Targeting Translational Control By Modulating MiRNA Function As A Novel Way To Treat Respiratory Infections And Inflammatory Disease
Funder
National Health and Medical Research Council
Funding Amount
$700,623.00
Summary
Among the major health issues of today is our inability to effectively treat bacterial infections and the emergence of antibiotic resistant microbes. MicroRNA are small molecules that control the levels of proteins in immune cells that fight infections. In this project we will determine if inhibiting miRNA function in the lung enhances defence against microbial invasion and is a new therapeutic approach to treat infection driven diseases of the airways such asthma and emphysema.
Airway Epithelial Injury And The Innate Lymphoid Cell Response In The Pathogenesis Of Allergic Asthma
Funder
National Health and Medical Research Council
Funding Amount
$607,559.00
Summary
Exposure to airborne particulate pollutants appears to contribute both to the development of childhood asthma and to acute severe attacks of asthma. We will investigate the mechanisms involved, using mouse models of childhood asthma and of asthma exacerbations. In particular, we will focus on the potentially critical role of a newly described population of host defence cells, and how these are activated as a result of injury of the lining cells of the airways.
The Pathogenesis Of Distinct Endophenotypes Of Asthma Is Underpinned By The Collaborative Activation Of Specific PRRs.
Funder
National Health and Medical Research Council
Funding Amount
$678,754.00
Summary
Asthma is a chronic airway disease caused by inflammation. Although asthmatics can be sub-typed based on the type of inflammatory cells present in the lungs, medication specific for the treatment of these sub-types is not yet available. In this grant we will investigate the immune processes that orchestrate the development of the distinct inflammatory sub-types of asthma. This information will help us develop new therapies that will be tailored to target the appropriate type of inflammation.