Inhibition Of Interferon-?/? Induction By Ross River Virus
Funder
National Health and Medical Research Council
Funding Amount
$589,664.00
Summary
Ross River virus is a mosquito-borne virus that causes arthritis in the joints of many people infected. This project will look at the early interactions of a virulent virus with the mammalian host that appear to enable the virus to replicate and spread in the host and thereby cause disease. These interactions are with the host interferon protein which the virus has developed the ability to inhibit. The effect of the invading virus on the host's interferon system, part of the immune system, will ....Ross River virus is a mosquito-borne virus that causes arthritis in the joints of many people infected. This project will look at the early interactions of a virulent virus with the mammalian host that appear to enable the virus to replicate and spread in the host and thereby cause disease. These interactions are with the host interferon protein which the virus has developed the ability to inhibit. The effect of the invading virus on the host's interferon system, part of the immune system, will be examined.Read moreRead less
Discovery Of A Novel Immune Evasion Strategy Employed By Mosquito Borne Viruses To Suppress Antiviral Immune Responses
Funder
National Health and Medical Research Council
Funding Amount
$418,642.00
Summary
The transition from mosquitoes, ticks, or other invertebrate vectors to the human hosts represents a crucial step in the successful establishment of arthropod borne viruses (arboviruses). The incidence of arbovirus infections such as dengue virus, West Nile virus, Ross River virus is increasing at an alarming rate in various parts of the world. In addition, the emergence of new viruses resulting in significant mortality in the population is of utmost concern. Vaccines for many of these viruses r ....The transition from mosquitoes, ticks, or other invertebrate vectors to the human hosts represents a crucial step in the successful establishment of arthropod borne viruses (arboviruses). The incidence of arbovirus infections such as dengue virus, West Nile virus, Ross River virus is increasing at an alarming rate in various parts of the world. In addition, the emergence of new viruses resulting in significant mortality in the population is of utmost concern. Vaccines for many of these viruses remain elusive. One factor that contributes to this is the ability of viruses to develop ingenious strategies to avoid or suppress the host defence systems, which enable its successful establishment in the host. Understanding how viruses evade-suppress host defence machinery will certainly enhance and improve our approaches to fight them. For the first time internationally we have discovered a new and novel pathway employed by arboviruses to suppress antiviral immune responses in the host. We have discovered that naturally occurring carbohydrates on viruses derived from mosquito cells, would influence these virus s ability to evade-suppress host antiviral proteins such as interferons. This may be a general effect of arboviruses or may even extend to other viruses , which include a number of deadly pathogens (HIV, Influenza). This research has the potential to significantly expand our understanding of how these viruses establish infection and cause disease. Also this discovery has broader implications for understanding inflammatory processes and their regulation.Read moreRead less
Space gravity: squeezing the last drop of hydrological information out of current and future missions. Australia needs space gravity measurements in order to estimate regional-scale total water storage changes on our continent. This project will deliver the analysis capability required to exploit all the measurements of the current Gravity Recovery and Climate Experiment (GRACE) mission and to place Australia in a state of readiness for the 2017 GRACE Follow On mission.
Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for ....Applying behavioural insights to the tax system in Australia. Applying behavioural insights to the tax system in Australia. This project aims to improve compliance and payment in the Australian tax system. It aims to tackle debts of individuals and businesses, the most challenging aspect of tax systems, by applying behavioural insights to design innovative payment interventions and conducting rigorous randomised controlled trials to evaluate their effects. An empirical analysis will account for heterogeneity in treatment responses, and the findings will be combined with a study of regulatory and administrative processes to support the ultimate goal of a legitimate, fair, cost-effective and responsive tax system.Read moreRead less
Back to the Future: Interglacial Warming and the West Antarctic Ice Sheet . The Antarctic is highly-sensitive to abrupt changes caused by the passing of tipping points within the climate system. Crucially, the instrumental record is too short to resolve major uncertainties surrounding future warming. The Last Interglacial (125,000 yrs ago) was 2°C warmer than today and experienced 6-11 m higher global sea levels. The role of Antarctica is vital for constraining sea-level projections. This Austra ....Back to the Future: Interglacial Warming and the West Antarctic Ice Sheet . The Antarctic is highly-sensitive to abrupt changes caused by the passing of tipping points within the climate system. Crucially, the instrumental record is too short to resolve major uncertainties surrounding future warming. The Last Interglacial (125,000 yrs ago) was 2°C warmer than today and experienced 6-11 m higher global sea levels. The role of Antarctica is vital for constraining sea-level projections. This Australian-led international project aims to determine the mechanisms and impacts of past interglacial Antarctic warming up to 2°C (relative to pre-industrial). Innovative techniques integrating horizontal ice cores and high resolution marine records will help identify polar tipping points and better plan for impacts in Australia.Read moreRead less
