The Effectiveness Of A Comprehensive ‘universal’ And ‘targeted’ Intervention To Prevent Substance Use And Related Harms In Adolescents: The CAP Project
Funder
National Health and Medical Research Council
Funding Amount
$755,906.00
Summary
Alcohol and other drug use are common amongst Australian adolescents and the disability associated with this use is considerable. Prevention is clearly needed, yet we have few models of well implemented prevention programs that are effective in maximisising prevention outcomes.The current proposal addresses this gap by evaluating a novel approach to preventing substance use and related harms in adolescents by combining effective 'universal' and 'targeted' school-based prevention programs in a su ....Alcohol and other drug use are common amongst Australian adolescents and the disability associated with this use is considerable. Prevention is clearly needed, yet we have few models of well implemented prevention programs that are effective in maximisising prevention outcomes.The current proposal addresses this gap by evaluating a novel approach to preventing substance use and related harms in adolescents by combining effective 'universal' and 'targeted' school-based prevention programs in a sustainable delivery platform.Read moreRead less
WEB-BASED COGNITIVE BEHAVIOURAL THERAPY FOR WOMEN WITH POSTNATAL DEPRESSION
Funder
National Health and Medical Research Council
Funding Amount
$713,714.00
Summary
Postnatal depression (PND) affects more than 1 in 10 women, with serious consequences for maternal mental health and infant development. This project will evaluate our newly developed Web-based psychological intervention for PND and compare it to traditional face-to-face psychological treatment. Poor uptake of traditional treatment relates to fear of stigma, access and expense. The potential public health impact of Web-based treatment is enormous given the 300,000 annual births in Australia.
Finding My Way: A Randomised Controlled Trial Evaluating An Internet Self-help Program For Cancer-related Distress
Funder
National Health and Medical Research Council
Funding Amount
$392,608.00
Summary
The internet is increasingly utilised by people affected by cancer to obtain information and support. However, to date no randomised controlled study has evaluated the effectiveness of a structured online self-help therapeutic program. Therefore, the present study aims to examine how helpful 'iCanCope' is, an interactive online 6-week self-help coping program, compared to online information only, in improving distress, coping and quality of life after cancer diagnosis.
Novel Dual Domain Targeting Strategies Against ErbB Receptors
Funder
National Health and Medical Research Council
Funding Amount
$711,216.00
Summary
This project will develop innovative strategies to treat cancer through novel antibodies to erbB growth factor receptors, and identify ways to improve conventional treatments.
Design And Delivery Of Peptide-based Anti-cancer Grb7 Inhibitors
Funder
National Health and Medical Research Council
Funding Amount
$603,126.00
Summary
The Grb7 protein is overproduced in many types of cancer cells and plays a role in cancer cell growth and spread. The current proposal builds upon the discovery of a peptide-based Grb7 inhibitor that has anti-cancer activity. This proposal is to prepare more potent inhibitor molecules that can efficiently reach the target cancer cells. Such molecules will be used for the study of Grb7 and for the development of a new Grb7-based anti-cancer drug therapy.
Targeting The Plasmodium Falciparum Metalloaminopeptidases For Development Of New Antimalarial Agents
Funder
National Health and Medical Research Council
Funding Amount
$565,507.00
Summary
Each year 1-2 million people will die from malaria. The prevention and treatment of malaria is becoming increasingly difficult due to the spread of drug-resistance. There is an urgent need for next generation of antimalarials with new modes of action. This project will develop new antimalarial agents against the malarial aminopeptidase drug targets.
Enhancing Cognitive Behavioural Treatment Outcomes For Social Phobia
Funder
National Health and Medical Research Council
Funding Amount
$344,129.00
Summary
Social phobia is a serious difficulty that has a tremendous impact in an individual's life. Psychological programs for social phobia have yielded relatively strong positive outcomes, however some individuals do not gain the optimum benefit from these programs. This study aims to test the effectiveness of an added component in the treatment for social phobia which focuses on increasing engagement with treatment in order to optimise outcomes.
Optimization Of Splice Switching Therapies To Treat Duchenne Muscular Dystrophy
Funder
National Health and Medical Research Council
Funding Amount
$448,827.00
Summary
Duchenne muscular dystrophy, the most common and serious form of childhood muscle wasting, is caused by mutations in the dystrophin gene that block synthesis of the normal product. Antisense oligomers have been used in clinical trials to remove the disease-causing part of the message and rescue expression. Clinical trials have demonstrated proof-of-concept, although individual responses varied. This application seeks to improve the therapeutic potential of these compounds.
A Randomised Open-label Study Comparing The Safety And Efficacy Of Two Alternative Treatment Options In The Management Of HIV-1 Infected Participants Who Have Virologically Failed A Standard First-line Combination ART Regimen
Funder
National Health and Medical Research Council
Funding Amount
$457,676.00
Summary
For the past decade there has been an unprecedented international effort to provide access to care for all HIV-infected people as a basic human right. Most of these people are treated with a simple combination of drugs that are well proven to control HIV. However, what to do when this first drug combination stops working is unknown. This study aims to fill that knowledge gap so that patients failing the first drug combination can be offered a second combination with a maximal chance of success.
Web Based Study Of Risk Factors For Pain Exacerbation In Knee Osteoarthritis
Funder
National Health and Medical Research Council
Funding Amount
$408,501.00
Summary
While much is known about the risk factors for radiographic knee OA, the risk factors for symptoms emanating from joints affected by OA remain unclear. Identifying modifiable methods for alleviating pain and or avoiding risk factors for exacerbations of pain could have tremendous public health importance. In the proposed study we will use the Internet to facilitate data collection to test a set of risk factors for knee pain fluctuation among subjects with symptomatic radiographic knee OA.