Involvement Of Interstitial Cells Of Cajal In The Pathogenesis Of Diabetic Gastroparesis
Funder
National Health and Medical Research Council
Funding Amount
$386,104.00
Summary
Diabetics commonly suffer from gastrointestinal symptoms such as bloating and nausea. We have preliminary evidence that interstitial cells of Cajal (ICC), which are essential for normal gut motility, are particularly vunerable to damage in diabetes. The goal of this study is to determine how the loss of ICC in diabetes leads to delayed gastric emptying. Our overall aim is to identify potential therapeutic targets for improved treatment of diabetes-related gastrointestinal motility disorders.
The Role Of Connexins In Blood Pressure Regulation: Use Of A Conditional Gene Expression System
Funder
National Health and Medical Research Council
Funding Amount
$583,767.00
Summary
Cell coupling through gap junctions is said to play an important role in regulating blood flow and blood pressure. However data obtained from mice, in which specific gap junctions are deleted, may be compromised by compensatory changes in other junctions. We have validated a new method for rapidly and reversibly altering gap junctions in adult mice with oral sugar. This technique will enable us to directly determine whether interference with cell coupling affects blood flow and blood pressure.
Myoendothelial Gap Junctions: Their Composition And Role In Vasodilator Responses Attributed To EDHF
Funder
National Health and Medical Research Council
Funding Amount
$282,750.00
Summary
Cardiovascular disease, including coronary heart disease and stroke, continues to be the major cause of death in Australia and hypertension is a significant risk factor. The endothelium, which lines blood vessels of all sizes, is critical to the control of blood flow to the organs of the body. Endothelial cells release factors which can cause blood vessels to constrict or to relax, thus decreasing or increasing blood flow, respectively. Under normal conditions, the endothelium is more important ....Cardiovascular disease, including coronary heart disease and stroke, continues to be the major cause of death in Australia and hypertension is a significant risk factor. The endothelium, which lines blood vessels of all sizes, is critical to the control of blood flow to the organs of the body. Endothelial cells release factors which can cause blood vessels to constrict or to relax, thus decreasing or increasing blood flow, respectively. Under normal conditions, the endothelium is more important as a source of relaxing factors, while under hypertensive conditions, the balance is shifted in favour of the release of constricting factors. Thus, restoration of the vasodilatory function of the endothelium is seen as an important new therapeutic target in the treatment of vascular disorders. Present data suggests that the action of one of the major endothelial derived vasodilatory factors, the so-called endothelium-derived hyperpolarizing factor, EDHF, requires the presence of particular structures within the vascular wall, but little is known about the molecules of which they are comprised. We have identified two unique situations, during development and during hypertension, when these structures are present in vessels in which they are absent in normal adults. We will use gene microarrays to identify the specific molecules involved in these structures and use physiological studies to test the role of these proteins and structures in vasodilatory responses. The results of these studies may identify new targets for therapeutic intervention to restore the action of EDHF in hypertension.Read moreRead less
Evaluating communication for development: supporting adaptive and accountable development. Australia spends $5.2 billion a year on overseas aid and is increasingly interested in the role of communication in sustainable development. This project will help to create a more effective means of understanding the impact of communication for development and improving its effectiveness in contributing to sustained, positive development outcomes.
Linkage Infrastructure, Equipment And Facilities - Grant ID: LE140100148
Funder
Australian Research Council
Funding Amount
$460,000.00
Summary
TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Au ....TrISMA - Tracking Infrastructure for Social Media Analysis. Tracking infrastructure for social media analysis: The tracking infrastructure for social media analysis (TrISMA) project establishes state-of-the-art technical and organisational infrastructure for the tracking of public communication by Australian users of social media, at large scale, in real time, and for the long term, addressing a significant gap in national research infrastructure. Social media are increasingly embedded in the Australian media ecology, and systematic analyses of how public communication takes place via social media provide rich insights into a range of issues and debates of high importance to our society.Read moreRead less
New Media and Public Communication: Mapping Australian User-Created Content in Online Social Networks. Understanding the ways people contribute to and use the Internet for a wide range of purposes is important to Australia's future from both a social and an economic perspective. Effective, evidence-based policy depends on developing a vastly improved understanding of the current level of Australians' online activities and interests. This project provides crucial, detailed baseline data on the so ....New Media and Public Communication: Mapping Australian User-Created Content in Online Social Networks. Understanding the ways people contribute to and use the Internet for a wide range of purposes is important to Australia's future from both a social and an economic perspective. Effective, evidence-based policy depends on developing a vastly improved understanding of the current level of Australians' online activities and interests. This project provides crucial, detailed baseline data on the social, cultural and technological dynamics of Australian online public communication, which can inform further government initiatives to strengthen the country's digital economy and to maximise civic engagement through media participation.Read moreRead less
Soft Infrastructure, New Media and Creative Clusters: Developing Capacity in China and Australia. The project will position Australia at the forefront of the creative industries internationally and enhance national capacities in the rejuvenation and design of creative urban precincts. A greater appreciation of, and strong links with China, particularly its design and urban sectors, will result. Australian firms will benefit through greater trade opportunities as a result.
A hand up: Disrupting the communication of intergenerational welfare dependency. Some families rely permanently on welfare support and communicate this dependency to the next generation. Children growing up in these families find it difficult to break out of poverty. With the help of twelve families and members of the St Vincent de Paul Society (Western Australia), this project aims to create ethnographies which illuminate turning points and opportunities for change. It will look to use creative ....A hand up: Disrupting the communication of intergenerational welfare dependency. Some families rely permanently on welfare support and communicate this dependency to the next generation. Children growing up in these families find it difficult to break out of poverty. With the help of twelve families and members of the St Vincent de Paul Society (Western Australia), this project aims to create ethnographies which illuminate turning points and opportunities for change. It will look to use creative and educational interventions to explore new ways of delivering services and disrupting the communication of welfare dependency. Ending inherited poverty is a significant step in helping individuals reach their potential and frees resources for people facing sudden hardship.Read moreRead less
The uses of romance for new demographics and multimedia platforms: A model of media innovation in international women's fiction publishing. The national benefit of this project is both economic and socio-cultural. Economically, it investigates new ways to produce and distribute Australian creative content for local and export markets. It identifies how branch offices of global firms can be creative offices. Culturally, it develops scenarios for maximizing the acceptance, uptake and use of digita ....The uses of romance for new demographics and multimedia platforms: A model of media innovation in international women's fiction publishing. The national benefit of this project is both economic and socio-cultural. Economically, it investigates new ways to produce and distribute Australian creative content for local and export markets. It identifies how branch offices of global firms can be creative offices. Culturally, it develops scenarios for maximizing the acceptance, uptake and use of digital technologies by both large-scale publishers and young Australians. It investigates agents along the length of the creative value chain - from authors to audiences - to determine the uses of creative fiction, identifying the features that attract / repel users of published fiction in these genres. Finally it extends the capabilities of users to create their own romance content.Read moreRead less