Immunising Aboriginal Mothers With Pneumococcal Polysaccharide Vaccine To Prevent Infant Ear Disease And Carriage
Funder
National Health and Medical Research Council
Funding Amount
$1,131,530.00
Summary
Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are nee ....Aboriginal children experience the highest rates of acute and chronic ear infections in the world, with resultant permanent ear damage, hearing loss and educational disadvantage. These infections are mainly bacterial, and Streptococcus pneumoniae (pneumococcus) is the predominant pathogen. Pneumococcal colonisation and infection begins within days of birth, many months before any potential immunological protection from infant pneumococcal conjugate vaccine may be expected. New strategies are needed to eliminate, or at least delay, this early-onset pneumococcal colonisation. One such strategy is the administration to the mother of pneumococcal vaccine, which may protect the newborn infant by leading to higher titres of transplacental or breast milk pneumococcal antibodies and-or by reducing carriage (and transmission to the infant) of maternal pneumococci. Previous small studies using this strategy have been encouraging, but there have been no studies properly evaluating carriage or disease endpoints in infants. The polysaccharide pneumococcal vaccine is currently recommended for all Aboriginal and Torres Islander persons aged 15 years or more in the Northern Territory but uptake of the vaccine has been poor. We propose to conduct a pilot study to determine if maternal immunisation with this vaccine, either in the third trimester of pregancy of immediately following delivery, can reduce pneumococcal carriage and the prevalence of middle ear disease among Aboriginal infants at seven months of age. We aim to recruit 210 Aboriginal women who have uncomplicated pregnancies from Darwin and remote communities in the Top End of the Northern Territory. Each subject and their infant offspring will be followed-up after vaccination and at birth, one , two and seven months after birth.Read moreRead less
Synchrotron X-ray Assessment Of Airway Surface Physiology For Cystic Fibrosis
Funder
National Health and Medical Research Council
Funding Amount
$778,228.00
Summary
We seek a cure or long-lasting therapy for the fatal airway disease in cystic fibrosis. Disease is caused by a shallow and dehydrated airway surface liquid (ASL), allowing bacteria to infect the lung. We can introduce a corrective gene into mouse airways where it can be effective for over 1 yr, but no fast, accurate and non-invasive measurement exists to test if treatments are successful. We will develop methods using synchrotron light to directly measure ASL depth changes in live mouse airways.
A Study To Investigate Alternative Regimens For Pneumococcal Vaccination Of Infants In A Developing Country
Funder
National Health and Medical Research Council
Funding Amount
$1,622,210.00
Summary
Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver thi ....Streptococcus pneumoniae (Pnc) is the leading vaccine preventable cause of serious infection in infants. The current Pnc conjugate vaccine is very expensive (approximately USD $200-infant) so it is unlikely to be affordable for most developing countries. Moreover, as health care access in developing countries may be episodic and unreliable, many children do not receive either complete or timely vaccine courses. Therefore, it is important to investigate affordable and flexible ways to deliver this vaccine, which are safe and effective. A recent WHO-GAVI meeting to address impediments to the introduction of these vaccines in developing countries recognized the need to evaluate other regimens of Pnc conjugate vaccine as an important research priority. This study has been deliberately formulated with that need in mind. The site for this research is Fiji. Although health services are good, Pnc disease, particularly pneumonia, remains the commonest cause of childhood morbidity and mortality. Fiji has good vaccine coverage and was the first Pacific country to introduce Hib vaccine. The arrival of the new, expensive Pnc conjugate vaccine presents a dilemma for Fiji and many similar countries. The expense of this vaccine would consume a large portion of the health budget. This study has two components: 1. A Phase 2 immunogenicity study (involving 750 infants) to evaluate regimens using reduced numbers of doses of Pnc conjugate vaccine, and using timing of dosing and combinations with the Pnc polysaccharide (PS) vaccine that may be more suited to the epidemiology of Pnc disease in developing countries. 2. An epidemiological study will measure the burden of invasive Pnc disease and pneumonia in Fiji. This will be part of a global effort to address these issues, and will be used to develop rapid assessment tools for these diseases in developing countries. We will seek cofounding for this component.Read moreRead less
'Streamlining search and destroy': development of a robust prioritisation framework for weed eradication using Hawkweed species. Introduced species are one of the greatest threats to our biodiversity and agriculture, as evidenced by the ARC’s National Research Priority: Safeguarding Australia. This project will advance Australia’s ability to protect itself from invaders by developing tools that guide cost-effective detection and response. Our project will have a direct effect on the planning a ....'Streamlining search and destroy': development of a robust prioritisation framework for weed eradication using Hawkweed species. Introduced species are one of the greatest threats to our biodiversity and agriculture, as evidenced by the ARC’s National Research Priority: Safeguarding Australia. This project will advance Australia’s ability to protect itself from invaders by developing tools that guide cost-effective detection and response. Our project will have a direct effect on the planning and management of Hawkweed control in Victoria and New South Wales. The framework delivered will have direct application to numerous other weeds (and relevance to other pests and diseases) within and beyond Australia. Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100257
Funder
Australian Research Council
Funding Amount
$446,857.00
Summary
Molecular biosecurity: Genomic databanks for managing new pest invasions. This project aims to develop a set of genomics-based approaches for analysing new pest invasions. By producing and analysing genomic databanks for four insect pest species, including three that have recently invaded Australia, this project expects to identify invasion origins and to track new pest incursions within Australia. The project should also provide insights into pest ecology, including movement rates and populatio ....Molecular biosecurity: Genomic databanks for managing new pest invasions. This project aims to develop a set of genomics-based approaches for analysing new pest invasions. By producing and analysing genomic databanks for four insect pest species, including three that have recently invaded Australia, this project expects to identify invasion origins and to track new pest incursions within Australia. The project should also provide insights into pest ecology, including movement rates and population change over time. This information can enable more efficient deployment of biosecurity resources and pave the way for genomics to be used pre-emptively to stop new invasions. This can help make genomics a go-to response to new pest invasions and position Australia at the forefront of genomics-based pest biosecurity.Read moreRead less
