Molecular Genetic Analysis Of BRCT Domain Function And RhoGEF Signalling In DNA-damage Response And Apoptosis.
Funder
National Health and Medical Research Council
Funding Amount
$195,691.00
Summary
Cancers arise as a consequence of a series of genetic changes, usually by mutation of DNA. DNA is consistently exposed to an array of damaging agents, but the majority of mutations are corrected by cellular repair mechanisms. We now know that if these mechanisms work normally, too few mutations persist for cancer to result. However if these DNA damage repair mechanisms are themselves faulty, a high mutation rate occurs and a high risk of cancer results. DNA damage has another outcome. If the dam ....Cancers arise as a consequence of a series of genetic changes, usually by mutation of DNA. DNA is consistently exposed to an array of damaging agents, but the majority of mutations are corrected by cellular repair mechanisms. We now know that if these mechanisms work normally, too few mutations persist for cancer to result. However if these DNA damage repair mechanisms are themselves faulty, a high mutation rate occurs and a high risk of cancer results. DNA damage has another outcome. If the damage is too extensive, the cell commits suicide, not because it cannot function, but because it senses the DNA damage and chooses to die. One poorly understood aspect of the response to DNA damage is how the cell senses the damage and activates the suicide process. We have discovered a novel gene that appears to play a role in this sensing and suicide signalling process. The mouse version of this gene can itself act as a cancer-causing gene. We propose, however, to study the equivalent gene in Drosophila melanogaster, a more powerful experimental system, to characterise in detail its role in these processes. In this way we hope to generate a much more detailed understanding of the way that cells deal with DNA damage and choose suicide when the damage is too severe.Read moreRead less
Worldwide: the history of the commercial arm of the British Broadcasting Corporation (BBC). This project will result in a greater historical understanding of how state funded public service broadcasters develop and manage their commercial operations. The BBC's commercial arm was emulated by public service broadcasters across the world, not least by the Australian Broadcasting Corporation which was also a key client and partner. This history will enhance our understanding of public service broadc ....Worldwide: the history of the commercial arm of the British Broadcasting Corporation (BBC). This project will result in a greater historical understanding of how state funded public service broadcasters develop and manage their commercial operations. The BBC's commercial arm was emulated by public service broadcasters across the world, not least by the Australian Broadcasting Corporation which was also a key client and partner. This history will enhance our understanding of public service broadcasting by examining the industrial and cultural innovations that are needed if the delivery of public content in Australia is to survive in a highly privatised digital environment.Read moreRead less
Media transformation in its Australian and international contexts: analysis and theory-building. This project provides a new perspective on historical and contemporary media by exploring the multifaceted character of Australian media transformation since the introduction of television. It examines the changing relations among media and the roles played by particular cities and their screen production facilities, infrastructures and creative processes.
Discovery Early Career Researcher Award - Grant ID: DE140101412
Funder
Australian Research Council
Funding Amount
$383,532.00
Summary
The New Politics of Food and the Australian Media. The provenance of food and the ethics of food production and consumption are increasingly a focus of mainstream media, including television cooking shows, cookbooks, advertising, news and online media. This is the result of alliances between the media and the food industries, alliances that are reinvesting food and food politics with new meaning and significance. This project investigates the complex dynamics of interaction between these two imp ....The New Politics of Food and the Australian Media. The provenance of food and the ethics of food production and consumption are increasingly a focus of mainstream media, including television cooking shows, cookbooks, advertising, news and online media. This is the result of alliances between the media and the food industries, alliances that are reinvesting food and food politics with new meaning and significance. This project investigates the complex dynamics of interaction between these two important Australian industries by examining their texts, economies and practices. It will reveal their significant effects on corporate decision-making, consumer behaviours, public debate and national policy.Read moreRead less
Early Television Drama in Australia, Great Britain and the USA. This project will reevaluate the history of early television drama by adopting a comparative perspective that examines Australian, UK and US drama during the period 1956-1964. Television drama was both a primary site where emerging national television systems could explore and showcase the potentialities of the new medium and a site in which there was considerable international sharing of critical understandings, production practice ....Early Television Drama in Australia, Great Britain and the USA. This project will reevaluate the history of early television drama by adopting a comparative perspective that examines Australian, UK and US drama during the period 1956-1964. Television drama was both a primary site where emerging national television systems could explore and showcase the potentialities of the new medium and a site in which there was considerable international sharing of critical understandings, production practices and creative ambitions. This project will map an international television ecology by evaluating these three national television drama systems and tracing the systems of interchange among them.Read moreRead less
Film as Philosophy: Understanding Cinematic Thinking. The project benefits Australia by initiating collaboration between the disciplines of film and philosophy, establishing a network of scholars of international renown and a forum for their interaction to steer the future development of a significant field of contemporary interdisciplinary investigation. It will augment Australia's international standing in continental philosophy and serve the community by opening up a new research area that st ....Film as Philosophy: Understanding Cinematic Thinking. The project benefits Australia by initiating collaboration between the disciplines of film and philosophy, establishing a network of scholars of international renown and a forum for their interaction to steer the future development of a significant field of contemporary interdisciplinary investigation. It will augment Australia's international standing in continental philosophy and serve the community by opening up a new research area that stands to integrate film studies within the core of humanities education in tertiary institutions. This will ensure the ongoing relevance of philosophical and aesthetic research to contemporary cultural formations and stimulate ethical debates about culture and the mass media in the broader community.Read moreRead less
Entertainment rights in the age of the franchise: a reappraisal of personality rights under Australian intellectual property laws. Global entertainment industry practice is to assert broad rights in creative entertainment concepts and characters. There is huge global merchandising potential for cultural products, as demonstrated by The Wiggles, Harry Potter and Pokemon. In the US, the UK, Japan and Korea there have been developments to enhance the protection of character and personality rights. ....Entertainment rights in the age of the franchise: a reappraisal of personality rights under Australian intellectual property laws. Global entertainment industry practice is to assert broad rights in creative entertainment concepts and characters. There is huge global merchandising potential for cultural products, as demonstrated by The Wiggles, Harry Potter and Pokemon. In the US, the UK, Japan and Korea there have been developments to enhance the protection of character and personality rights. However there is no current study of the status of the entertainment franchise under Australian intellectual property law. With Australian imports of cultural products at an all-time high and with local productions increasingly geared towards worldwide audiences, this study critically evaluates how Australian law fits with the realities of the global entertainment marketplace.Read moreRead less
Dynamic media: innovative social and artistic developments in new media in Australia, Britain, Canada and Scandinavia since 1990. This study will foreground strengths and remedy weaknesses in Australian new media arts and innovative social uses of new media. By studying the international strategies for social use of dynamic media, this study will provide information for Australians to more extensively implement dynamic media within a social context. It will highlight the innovation of Australian ....Dynamic media: innovative social and artistic developments in new media in Australia, Britain, Canada and Scandinavia since 1990. This study will foreground strengths and remedy weaknesses in Australian new media arts and innovative social uses of new media. By studying the international strategies for social use of dynamic media, this study will provide information for Australians to more extensively implement dynamic media within a social context. It will highlight the innovation of Australian artists and researchers in the development of dynamic media and position these internationally. A major long-term benefit of this study will be an online database that will both profile and be accessible to Australian artists, arts organizations, new media researchers and social innovators. Read moreRead less