Diseases caused by the pneumococcus represent the largest cause of vaccine preventable death in the world today, mainly pneumonia and meningitis. In 2011, 16 developing countries will introduce pneumococcal conjugate vaccines, none in east Asia. Lack of research has been a major barrier to their use in the region. We have established an international centre of excellence in the field and we seek support to extend the capacity of this group and to transfer the technology to Vietnam.
Impact Of DTP Schedules On The Immunogenicity Of 2 Doses Of 13v-PCV Followed By An Early Booster
Funder
National Health and Medical Research Council
Funding Amount
$2,651,687.00
Summary
This project aims to come up with a vaccination schedule to make pneumococcal vaccines more effective and affordable for Fiji and other developing countries. We will evaluate schedules involving a 2 dose primary series in early infancy with a booster at 9 months of age. We will compare the immune responses to 3 different primary series and 2 booster options. The results of this project will be used to provide advice, at global and country levels, regarding introduction of pneumococcal vaccines.
Understanding The Role Of The Two Major Bacterial Pathogens In The Upper And Lower Airways Of Indigenous Children With Chronic Lung Disease
Funder
National Health and Medical Research Council
Funding Amount
$743,282.00
Summary
Lung infections are a major disease burden worldwide. Indigenous Australians are affected more; adults with severe lung disease can die in their 30s and 40s. These diseases start early, yet no in-depth studies of bacteria causing lung infections in children have been done. Our expert team proposes to use existing lung fluids from nearly 500 children with chronic lung disease (58% Indigenous), and state-of-the-art laboratory methods, to inform the design of vaccines to prevent lung disease.
PrtFII, A Streptococcus Pyogenes Fibronectin Binding Protein, And Invasive Diseases.
Funder
National Health and Medical Research Council
Funding Amount
$296,540.00
Summary
Our recent work revealed that, in the Aboriginal population, young age is a risk factor for severe invasive diseases caused by group A streptococcus. For group A streptococcus infection to occur, bacterial attachment is the first step. The bacterium attaches to host cells through interactions involving host fibronectin and the pathogen's fibronectin-binding proteins. We have found that streptococcal strains from severe disease cases are more likely to have the gene for PrtFII, a fibronectin bind ....Our recent work revealed that, in the Aboriginal population, young age is a risk factor for severe invasive diseases caused by group A streptococcus. For group A streptococcus infection to occur, bacterial attachment is the first step. The bacterium attaches to host cells through interactions involving host fibronectin and the pathogen's fibronectin-binding proteins. We have found that streptococcal strains from severe disease cases are more likely to have the gene for PrtFII, a fibronectin binding protein, than those from uncomplicated skin sores. In this application we propose to extend this observation and compare biochemical properties of PrtFII from strains belonging to the above two sets of collections. We hypothesise that PrtFII from invasive strains bind to fibronectin more tightly than the proteins from strains that cause uncomplicated infection. We also will test whether sera from invasive disease cases have lower titre of antibodies to the conserved region of PrtFII than sera from uncomplicated cases. A streptococcal vaccine by necessity has to be a multi-component vaccine to cover a wide spectrum of diseases and epidemiological differences. The study proposed here may provide a basis to argue whether or not to include PrtFII in such a multi-component vaccine.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE230100373
Funder
Australian Research Council
Funding Amount
$447,320.00
Summary
The role of resource fluctuations in structuring microbial communities. The flow of nutrients through ecological systems fluctuates through time and yet the impact this variability has on the maintenance of biodiversity is poorly understood. Drawing on emerging theory and a tight integration of modelling and experiments in a model microbial system, this project aims to investigate the impact of modified nutrient regimes on the structure and stability of ecological communities. This project expec ....The role of resource fluctuations in structuring microbial communities. The flow of nutrients through ecological systems fluctuates through time and yet the impact this variability has on the maintenance of biodiversity is poorly understood. Drawing on emerging theory and a tight integration of modelling and experiments in a model microbial system, this project aims to investigate the impact of modified nutrient regimes on the structure and stability of ecological communities. This project expects to generate new knowledge at the forefront of research into diversity maintenance, ecosystem functioning and higher-order interactions. The outcomes should provide a deep mechanistic understanding of microbial community dynamics, with applications from animal health to environmental flows and insect pest management.Read moreRead less
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE240100006
Funder
Australian Research Council
Funding Amount
$350,000.00
Summary
