Over 1 billion tonnes of steel is produced every year. Direct strip casting is an emerging green technology that reduces the energy required to process liquid steel into thin sheet product by up to 90 per cent. This study plans to use advanced a ....Cluster hardening of metastable steel alloys produced by thin strip casting. The goal of this project is to generate sufficient knowledge to apply strip casting to a wider range of steel grades and reduce the global energy cost of steel sheet production. Over 1 billion tonnes of steel is produced every year. Direct strip casting is an emerging green technology that reduces the energy required to process liquid steel into thin sheet product by up to 90 per cent. This study plans to use advanced atomic-scale characterisation techniques such as atom probe tomography and high-resolution electron microscopy to understand the non-equilibrium microstructures that develop as a result of the extremely rapid cooling rates experienced during strip casting.Read moreRead less
Measuring mantle hydrogen to map ore fluids and model plate tectonics. The goal of this project is to use magnetotellurics to measure mantle hydrogen content to aid in the discovery of new mineral deposits. Hydrogen controls the strength of Earth’s mantle and is a vital component of the systems that form giant ore deposits. However, mantle hydrogen content is unconstrained. Ore-forming fluids hydrate the mantle pathways on which they travel. The first aim of this project is to image these fluid ....Measuring mantle hydrogen to map ore fluids and model plate tectonics. The goal of this project is to use magnetotellurics to measure mantle hydrogen content to aid in the discovery of new mineral deposits. Hydrogen controls the strength of Earth’s mantle and is a vital component of the systems that form giant ore deposits. However, mantle hydrogen content is unconstrained. Ore-forming fluids hydrate the mantle pathways on which they travel. The first aim of this project is to image these fluid pathways to improve mineral exploration techniques. Plate tectonic models assume that the lithospheric mantle is dehydrated but existing data from magnetotellurics and mantle rocks show high hydrogen contents. The second aim of this project is to create a map of the hydrogen content of the plates, which may lead to new models for continental evolution and mantle dynamics.Read moreRead less
A new damage model for rock burst in hard rocks during deep mining. This project seeks to develop a new model to predict incipient rock burst in deep mines. Violent sudden energy released during dynamic brittle failure of rocks can kill people and cause serious damages to mining infrastructures. The project aims to investigate formation of micro-fractures on the brittle shear zones during dynamic brittle failure of pristine rocks with a unique experimental methodology under high-pressure-tempera ....A new damage model for rock burst in hard rocks during deep mining. This project seeks to develop a new model to predict incipient rock burst in deep mines. Violent sudden energy released during dynamic brittle failure of rocks can kill people and cause serious damages to mining infrastructures. The project aims to investigate formation of micro-fractures on the brittle shear zones during dynamic brittle failure of pristine rocks with a unique experimental methodology under high-pressure-temperature condition. It is anticipated that a new micromechanics-based damage model for brittle rocks will be developed from this. Implementation of the new coupled thermo-mechanical damage model into a finite element should result in realistic simulation of deep mining operations to identify rock-burst prone areas and allow mining managers to avoid potential hazards.Read moreRead less