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Examining The Intracellular Pathways Regulated By GM-CSF In Macrophages And The Role In Diseases Such Arthritis.
Funder
National Health and Medical Research Council
Funding Amount
$63,567.00
Summary
A protein, termed GM-CSF, has been shown to be important in inflammatory conditions, like rheumatoid arthritis. GM-CSF can modify the properties of a key white blood cell, the macrophage, causing macrophages to produce factors harmful to host tissue. Various therapies are being developed to block GM-CSF, however discovering other drugs that block the intracellular actions of GM-CSF in macrophages are needed. Therefore the molecular pathways governing these actions need to be defined.
Enhancement Of The Anti-tumour Efficacy Of Ionising Radiation Through Inhibition Of Phosphoinositide 3-kinase
Funder
National Health and Medical Research Council
Funding Amount
$123,503.00
Summary
Radiation treatment alone is given to many cancer patients, however often it does not prevent cancers from recurring. Significant promise is offered by new drugs that target molecules which play a key role in cancer growth, and combining these drugs with radiation treatment may lead to improved patient outcomes. Understanding how these drugs enhance the anti-cancer effects of radiation is critical to selecting the most appropriate patients for treatment with this combination.
Transient Receptor Potential Calcium Channels In Breast Cancer Cell Proliferation, Apoptosis And Invasiveness
Funder
National Health and Medical Research Council
Funding Amount
$104,018.00
Summary
Calcium is a highly regulated signal used by cells to control processes such as growth and division, cell death and motility. Calcium channels let calcium into the cells, and specific calcium channel types are overexpressed in cancers, including those of the prostate and breast. In this research, we will assess the role of specific calcium permeable channels known as TRPs in breast cancer and the consequences of their inhibition on breast cancer cell growth and survival.