Northern Australia Plant Biosecurity Facility. Quarantine glasshouses (Biosecurity Containment Level 2) are required to develop research with invasive plants. However, in Australia, no quarantine glasshouses exist north of parallel 27 (Brisbane), posing a remarkable barrier to research on tropical biosecurity. This proposal aims to establish a quarantine glasshouse for a broad range of internal and external users, enabling scientists based in the Australian tropics and other interested parties t ....Northern Australia Plant Biosecurity Facility. Quarantine glasshouses (Biosecurity Containment Level 2) are required to develop research with invasive plants. However, in Australia, no quarantine glasshouses exist north of parallel 27 (Brisbane), posing a remarkable barrier to research on tropical biosecurity. This proposal aims to establish a quarantine glasshouse for a broad range of internal and external users, enabling scientists based in the Australian tropics and other interested parties to address plant biosecurity risks from and for northern Australia. Tropical biosecurity is a key area of strategic focus for JCU and its network of partners, who will benefit from the targeted research, quarantine services, and specialized training that will be enabled by this facility.Read moreRead less
Understanding population growth time lags in invasive species. This project will use data collected from wild animals, landholder surveys, and computer simulation models to understand why invasive chital deer (Axis axis) are suddenly increasing in number after many years of slow population growth. By combining multiple empirical datasets and developing new modelling techniques, we will generate a new method for understanding population trends in introduced species. The results of this study will ....Understanding population growth time lags in invasive species. This project will use data collected from wild animals, landholder surveys, and computer simulation models to understand why invasive chital deer (Axis axis) are suddenly increasing in number after many years of slow population growth. By combining multiple empirical datasets and developing new modelling techniques, we will generate a new method for understanding population trends in introduced species. The results of this study will allow Queensland Department of Agriculture and Fisheries and others to better predict invasive species growth rates, which will allow for better, and more cost effective control methods. Read moreRead less
New metrics to measure and track fauna community condition in Australia. This project aims to improve how biodiversity is measured by developing a system to describe the condition of animal communities, analogous to those used for plant communities. It develops and tests the system for Australia’s birds, then extends the approach to other animal groups. The project expects to develop a data-driven typology of bird communities, accompanying community condition metrics that are scalable from site ....New metrics to measure and track fauna community condition in Australia. This project aims to improve how biodiversity is measured by developing a system to describe the condition of animal communities, analogous to those used for plant communities. It develops and tests the system for Australia’s birds, then extends the approach to other animal groups. The project expects to develop a data-driven typology of bird communities, accompanying community condition metrics that are scalable from site to national levels, and guidance for using these metrics in practice. These metrics will enable holistic and relevant measures of the biodiversity value of sites, improve evaluation of restoration actions, reveal trends in community condition, and inform monitoring and evaluation tools for emerging biodiversity markets.Read moreRead less
Horizontal ecological networks for understanding biodiversity maintenance. The project aims to develop new ecological theory on local diversity maintenance based on an innovative interaction network model, tested on Western Australian wildflower communities. It is novel in its focus on the complexity of species interactions and their importance to diversity maintenance in nature. This project aims to explore links between plant interaction networks and coexistence theory to provide theoretical e ....Horizontal ecological networks for understanding biodiversity maintenance. The project aims to develop new ecological theory on local diversity maintenance based on an innovative interaction network model, tested on Western Australian wildflower communities. It is novel in its focus on the complexity of species interactions and their importance to diversity maintenance in nature. This project aims to explore links between plant interaction networks and coexistence theory to provide theoretical expectations for how changes to the environment are expected to alter natural plant communities. It aims to fill theory-gap about mechanisms of multi-species coexistence, advance community ecology, and provide the theoretical foundations necessary for translating ecological theory to restoration and conservation in practice.Read moreRead less
How positive interactions improve predictions of plant community diversity. Though common in nature, the importance of plant-plant facilitation to coexistence and the maintenance of plant diversity at community scales is poorly understood. This project aims to advance understanding of how positive interactions (facilitation) impact on coexistence among plant species as well as local patterns of diversity. To achieve these aims the project will use a combination of field experiments and a compara ....How positive interactions improve predictions of plant community diversity. Though common in nature, the importance of plant-plant facilitation to coexistence and the maintenance of plant diversity at community scales is poorly understood. This project aims to advance understanding of how positive interactions (facilitation) impact on coexistence among plant species as well as local patterns of diversity. To achieve these aims the project will use a combination of field experiments and a comparative analysis of competition and facilitation in Australian, Californian and Spanish annual plant communities with a novel modelling approach for predicting coexistence across variable environments. Outcomes are expected to include an innovative predictive framework of use for plant conservation in Australia and beyond.Read moreRead less