Computer simulation techniques to reduce the incidence of femoral fracture after hip replacement surgery. Australia's ageing population is driving an increase of 5% to 10% a year in the number of primary total hip replacements. We will move beyond conventional surgical techniques, to deliver the science for an accurate, reliable computer-based system that is significantly more accurate and reliable. Optimising implant selection criteria to better match patients' activity levels and bone physiolo ....Computer simulation techniques to reduce the incidence of femoral fracture after hip replacement surgery. Australia's ageing population is driving an increase of 5% to 10% a year in the number of primary total hip replacements. We will move beyond conventional surgical techniques, to deliver the science for an accurate, reliable computer-based system that is significantly more accurate and reliable. Optimising implant selection criteria to better match patients' activity levels and bone physiology and minimise revision rates; this has major implications for the national health budget and patients' quality of life. Our advances will allow the implementation of improved surgical techniques that minimise the risk of implant related bone failure.Read moreRead less
Discovery Early Career Researcher Award - Grant ID: DE160101098
Funder
Australian Research Council
Funding Amount
$315,000.00
Summary
Novel modelling of fluid-structure interactions in biological flows. The objective of this project is to develop a novel method to model fluid-structure interactions and turbulence in cardiovascular systems. The cardiovascular system is essential in providing nutrient and waste transport throughout the body. Because blood vessels and red blood cells are flexible, they are subjected to large deformations with significant effects on physiological functions such as blood distribution and oxygen rel ....Novel modelling of fluid-structure interactions in biological flows. The objective of this project is to develop a novel method to model fluid-structure interactions and turbulence in cardiovascular systems. The cardiovascular system is essential in providing nutrient and waste transport throughout the body. Because blood vessels and red blood cells are flexible, they are subjected to large deformations with significant effects on physiological functions such as blood distribution and oxygen release. Fluid-structure interactions are critical for understanding the intricacies of such systems but it is still a challenge to model these systems realistically using numerical methods. Expected outcomes of the project include better simulations of three-dimensional fluid-structure interactions and improved understanding of the behaviours of biological systems.Read moreRead less
The development of particle-depleted regions in dense suspensions of neutrally buoyant particles. We aim to measure the spatial variation of fluid speed and particle speed, and of particle concentration, across and along a pipe into which has been introduced a mixture of said particles and fluid. This problem has significance in mechanical and chemical engineering wherever particle/fluid mixtures are flowing. The expected outcomes are recognition of a major contribution to world research, as w ....The development of particle-depleted regions in dense suspensions of neutrally buoyant particles. We aim to measure the spatial variation of fluid speed and particle speed, and of particle concentration, across and along a pipe into which has been introduced a mixture of said particles and fluid. This problem has significance in mechanical and chemical engineering wherever particle/fluid mixtures are flowing. The expected outcomes are recognition of a major contribution to world research, as well as technological applications; one that motivates us is the blood shear in the bearings of a revolutionary Australian blood pump for cardiac assist that avoids both pivots and magnetic suspension for the single moving part.Read moreRead less
Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as rest ....Optimising haemodynamics in complex stented arteries. This project aims to optimise the hemodynamics (blood flow) in coronary arteries with high curvatures and bifurcations. Experience has shown that the build-up of plaque — and the resulting occlusion of blood flow — tends to occur in these complex arterial regions. The most common therapeutic strategy is the insertion of a stent to prop open the artery. However, the nature of the geometry often leads to post-stenting complications such as restenosis and thrombosis, ultimately resulting in negative outcomes. In this project, advanced research methods from fluid dynamics and optimisation and control will be used to potentially minimise these highly undesirable effects.Read moreRead less
Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tiss ....Fundamental theoretical and experimental investigation of cartilage mechanics. Arthritis and chronic joint symptoms are one of the leading causes of disability in the community, yet a fundamental understanding of joint mechanics has yet to be realised. The aim of this project is to develop a new state-of-the-art mathematical model describing cartilage behaviour in humans. The model will explain how activities like walking maintain healthy cartilage by transferring growth factors through the tissue, and quantitatively explain how wear is minimised in cartilage through weeping lubrication. This model will progress our understanding of cartilage mechanics in health and disease, and so help Australians age well and productively.Read moreRead less