Preclinical Development Of A Therapeutic Anticancer Antibody To C-Met
Funder
National Health and Medical Research Council
Funding Amount
$435,530.00
Summary
Many common cancers cannot be effectively treated. A range of these cancers (e.g. gastric and lung cancer) display the molecule c-Met on their cell surface. c-Met promotes tumour growth; therefore, blocking c-Met is a promising strategy for treating these cancers. However, no antibodies or drugs that target c-Met have been licensed. The therapeutics that are being developed to target c-Met all have considerable limitations. Thus, there is an opportunity to develop a 'best-in-class' therapeutic.
Reducing Peer Victimisation In Australian Schools Through Targeted And Universal Approaches
Funder
National Health and Medical Research Council
Funding Amount
$1,063,531.00
Summary
Peer victimisation is a significant problem for young people in Australia and can lead to devastating long-term consequences including poor self esteem, depression and suicide. The current project aims to identify the most cost effective methods to reduce peer victimisation in schools. This will combine programs applied across the whole school with a more targeted program building resilience in vulnerable children. The results will have important implications for anti-bullying policies in school ....Peer victimisation is a significant problem for young people in Australia and can lead to devastating long-term consequences including poor self esteem, depression and suicide. The current project aims to identify the most cost effective methods to reduce peer victimisation in schools. This will combine programs applied across the whole school with a more targeted program building resilience in vulnerable children. The results will have important implications for anti-bullying policies in schools.Read moreRead less
Using Total Population Data To Describe The Characteristics Of Respiratory Infections In Order To Predict Future Epidemics And Recommend Vaccination Strategies For Western Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$294,892.00
Summary
Respiratory infections are a major reason for children to go to hospital. I am an epidemiologist and I will be using previously collected and linked laboratory and hospital data from Western Australian children to better understand how these infections flow through the population over different seasons. I will then be able to predict future epidemics of respiratory infections and how different vaccine programs might have an impact in reducing how many children are affected by these infections.
Vaccination Timeliness In Aboriginal And Non-Aboriginal Infants: Risk Factors For Delayed Vaccination And Impact On Disease Burden—a Record Linkage Study
Funder
National Health and Medical Research Council
Funding Amount
$538,183.00
Summary
Vaccination has had a significant impact, but preventable infections continue to occur, perhaps due to delayed uptake of scheduled doses. For the first time, we will link vaccination and other health records to: provide accurate estimates of the impact of vaccination; identify reasons for delayed vaccination; and quantify the expected reduction in disease burden if vaccination timeliness was improved. The study will help determine who would benefit most from efforts to improve timeliness.
Innovative School-based Interventions To Improve Mental Health And The Social And Emotional Development Of Australian Children
Funder
National Health and Medical Research Council
Funding Amount
$763,845.00
Summary
I am a Professor in the Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia and the Telethon Kids Institute. My research develops and delivers interventions that improve the quality of life, health, education, safety and social justice outcomes for Australian children. My work is particularly focused on ways to reduce harms from bullying and cyberbullying among children and adolescents.
Digital China: From cultural presence to innovative nation. This project aims to investigate how digital platforms and technologies help Chinese culture and ideas reach the world. While China's global cultural presence has increased, it is not seen as an innovative nation. The project examines how the Chinese government’s internet+ strategy changes power dynamics among political institutions, commercially motivated digital companies and online communities. The project will investigate internatio ....Digital China: From cultural presence to innovative nation. This project aims to investigate how digital platforms and technologies help Chinese culture and ideas reach the world. While China's global cultural presence has increased, it is not seen as an innovative nation. The project examines how the Chinese government’s internet+ strategy changes power dynamics among political institutions, commercially motivated digital companies and online communities. The project will investigate internationalisation strategies and consumption of Chinese culture on digital platforms in China, Australia, Hong Kong, Singapore and South Korea. It expects to understand the implications of China's digital ascendency and the lessons for Australia in the post-resources boom era.Read moreRead less
The Impact Of Therapy On T-cell Recognition Of Mutated Tumour Neo-antigens
Funder
National Health and Medical Research Council
Funding Amount
$1,126,685.00
Summary
Cancer is caused by mutations which should be 'seen' and destroyed by the patients immune cells, similar to how immune cells protect us against viruses. But they don't. This grant will study how current cancer treatments help the immune cells 'see' these mutations. We will undertake these studies in the important cancers lung cancer and mesothelioma.
A Study Of Artemisinin Combination Therapy Given At Delivery To Prevent Postpartum Malaria And To Young Infants To Treat Uncomplicated Malaria
Funder
National Health and Medical Research Council
Funding Amount
$788,850.00
Summary
The proposed studies will investigate the preventive value of a course of combination antimalarial treatment at delivery in pregnant women in malarial areas. The transfer of this treatment into breast milk and to the suckling infant will be investigated since this may protect the infant against malaria but also cause drug-related side-effects. These data will be used, with a study of combination treatment in infants with malaria, to optimise dose regimens in this vulnerable group.
Improving Stroke Outcomes: Attenuating Progression And Recurrence
Funder
National Health and Medical Research Council
Funding Amount
$9,331,996.00
Summary
Stroke is the second most common cause of death and major cause disability. There are few proven interventions, so we need to introduce new ones. We developed a bench to bedside program to introduce new stroke therapies and its early secondary prevention. Our general goal is to provide evidence for their effectiveness and safety. We will use animal stroke models, markers in the blood to help diagnose and predict stroke outcome and imaging to help select patients for several clinical trials.
Designing for uncertainty in conservation auctions. Economic theory and case study evidence show that tenders or auctions are more efficient than grant mechanisms for encouraging landholders to produce environmental outcomes on private land. These studies have ignored the effects of uncertainty of both bidders and administrators about factors such as landholder participation and the level of environmental benefits that will be delivered. This project will test whether distributing environmental ....Designing for uncertainty in conservation auctions. Economic theory and case study evidence show that tenders or auctions are more efficient than grant mechanisms for encouraging landholders to produce environmental outcomes on private land. These studies have ignored the effects of uncertainty of both bidders and administrators about factors such as landholder participation and the level of environmental benefits that will be delivered. This project will test whether distributing environmental funds via tenders is still efficient when uncertainty about various important factors is considered. Results from this research are expected to inform the cost effective design of systems to pay landholders for the provision of environmental benefits even when there is high uncertainty.Read moreRead less