Restorative Justice and Responsive Regulation. The objective of this research is through a series of projects to bring the autor's restorative justice and responsive regulatin research programs of the last decade together, to intergrate them. this means to bear a restorative and responsive approach to transforming the entire legal system, not just criminal or regulatory law/administration. hwever, it does also mean reforming criminological theory with regulatory theory and applying restorative ....Restorative Justice and Responsive Regulation. The objective of this research is through a series of projects to bring the autor's restorative justice and responsive regulatin research programs of the last decade together, to intergrate them. this means to bear a restorative and responsive approach to transforming the entire legal system, not just criminal or regulatory law/administration. hwever, it does also mean reforming criminological theory with regulatory theory and applying restorative justice to business regulation, as well as tort, tax, contract and all areas of law.Read moreRead less
Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data stream ....Risks of rapid ocean warming at the Antarctic continental margin. This project aims to comprehensively understand the interconnected processes by which oceanic heat is circulated towards Antarctica. The risk of rapid ocean warming at the Antarctic margin is profound, with change already detected via deep ocean warming, land-ice melt, and ice shelf collapse. Yet this region remains poorly understood, with only limited observations due to both a harsh environment and a lack of standard data streams. This project will use high-resolution global and regional ocean/sea-ice models to examine mechanisms for rapid warming of Antarctic continental shelf waters via both large-scale drivers and fine-scale processes, including mesoscale eddies, tide-topography interactions, and bottom boundary flows. This work will better constrain future rates of ice melt around Antarctica by providing vital knowledge of the ocean processes, dynamics, and feedbacks relating to warm water intrusion onto the Antarctic continental shelf.Read moreRead less
The Governance of Defiance. Defiance is a threat to social order. For this reason sanctioning institutions are in place to punish the defiant through legal, financial and sometimes physical means. The institutional rationale is that, at worst defiance will be silenced and at best, compliance will take its place. Increasingly, adverse and unexpected consequences of dealing with defiance in this way have been exposed. To be accountable for their actions, therefore, authorities have begun to develo ....The Governance of Defiance. Defiance is a threat to social order. For this reason sanctioning institutions are in place to punish the defiant through legal, financial and sometimes physical means. The institutional rationale is that, at worst defiance will be silenced and at best, compliance will take its place. Increasingly, adverse and unexpected consequences of dealing with defiance in this way have been exposed. To be accountable for their actions, therefore, authorities have begun to develop more responsive and deliberative systems. But they also need to know how to read defiance. When is defiance an inappropriate response to a more than reasonable request? And when is defiance a reflection of institutional failure? This project can inform such decision making.Read moreRead less
GRACE follow-on: validation of measurements and initial results. This project aims to advance knowledge to quantify ongoing mass loss of Earth’s polar ice caps and glaciers, increases in sea level, and changes in continental water storage. The project expects to improve the capability to monitor changes on Earth using satellites and to enhance analysis by exploiting data from new instrumentation on the GRACE Follow-On space gravity mission, due for launch in 2018. Expected results aim to improve ....GRACE follow-on: validation of measurements and initial results. This project aims to advance knowledge to quantify ongoing mass loss of Earth’s polar ice caps and glaciers, increases in sea level, and changes in continental water storage. The project expects to improve the capability to monitor changes on Earth using satellites and to enhance analysis by exploiting data from new instrumentation on the GRACE Follow-On space gravity mission, due for launch in 2018. Expected results aim to improve computational tools and to develop expertise to analyse the new data. Other expected outcomes include reliable methods to monitor significant sea-level rise and associated societal and economic disruptions.Read moreRead less
Interactions of physical processes for Southern Ocean dynamics. The Southern Ocean circulation is a major component of the earth’s climate system. Its behaviour depends strongly on the interactions of physical processes that are poorly understood and are not well represented in ocean models. This project will use laboratory experiments and fully-resolved flow simulations with appropriate scaling to examine the dynamics of key interactions between convection, mixing, wind-driven flow, eddies and ....Interactions of physical processes for Southern Ocean dynamics. The Southern Ocean circulation is a major component of the earth’s climate system. Its behaviour depends strongly on the interactions of physical processes that are poorly understood and are not well represented in ocean models. This project will use laboratory experiments and fully-resolved flow simulations with appropriate scaling to examine the dynamics of key interactions between convection, mixing, wind-driven flow, eddies and large-scale currents, while translating the results to improve ocean models. The project will develop the fundamental physics of the deep overturning circulation, the Antarctic Circumpolar Current, response timescales and heat uptake in a warming world, and improve predictions of oceanic and climate change.Read moreRead less