Using guardian dogs to protect threatened species. This project explores whether guardian dogs can be used to reduce predation on threatened native wildlife. Guardian dogs are ancient breeds of dogs that live with livestock and protect them from wild predators. The project aims to measure the impacts of guardian dogs on distribution and behaviour of feral cats and red foxes, and monitor trial reintroductions of eastern barred bandicoots in the presence of guardian dogs. It aims to provide an inn ....Using guardian dogs to protect threatened species. This project explores whether guardian dogs can be used to reduce predation on threatened native wildlife. Guardian dogs are ancient breeds of dogs that live with livestock and protect them from wild predators. The project aims to measure the impacts of guardian dogs on distribution and behaviour of feral cats and red foxes, and monitor trial reintroductions of eastern barred bandicoots in the presence of guardian dogs. It aims to provide an innovative solution to one of Australia's most significant conservation problems: the persistent failure of attempts to reintroduce threatened species to open landscapes with invasive predators.Read moreRead less
Eco-evolutionary drivers of niche dynamics in invasive weeds. The project aims to understand how and why invasive species become invasive. Many exotic species are known to expand their ecological niches in their novel range, exploiting habitats that ancestral populations never used. Using a unique approach that combines field transplant and quantitative genetics experiments, this study will identify the drivers of niche expansion in invasive Australian capeweed, and predict if the invasive popul ....Eco-evolutionary drivers of niche dynamics in invasive weeds. The project aims to understand how and why invasive species become invasive. Many exotic species are known to expand their ecological niches in their novel range, exploiting habitats that ancestral populations never used. Using a unique approach that combines field transplant and quantitative genetics experiments, this study will identify the drivers of niche expansion in invasive Australian capeweed, and predict if the invasive populations are likely to further expand their niches. By delivering key insights into mechanisms of adaptive evolution in invasive species, this research should benefit efforts to effectively limit the spread of invasive plants that threaten the native environment. Read moreRead less
Interactions among invading species: transient hybridisation and rates of replacement. Habitats are often invaded sequentially by multiple species. Interactions between these invaders can potentially alter their rates of spread and eventual distributions. This project will combine experimental research and modelling to test specific hypotheses about the processes occurring as one species arrives in a region already containing a close relative and proceeds to replace it. It will use two sea rock ....Interactions among invading species: transient hybridisation and rates of replacement. Habitats are often invaded sequentially by multiple species. Interactions between these invaders can potentially alter their rates of spread and eventual distributions. This project will combine experimental research and modelling to test specific hypotheses about the processes occurring as one species arrives in a region already containing a close relative and proceeds to replace it. It will use two sea rockets (Cakile sp.) currently invading Australia’s coastline is its focus. By determining the importance of such species interactions, the research will contribute to the development of better estimates of invasive species impacts, thereby improving decisions on their management.Read moreRead less
New metrics to measure and track fauna community condition in Australia. This project aims to improve how biodiversity is measured by developing a system to describe the condition of animal communities, analogous to those used for plant communities. It develops and tests the system for Australia’s birds, then extends the approach to other animal groups. The project expects to develop a data-driven typology of bird communities, accompanying community condition metrics that are scalable from site ....New metrics to measure and track fauna community condition in Australia. This project aims to improve how biodiversity is measured by developing a system to describe the condition of animal communities, analogous to those used for plant communities. It develops and tests the system for Australia’s birds, then extends the approach to other animal groups. The project expects to develop a data-driven typology of bird communities, accompanying community condition metrics that are scalable from site to national levels, and guidance for using these metrics in practice. These metrics will enable holistic and relevant measures of the biodiversity value of sites, improve evaluation of restoration actions, reveal trends in community condition, and inform monitoring and evaluation tools for emerging biodiversity markets.Read moreRead less
Horizontal ecological networks for understanding biodiversity maintenance. The project aims to develop new ecological theory on local diversity maintenance based on an innovative interaction network model, tested on Western Australian wildflower communities. It is novel in its focus on the complexity of species interactions and their importance to diversity maintenance in nature. This project aims to explore links between plant interaction networks and coexistence theory to provide theoretical e ....Horizontal ecological networks for understanding biodiversity maintenance. The project aims to develop new ecological theory on local diversity maintenance based on an innovative interaction network model, tested on Western Australian wildflower communities. It is novel in its focus on the complexity of species interactions and their importance to diversity maintenance in nature. This project aims to explore links between plant interaction networks and coexistence theory to provide theoretical expectations for how changes to the environment are expected to alter natural plant communities. It aims to fill theory-gap about mechanisms of multi-species coexistence, advance community ecology, and provide the theoretical foundations necessary for translating ecological theory to restoration and conservation in practice.Read moreRead less